@BubeckLab

Our lab adopts a structural biology approach to investigating the role of membrane proteins in host-pathogen interactions.

 Imperial College London, UK
profiles.imperial.ac.uk/d.bubeck
Joined October 2015
  • Tweets836
  • Following495
  • Followers1.3K
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We're recruiting! Looking for a postdoc in a fun and inclusive lab doing cutting edge #CryoEM in a great city? Come join us @imperialcollege and be part of an interdisciplinary team funded by @wellcometrust @ImperialLifeSci imperial.ac.uk/jobs/search-j…
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Am getting tired of seeing trump news in my feed. Which platform have #cryoEM people migrated to?
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Exciting cryoET structure of the COPII coat from the Zanetti lab. rdcu.be/dZuzf
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Congratulations to Prof Paul Birch, based @JamesHuttonInst and Head of the Division of Plant Sciences @dundeeuni, who was recently awarded the @BS_PP RKS Wood Prize 🏆 The prize celebrates excellent #science in the study of #plantdisease biology. More: bit.ly/48DuShV
British Society for Plant Pathology@BS_PP
14 Oct 2024
Exciting news! 🎉 BSPP's 2025 RKS Wood Prize has been awarded to Professor Paul Birch for his outstanding contributions to plant pathology. 🌿🔬 Learn more about his incredible achievements and this prestigious award here:📷buff.ly/4h95btp
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📢Are you interested in cryo-EM, AI and Machine Learning? Then please check out the open #PhDposition in @Specklab and Yuriy Chaban’s group - Developing AI Approaches to Uncover Regulatory Protein Dynamics in DNA Replication at the MRC LMS on FindAPhD.com
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October is #BreastCancerAwareness month. Early detection is so important. To all my @PinkSisters__ you got this!
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We spoke to Professor Simon Newstead (@inwardopen) from the @UniofOxford about how his research could lead to new medications to treat pain with reduced side effects. Find out more ⤵️ linkedin.com/pulse/treatment…

Treatments for pain can be addictive – but this research could change that

This month's guest expert is Professor Simon Newstead, David Phillips Chair of Molecular Biophysics at the Department of Biochemistry, University of Oxford. Pain is the largest contributor to...

linkedin.com
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Final version of our manuscript reporting how a plant pathogen hacks host membrane trafficking is out. Great team work with @dromius @BubeckLab and @KamounLab science.org/doi/10.1126/scia… 😊👇

A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert...

A pathogen hijacks a plant protein to avoid immune defenses by reprogramming host intracellular trafficking.

science.org
Enoch Lok Him Yuen@EnochYuen
15 Jan 2024
Mind the GAP-New research alert!🚨Our latest study revealed the first known case of a pathogen effector targeting a RabGAP! 🦠The effector remodels the pathogen interface and suppresses defense-related secretion mediated by its cognate Rab.🌱🚦 #research biorxiv.org/content/10.1101/…
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Amazing work from Bubeck lab alumnus @sernarina 👏
Llorca lab@LlorcaLab
25 Sep 2024
The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona. authors.elsevier.com/c/1jpyq…
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Our new preprint, in collaboration with @KamounLab and contributions from @jonathandgjones, @AdamWu9527, and @JiorgosKourelis labs, on the exciting discovery of organelle targeting by an activated helper NLR is out! 👇
Tarhan Ibrahim@TarhanEI
23 Sep 2024
🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.09.19.6…
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I have an exciting postdoctoral position @imperialeee on machine learning for Computational Light-field Microscopy. More details here: jobs.ac.uk/job/DJV050/resear…
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Meeting alert - Biological Structures Group Winter meeting 2024 will be hosted by @Carter_Lab at the MRC LMB on December 6th! We have a fantastic line up of speakers and opportunities for poster presentations. @BiochemOxford @KavliOxford
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Congratulations to @DylanNoone3 a new postdoc in the lab on publishing some of his PhD research!
This Post is from an account that no longer exists. Learn more
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Postdoctoral position UK #postdoc #postdoctoral #AcademicTwitter
Bubeck Lab@BubeckLab
10 Sep 2024
We're recruiting! Looking for a postdoc in a fun and inclusive lab doing cutting edge #CryoEM in a great city? Come join us @imperialcollege and be part of an interdisciplinary team funded by @wellcometrust @ImperialLifeSci imperial.ac.uk/jobs/search-j…
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Replying to @BubeckLab @imperialcollege @wellcometrust @ImperialLifeSci
The big one is the complement membrane attack complex (MAC), which can kill bacteria and damage human cells. The little one is CD59, your last line of defence against MAC! doi.org/10.1038/s41467-023-3… @NatureComms @ERC_Research

Structural basis for membrane attack complex inhibition by CD59

Nature Communications - CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins. As...

nature.com
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Next, @TarhanEI will discuss 'AI-guided structural approaches in deciphering viral modulation of plant autophagy' 🪴
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Congratulations to former postdoc in the lab Marina @sernarina!
CNIO Stop Cancer@CNIOStopCancer
9 Sep 2024
#CNIOStopCancer researcher from @LlorcaLab Marina Serna, awarded for her contribution to solving a crucial biological problem.🔬 cnio.es/en/news/cnio-researc…

CNIO researcher Marina Serna, awarded for her contribution to solving a crucial biological problem

Proteins are the molecules responsible for cells, and therefore the whole organism, to work. They perform a myriad of different tasks, and they do so by ‘fitting’ into each other, like pieces of a...

cnio.es
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Great story! We just did it for #journalclub
RadfordLab@RadfordLab
2 Sep 2024
New paper from our team using smFRET MS and cryoEM to see SurA delivering OMPs to BAM. Well done all - proud to work with you all! rdcu.be/dSDfs.
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Bubeck Lab retweeted
RadfordLab@RadfordLab
2 Sep 2024
New paper from our team using smFRET MS and cryoEM to see SurA delivering OMPs to BAM. Well done all - proud to work with you all! rdcu.be/dSDfs.
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Congratulations to group leader Giulia Zanetti, currently on secondment at the Crick from @ucl and @BirkbeckUoL, on being awarded £1.2m from @The_MRC 🥳 The funding will support her lab's research into complex secretory processes in animal cells crick.ac.uk/news-and-reports…

MRC funding secured to visualise how cells deliver proteins to the correct location

Giulia Zanetti, Head of the Membrane Architecture Laboratory at the Crick, UCL and Birkbeck College, has been awarded £1.2m from the Medical Research Council (MRC) to use advanced microscopy techni...

crick.ac.uk
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