@LabGlover

We study the regulation of cell division, focusing on centrioles, centrosomes and MTOCs. Lab news from @Caltech

 Pasadena, USA
gloverlab.com
Joined August 2017
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📢** New Paper Alert** "Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation" doi.org/10.1098/rsob.240325

Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation

Abstract. The conserved process of centriole duplication requires the establishment of a Sas6-centred cartwheel initiated by Plk4’s phosphorylation of Ana1

royalsocietypublishing.org
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Our research in the fly, suggests that the Ana1 adopts different structures for each of these processes. We show this by generating different variant proteins that could restore centriole duplication to ana1 mutants, but not centriole elongation required to make flagellae. [2/3]
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This predicts that the counterpart protein functions the same way in human cells and may have relevance to human cancer, where centriole duplication goes out of control. [3/3]
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We are very sad to hear of the passing of Adelaide Carpenter, who had been in Genetics at Cambridge for over 30 years working mainly in our lab. A former full professor at UCSD, Adelaide came to Cambridge on sabbatical and never returned.  Continued below... – at Pasadena, CA
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Adelaide will be greatly missed. - David M Glover – at Pasadena, CA
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Adelaide was a world expert in Drosophila meiosis and the best fly geneticist in the Department. She left a technician’s position in the Ashburner lab to join us as research associate and made pioneering contributions to our genetic studies of Greatwall kinase and its substrates – at Pasadena, CA
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📢 ** New Paper Alert** We show that centriole 9-fold microtubule symmetry is not essential for centriole elongation, correct distribution of the centriole’s components along its length, and in initiating aspects of centriole duplication. @NatureComms nature.com/articles/s41467-0… – at Pasadena, CA
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I have a new parthenogenesis paper with @LabGlover! We found that aneuploidy arises during development in natural Drosophila parthenogens and our genetically induced parthenogens @HeredityJournal doi.org/10.1038/s41437-023-0…
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Just got a sneak peek at the group photo from #Centrosomes2023 in Taksim Square! 240 brilliant scientists from around the globe came together, enriching the İstanbul’s scientific bonds and outreach! – at İstanbul, Türkiye
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Pallavi Panda broke my heart @centrosomes2023 by showing that centrioles work just fine even without their beautiful nine-fold symmetry. duplication. MT organisation. No pb. of course we all want to know what happens to cilia ... !
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**New Paper**
Alexis L Sperling@AlexisLSperling29 Jul 2023
I am excited to share the final version of our work on the genetic basis of virgin birth (parthenogenesis) in fruit flies! It was a joy working with @DK_Fabian @erikgarrison @LabGlover on this understudied phenomenon. cell.com/current-biology/ful…

A genetic basis for facultative parthenogenesis in Drosophila

Sperling et al. demonstrate that facultative parthenogenesis can be engineered in the non-parthenogenetic D. melanogaster by manipulating candidate genes identified in the naturally parthenogenetic...

cell.com
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Prepare to be amazed: some parthenogenetic flies reproduce as larvae and the offspring burst forth from their mother in a sci-fi-worthy spectacle! 🪰👽 That and other fly facts in our review @labglover #Parthenogenesis #AlienInspired #Entomology
Royal Society Publishing
@RSocPublishing23 Mar 2023
New Review in #ProcB - Parthenogenesis in #dipterans: a genetic perspective #OpenAccess royalsocietypublishing.org/d… #Genomics #Evolution @AlexisLSperling @LabGlover
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It was nice meeting everyone at the #CSHAsia #Cilia & #Centrosomes Meeting. We hope everyone had a good time with us and have a safe trip home! #Cell #Cilium #Centriole #Microtubules #Mitosis #CellDivision #Cellpolarity #CellMotility #Ciliopathies #ciliogenesis #CSHAsiaCilia2023
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Centrosome tweeps, "Centrosomes in Development, Disease and Evolution" hybrid meeting will be in Istanbul on 26-29 September, 2023. We secured funding from @EMBO @Co_Biologists, registration will start soon. Join us for the largest international #centrosome meeting. Please RT! – at İstanbul, Türkiye
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Thanksgiving with the hearts of two labs, sharing happiness of this year
Thanksgiving with the hearts of two lab, sharing

ALT Thanksgiving with the hearts of two lab, sharing

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Happy #FluorescenceFriday! This is a captivating image from @Levente87 @LabGlover @Caltech. Their work discusses the evolutionary conservation of Gorab (trans-Golgi) and the divergence of binding partner Sas6 (inner core procentriole). 📖 @BiologyOpen: doi.org/10.1242/bio.059545
Drosophila S2 cells transiently transfected with Myc-tagged human SAS6 and GFP-tagged human GORAB. Scale bar 5 μm.

ALT Drosophila S2 cells transiently transfected with Myc-tagged human SAS6 and GFP-tagged human GORAB. Scale bar 5 μm.

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Farewell to our fabulous summer students, Hanna & Buraq! Happy that they had an enriching Summer in the lab exploring centrosomes/cilia, as much as we enjoyed their curious, youthful spirit! – at Pasadena, CA
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Such beautiful clarity of the microtubule triplets and 9-fold symmetry 😍 – at Pasadena, CA
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