@LabCollinson

Exploring protein transport across and into biological membranes, focusing on bacteria and mitochondria 🦠🔬 @BristolBiochem 🧬🧫 Tweets from lab members

 University of Bristol
collinsonlab.squarespace.com
Joined November 2018
  • Tweets127
  • Following212
  • Followers404
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Collinson Lab retweeted
adam grieve@adam_grieve16 Nov 2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Collinson Lab retweeted
Jon Lane 𓅪@Jon_D_Lane14 Nov 2024
Interested in iPSCs, astrocytes, and neuroinflammation? Looking for a PhD? Then you might be interested in this! We have a PhD project available with @LACrompton80 on the @SWBio_DTP programme. You can find details here: findaphd.com/phds/program/ph…

FindAPhD : PhD studentships with the South West Biosciences Doctoral Training Partnership (SWBio...

Apply for a PhD: PhD studentships with the South West Biosciences Doctoral Training Partnership (SWBio DTP) at University of Bristol

findaphd.com
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Collinson Lab retweeted
Luca Troman@luca_troman5 Mar 2023
A bit late to the game my PhD work was published last week with work from the legendary @LabCollinson (with @IanofBristol & @alvipur), @the_gold_lab and @DaumLaboratory in @Biochem_Journal and my artwork made the cover! Check it out! portlandpress.com/biochemj/a…
Feb2023 BiochemicalJournal cover depicting the bacterial secretion machinery (within the lipid membrane, grey), showing the recruitment of chaperone SurA (orange) to help protein substrate (black) translocate through the protein-channel (magenta) via association with ancillary translocation components SecDF-YidC (green and yellow). Translocation of the peptide through the channel is aided by ATP hydrolysis by SecA ATPase (translucent red) and potentially movement of protons (H+) through a proton-wire in SecDF (green) down an electrostatic and concentration gradient.

ALT Feb2023 BiochemicalJournal cover depicting the bacterial secretion machinery (within the lipid membrane, grey), showing the recruitment of chaperone SurA (orange) to help protein substrate (black) translocate through the protein-channel (magenta) via association with ancillary translocation components SecDF-YidC (green and yellow). Translocation of the peptide through the channel is aided by ATP hydrolysis by SecA ATPase (translucent red) and potentially movement of protons (H+) through a proton-wire in SecDF (green) down an electrostatic and concentration gradient.

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Collinson Lab retweeted
Ian Collinson@IanofBristol2 Feb 2022
Will's (@Murmeth @LabCollinson @BristolBiochem) new paper with @DanielWWatkins @RobinCorey1 @sofiaol43489629 and @cooklabuoonz, Kiel Hards (@otago). His magnum opus, literally years in the making towards a mechanism for ATP and PMF-driven protein secretion biorxiv.org/content/10.1101/…

Rate-limiting transport of positive charges through the Sec-machinery is integral to the mechanism...

Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery. In bacteria, this is usually achieved when...

biorxiv.org
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Replying to @DanielWWatkins
@DanielWWatkins' (@BristolBiochem @LabCollinson) new paper is out! A potpourri of interactions around the bacterial Sec translocon - now for submission *. Thanks to our funders @BBSRC biorxiv.org/content/10.1101/…

A bacterial secretosome for regulated envelope biogenesis and quality control

As the first line of defence against antibiotics, the Gram-negative bacterial envelope and its biogenesis are of considerable interest to the microbiological and biomedical communities. All bacterial...

biorxiv.org
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SWBio PhD project (partly in @LabCollinson) involving CRISPR (cool), mitos (cool) and protein transport assays (VERY cool)
Jon Lane 𓅪@Jon_D_Lane15 Oct 2021
We are recruiting PhD students!! Project (1): CRISPR-based mitophagy screens for regulators of mitochondrial protein import quality control (with @IanofBristol) cpb-eu-w2.wpmucdn.com/blogs.… Email or DM me! @SWBio_DTP #Autophagy #Mitophagy
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Our first steps towards the mechanism of mitochondrial protein import. Awesome effort by Holly Ford (now banished to a one month holiday) and William Allen of ⁦@LabCollinson⁩ ⁦@BristolBiochem⁩ Will undergo another refinement before peer review. biorxiv.org/content/10.1101/…

Towards a molecular mechanism underlying mitochondrial protein import through the TOM-TIM23 complex

Mitochondria contain over a thousand different proteins, which, aside from a few encoded on the mitochondrial genome, are translated in the cytosol and targeted for import. For the majority, the...

