Looking for a comprehensive review on the neuronal endoplasmic reticulum? Look no further! Our review just got published in Nature Reviews Neuroscience!
nature.com/articles/s41583-0…
Huge thanks to my co-authors @liacarvalhais and @marijn_kuijpers !
Check out our new preprint! We combine EM data, genetically encoded tools and single-cell electrophysiology to investigate mitochondria at the AIS, where they cluster and strongly buffer Ca2+. Surprising: they don't impact electrophysiological properties.
biorxiv.org/content/10.1101/…
Koen Kole retweeted
I am hiring soon (PhD and post-doc) and will be at #SfN23 in November! Ping me to grab a drink and talk about the AIS, our lab, living in The Netherlands, being a parent in academia or anything related to food/wine/cheese!
Koen Kole retweeted
Myelin is widely believed to protect axons from damage in multiple sclerosis. A study in @NatureNeuro challenges this view and finds that myelin insulation renders axons more vulnerable to degeneration in an autoimmune environment. go.nature.com/44sSkee
Koen Kole retweeted
From pre-clinical studies to clinical research and from single axon recordings to human MRI studies. It promises to be an enlightening and thought-provoking session that you won't want to miss! See you on Monday!
#glia2023 @ConstanzeDepp @MichaelEwers12
Koen Kole retweeted
Vacancy Alert💼Technical assistant electron microscopy. To better understand and improve myelin recovery, we aim to visualize the onset of myelin recovery at the ultrastructural level. You are responsible for the preparatory work an EM execution. nin.nl/vacancies/technical-a…
Koen Kole retweeted
💥Preprint!💥 I am excited to show you our work “The therapeutic mechanism of deep-brain stimulation”! @_the_ing and I have worked on this for over 4 years. Big thanks to our co-authors @AlfredoElhz, @EnnyvBeest, @aishu1803, Peter, and Damiaan Denys (1/14) biorxiv.org/content/10.1101/…
Koen Kole retweeted
Researchers at the Netherlands Institute for Neuroscience have discovered that the energy management of inhibitory brain cells is different compared to excitatory cells in our brain. Why is that the case and what is the link with multiple sclerosis?
nin.nl/nieuws/myelin-determi…
Koen Kole retweeted
Kuijperslab/ group "Molecular Mechanisms of Neurodegeneration" is taking shape🥳. We are still looking for a Postdoc. If interested send a message or email to [email protected]
ru.nl/donders/research/theme…
Koen Kole retweeted
Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes ift.tt/8nfreY9
It is out! We found myelin-dependent clustering of mitochondria in parvalbumin interneurons but not L2/3 pyramidal neurons. Myelin sheaths also effectively attenuate mitochondrial calcium responses. Read all about it in the open access paper linked below! nature.com/articles/s41467-0…
Koen Kole retweeted
We are hiring!
PhD position for a neuroscience project at Donders Institute for Brain, Cognition and Behaviour and Radboud University Medical Centre, The Netherlands.
fens.org/careers/job-market/…
ru.nl/en/working-at/job-oppo…
Koen Kole retweeted
fens.org/careers/job-market/…
We are looking for a PhD candidate at Donders Institute to investigate signal processing on dendrites of human and non-human primate cultured neural networks derived by iPSC technique, addressing the evolutional aspect of neural computations.
Koen Kole retweeted
We are looking for a PhD candidate for an exciting new project at Radboud University. We will run neurophysiological investigation of signal proessing on dendrites of human and non-human primate cultured neural network derived by iPSC technique.
ru.nl/en/working-at/job-oppo…
Koen Kole retweeted
Also come check out our exciting collaboration with @paolo_papale and @LarsMuckli, we compared responses to visual feedforward and contextual stimuli across species. S03-481, Monday morning! #FENS2022
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Koen Kole retweeted
If you're at #FENS, come visit my poster! I'll be presenting the zeta-test for neuronal responsiveness with its newest addition: it now also works for time-series data, like calcium imaging. Still better than t-tests and ANOVAs!
11-07-2022, 09:30 - 13:00
Poster S03-480
New paper out in eLife!🎉
It describes a new binning-less & parameter-free statistical test for neuronal responsiveness. No more binning, regularizing or parameter tuning! Now you can use the ZETA-test: simpler than a t-test, and better than an ANOVA! 1/
elifesciences.org/articles/7…
Koen Kole retweeted
I'm presenting at #FENS2022! If you're interested in chandelier cells, come find me at poster S04-564. We studied connectivity and physiology of chandelier cells in mouse visual cortex. Hope to see you there!
How does myelination of PV interneurons affect the mitochondria of these fast-spiking cells? Turns out it clusters mitochondria and controls their calcium buffering! Check out our new preprint: biorxiv.org/content/10.1101/…
