@LabScorrano

Scorrano Lab @DiBio_UniPD & @VIMMPadua. We study #mitochondria #celldeath #contactsites #metabolism #cristae #Opa1. Luca's tweets are signed LS

 Padua, Italy
vimm.it/scientific-board/luca-scorrano/
Joined September 2018
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This is your reminder there is only ✨2 WEEKS✨to go until our final registration deadline for #FusionAging25 📜Final Few Poster Slots Remaining! 🗓️Deadline: Thursday 07 Aug 2025 🔗Register here: bit.ly/4lL9Y64
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Kudos to Antigoni Diokmetzidou, @aurora_maracani, @mau_carr, @AnnaPellattiero, Erwan Rivière for their new @cddpress paper where we make good use of the Opa1 inhibitors that we generated in the lab! Check the paper out here rdcu.be/ew6LX 1/6
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Pharmacological inhibition with our OPA1 inhibitors MYLS22 and Opitor‑0 confirms selective vulnerability: these small molecules reduce migration and induce cell death exclusively in metastatic lines. 5/6
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This work identifies OPA1-targeting strategies as promising for metastatic TNBC. Big thanks to the funders @AIRC_it @Fondaz_Veronesi 6/6 LS
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I promise that the style of our presentations is a little bit more plain. LS
Mambo Italiano
@mamboitaliano__8 Jul 2025
If you’re visiting Puglia, Italy 🇮🇹 this summer, don’t forget to stop by Scorrano A small town in the province of Lecce, known worldwide for its stunning light displays ✨ These are true Gothic cathedrals made of lights and colors The very essence of Southern Italy
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This poster is a must have for labs working on #MCS! A guide through the work of so many outstanding labs (apologies if we did not cite your work). Hang it in your office or lab, it will please your eyes and inspire your mind! Kudos to the driving force Antigoni Diokmetzidou! -LS
J Cell Science@J_Cell_Sci19 May 2025
In their Cell Science at a Glance article, Antigoni Diokmetzidou & Luca Scorrano @LabScorrano summarise the mitochondrial contacts characterised in mammals, the mechanisms underlying their formation, and their principal functions. journals.biologists.com/jcs/… #JCSMitoSI #OpenAccess
JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano

ALT JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano

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Kudos to @AnnaPellattiero C Quirin @MagrinFederico, great collaborators S Moro A Mattarei @msturlese @ProfGavathiotis for our latest @ScienceAdvances paper science.org/doi/10.1126/scia…. Many years in the making but finally we have OPA1 inhibitors reverting cancer chemoresistance! 1/

Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to...

OPA1 inhibitors from large-scale screening and chemical optimization restore cancer cell sensitivity to apoptosis-inducing drugs.

science.org
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10/ Stay tuned for our collaborative work with the labs of @glytsou @iannisaifantis1 where we show how effective these new Opitors are in models of #AML, where #Venetoclax resistance can be driven by OPA1 and is an important and unmet clinical need!
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11/11 Special thanks to @AIRC_it that funded this project @FRBiomedica since its inception and to grants from @FondazioneHeal @fondcariparo @mur_gov_. Many improved Opitors to follow, hoping to bring them soon to the clinics for the benefit of #AML and other cancer patients! LS
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