@ryanjschulze

Chief Scientific Officer at Cytotheryx, Inc. Opinions are my own.

 Rochester, MN USA
Joined July 2009
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  • Following362
  • Followers362
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Really excited to incorporate some of these game-changing liver cell technologies into the expanding Cytotheryx pipeline! einnews.com/pr_news/61863812…

Cytotheryx, Inc. Announces Acquisition of Ambys Medicines, Inc. Intellectual Property Assets

Cytotheryx, Inc. announced today it has acquired the intellectual property assets of Ambys Medicines, Inc. These technologies will now become a part of the

einnews.com
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Amazing opportunity and group of collaborators!
Ian Collinson@IanofBristol15 Oct 2021
PhD opportunities @BristolBiochem @SWBio_DTP including a curiosity @LabCollinson : a new look at a biochemistry classic -seeking an explanation for von Heijne’s ‘positive-inside rule’ Collaboration with Paul Curnow, Will Allen, @RobinCorey1 & @RobinHoodBS2 cpb-eu-w2.wpmucdn.com/blogs.…
Excellent reading from @HenneLab just in time for the weekend!
Henne_Lab@HenneLab11 Dec 2020
Our newest work on Snx14 is online at @PNASNews! Here, we dissect mechanisms underlying neurological disease SCAR20. We find Snx14 is an important ER protein required for ER-LD crosstalk & to help maintain the cellular lipid saturation profile. pnas.org/content/early/2020/…
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Pleased to share our team’s most recent study, out now in @PNASNews! Through direct interactions with lipid droplets, lysosomes are constantly nibbling away at the fat within our liver cells! pnas.org/content/early/2020/… #NAFLD #MAFLD
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This is some mind-blowing imaging here. Stunning FIB-SEM imaging segmented using deep learning to analyze the subcellular organization of liver tissue from lean vs. obese mice. Beautiful work from @gparlakgul, @apsarruda, @ghotamis et al. @HHMIJanelia
Ana Paula Arruda@apsarruda19 Nov 2020
Happy to share our work. We have conducted a deep exploration of organelle architecture in liver tissue and related architectural regulation to function. @gparlakgul @ghotamis @HHMIJanelia biorxiv.org/content/10.1101/…
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Another really interesting preprint, this one from @LabVanni using molecular dynamics simulations to reveal the mechanism whereby seipin gathers not only TAG (but also DAG!) to promote lipid droplet biogenesis at ER tubules.
VanniLab@LabVanni28 Oct 2020
Happy to share a new preprint from the lab on one of the hottest topics in the lipid droplet (LD) community: the role of seipin in LD formation! In collaboration with the Shinoda lab in Nagoya, Japan. #lipiddroplets #seipin #moleculardynamics (1/10) biorxiv.org/content/10.1101/…

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

Lipid droplets (LD) are intracellular organelles responsible for lipid storage, and they emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly triglycerides (TG),...

biorxiv.org
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Beautiful work as always. I could stare at the imaging in this preprint for days!
Veijo Salo@VeijoS27 Oct 2020
Super excited to share our most recent work on seipin and its function in LD biogenesis biorxiv.org/content/10.1101/…

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane

Seipin is a disk-like oligomeric ER protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to...

biorxiv.org
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An excellent opportunity for anyone wishing to do some cutting-edge science with two top notch mentors in beautiful Bristol swbio.ac.uk/advancing-the-fr…
Ian Collinson@IanofBristol14 Oct 2020
Check out this - PhD with dream team supervisors - for discovery and intrigue: life in the scientific fast lane
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I took an 85 megapixel shot of the moon last night by blending together 24,000 individual image frames. #astrophotography #opteam #space
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Online Now: Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1 dlvr.it/RMDJyX
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Turns out these “tracks” are the microtubules running along the membrane in the AIS! Look at the small fluorescent blobs contacting the MTs on these correlative STORM/PREM images - these are ankyrin G tails! it's incredible to actually *see* this 🤩
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For those of you who do not know why they should follow the Twitter newbie @WittmannTorsten. Here are some micrographs of cells he has taken. I call them #Wittmanns.
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New content online! The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state dlvr.it/RDsnrK
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Metabolic imbalances between synthesis and autophagic catabolism of #LipidDroplets result in accumulation of fat in hepatocytes - a defining feature of #NAFLD. More in this review by Dr. Mark McNiven and @ryanjschulze. bit.ly/2lWxxQw
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Incredible use of AI for super-resolution microscopy by the @manorlaboratory! biorxiv.org/content/10.1101/…

Deep Learning-Based Point-Scanning Super-Resolution Imaging

Point scanning imaging systems (e.g. scanning electron or laser scanning confocal microscopes) are perhaps the most widely used tools for high resolution cellular and tissue imaging. Like all other...

biorxiv.org
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A fully funded postdoc position is available in my lab to study the mechanism of bacterial outer membrane protein assembly. For details, please see training.nih.gov/postdoc_job…
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Nice view of the storm on approach into MSP! #mnwx
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Ryan Schulze retweeted
Henne_Lab@HenneLab25 Jul 2019
Excited that our BBA review with Joel Goodman is now online. This review was spear-headed by the very talented Dr. Hanaa Hariri @hanahariri, part of the BBA "ER Platforms for Membrane Lipid Dynamics" Special Collection. #ER_literature sciencedirect.com/science/ar…
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Our new review on hepatocyte membrane trafficking is now online! Thanks to @JCellBiol for allowing us to take part in their ‘Beyond the Cell’ series! jcb.rupress.org/content/earl…
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A not-to-be-missed opportunity for anyone interested in cytoskeletal dynamics of bacteria!
Joe Lutkenhaus@JoeLutkenhaus18 May 2019
I will be looking for postdocs to continue our work on cell division in E. coli. If interested or know someone who might be interested let me know.
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