The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research
University of Dundee
Joined May 2019
- Tweets100
- Following139
- Followers146
- Likes393
Moraga Lab retweeted
After a hard year, I’m glad to see this finally over the line. A real team effort from @YiboJin @scott_d_gardner @TomasVoisin and others from @LabMoraga. As always, amazing data collection support @eBIC_Diamond #cryoem nature.com/articles/s41467-0…
Moraga Lab retweeted
Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains
nature.com/articles/s41467-0…
Moraga Lab retweeted
🚨2 Yr Postdoc Available🚨
Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed @CBR_UoY @YBRI_UoY
Apply here 👇👇👇jobs.york.ac.uk/vacancy/post…
Pls retweet and DM!
Moraga Lab retweeted
Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis biorxiv.org/cgi/content/shor… #bioRxiv
Moraga Lab retweeted
📜State-of-the-Art📜
Molecular and cellular factors determining the functional pleiotropy of cytokines
🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from @dundeeuni
🔗 buff.ly/3pWOAme
#cytokinesignalling #endosomessignalling
Moraga Lab retweeted
So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies.
Not a session to miss!
10:15 AM-12:15 PM room 102AB
Attending @ImmunologyAAI this week and love cytokines? @CytokineSociety: Modulating Cytokine Activity through Structural Knowledge – Saturday; 10:15 AM – 12:15 PM; Room 102AB. Organized by @DrJuanLMendoza with lots of cool cytokine engineering @SpanglerLab @Regeneron
Moraga Lab retweeted
Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in @NatRevImmunol — great team work together with @Lab_Jenkins, Stefan Rose-John @kieluni and Jens Moll/Jürgen Scheller @HHU_de
Moraga Lab retweeted
Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
cytokinesociety.org/understa… via @httpstwittercomCytokineSociety
Moraga Lab retweeted
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
cytokinesociety.org/understa… via @httpstwittercomCytokineSociety
Moraga Lab retweeted
NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block.
🔗➡️bit.ly/Cancer_Immuno
Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!
Moraga Lab retweeted
#Cancer
L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie.
➡️bit.ly/3hLyjNq
Moraga Lab retweeted
SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm @at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 ow.ly/QAse50M3ptF
Moraga Lab retweeted
Today's #shoutout to #womeninSTEM goes to SILVIA GAGGERO for her @SciImmunology paper w/ @at_Mitralab showing IL-2 is inactivated by the acidic pH environment of #tumors enabling engineering of a pH-selective mutein.
science.org/doi/10.1126/scii…
Moraga Lab retweeted
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments.
Read more in @SciImmunology: scim.ag/R5
Moraga Lab retweeted
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments.
Read more in @SciImmunology: scim.ag/O8
Moraga Lab retweeted
Another straightforward reason why the Warburg metabolism causes immune suppression in the TME
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein science.org/doi/10.1126/scii…
Moraga Lab retweeted
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments.
Read more: scim.ag/ME @roychoudhurilab @LabMoraga @at_Mitralab @Inserm @Canther_Lille @CamPathology
Moraga Lab retweeted
Very interesting paper by my former colleague Suman Mitra @at_Mitralab describing an engineered IL-2 molecule w maintained activity in acidic tumor environments.
An IL-2 variant overcame challenges experienced in low-pH environment of tumors to promote CD8 T cell and NK cell functions in mouse models of melanoma. @roychoudhurilab @LabMoraga @at_Mitralab @Inserm @Canther_Lille @CamPathology
📄: scim.ag/KD
Moraga Lab retweeted
Our understanding of pH selectivity in immune responses continues to improve. Here is some fascinating work on inherent and engineered IL-2 pH selectivity from @at_Mitralab and colleagues. science.org/doi/10.1126/scii…