biorxiv.org
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Collinson Lab retweeted
J Cell Science@J_Cell_Sci23 Jul 2021
Next up is our 'First person' interview with Amber Knapp-Wilson on work she performed during her PhD @LabCollinson @BristolUni @BristolBiochem, studying mitochondrial structure and function: ow.ly/IGGA50FC4oF
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We are finally enjoying our long-planned lab retreat on Dartmoor @the_gold_lab , @LabCollinson, @DaumLaboratory and twitterless Thomas Meier. Great fun!
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We have had a couple of PhD students complete their viva examinations recently. Many congratulations to @LucyTroman (@LabCollinson) and Barbara Gorda (@Berger lab) on passing your vivas. Well done to you both on completing in style despite these challenging times.
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Latest work from ⁦@LabCollinson⁩ ⁦@BristolBiochem - by team⁩ #mitochondria - amazing collaborative effort (⁦@the_gold_lab⁩ , Patty Kuwabara, Paul Verkade and Andrew Halestrap) driven by Dr Amber (Knapp-Wilson) ⁦@MitoPereira_GC⁩ journals.biologists.com/jcs/…
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Yay go @SophieL_Wills! You can also read more about her work on bacterial protein transport here: collinsonlab.squarespace.com… (shameless plug 😂)
SWBio DTP@SWBio_DTP4 Jun 2021
📢OUR STUDENTS IN THE SPOTLIGHT📢 @SophieL_Wills at @BristolUni is investigating the transport of proteins through the cell envelope in bacteria 🦠 using electron microscopy 🔬 and biochemical methods! #bacteria #electronmicroscopy Learn more here: tinyurl.com/6pnsehwd
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Boom! @LabCollinson have a brand new super-slick webpage, just gone live and in progress - fabulous job by @TiaSalter25 collinsonlab.squarespace.com
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Want to chat about why bacteria secrete proteins and how we could develop #antibiotic drugs that target this process? 🦠💊 I’ll be around 2-4pm today! Register below or DM me for a direct link to my session 👩🏻‍🔬👩🏻‍💻 #BristolRwB #scicomm
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Collinson Lab retweeted
Ian Collinson@IanofBristol2 Feb 2021
Can the bacterial Sec translocon go backwards? mbio.asm.org/content/12/1/e0… small contributions by William Allen and I @LabCollinson @BristolBiochem Very happy to be involved in collaboration with David Low @ucsantabarbara and @sannakoskiniemi @UU_University hopefully more to follow!
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ROTATION PhD - Applications for the Rotation PhD programme 2021 intake are now open. Alongside @TheSainsburyLab, our 4-year Rotation PhD offers you the chance to select 3 mini (10-week) projects in your first 8 months, before narrowing your focus 👇👇👇 okt.to/Q6wRzZ
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Karin Römisch, ⁦@alvipur⁩ , ⁦@RobinCorey1⁩ and I reviewed the recent elegant work on the structures of the EMC complex - Membrane protein biogenesis by the EMC | The EMBO Journal embopress.org/doi/full/10.15…

Membrane protein biogenesis by the EMC

The EMBO Journal - The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane...

link.springer.com
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Collinson Lab retweeted
GW4cryoEM@GW4CryoEM30 Dec 2020
Replying to @LabCollinson
@LabCollinson observed a direct interaction between the holo-translocon and the BAM machineries of bacteria, providing insights in inter-membrane organisation, communication and membrane protein biogenesis. 👉bit.ly/3htvMCL @eLife #GW4cryoEMpapers @BristolBiochem
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Collinson Lab retweeted
Ian Collinson@IanofBristol8 Dec 2020
Nice job ⁦@ryanjschulze⁩ ex ⁦@LabCollinson⁩ ⁦@BristolBiochem⁩ - published ⁦@PNASNews⁩ - seasoned publisher of high calibre science, eh Ryan! Direct lysosome-based autophagy of lipid droplets in hepatocytes | PNAS pnas.org/content/early/2020/…

Direct lysosome-based autophagy of lipid droplets in hepatocytes | PNAS

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelle-selective form of t...

pnas.org
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Collinson Lab retweeted
Argyris Politis@A_Politis12 Dec 2020
Another paper on HDX-MS has just got out - congrats to everyone contributed to this fine piece of science nature.com/articles/s41467-0…

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and...

Nature Communications - XylE is a bacterial xylose transporter and homologue of human glucose transporters GLUTs 1-4. HDX-MS, mutagenesis and MD simulations suggest that protonation of a conserved...

nature.com
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