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The Peter Doherty Institute
Joined December 2016
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Grateful to the McCusker Charitable Foundation for supporting our research!
Research to investigate the how the immune system interacts with the gut microbiome has received a $1m funding boost thanks to the support of the McCusker Charitable Foundation.
Find out more 🔗 doherty.edu.au/news-events/n…
The FUTURE is bright 🤩💫 Congrats to @PiroozZareie on being awarded an @arc_gov_au Future Fellowship! 🥂
@TheDohertyInst @UniMelb @UniMelbMDHS
Honoured to be one of this year's @CancerResearch Institute's grant recipients. Incredibly grateful for their support of our important research on discovering new immunotherapeutic targets for breast cancer.
@TheDohertyInst
Congratulations Prof Laura Mackay who has secured a prestigious @CancerResearch Institute (USA) grant to advance research into novel immunotherapy targets for breast cancer. The @LMackayLab is leading the way in tissue-resident memory (TRM) cell research and how these cells can be boosted as a protective mechanism against cancer tumours.
@UniMelbMDHS @TheRMH
Thrilled to see our own @MarinaYakou in the #ASMRSpotlight! 🤩
Her research is tackling some big questions in cancer immunology—how patient-intrinsic factors like age, hormones and our microbiome influence antitumor immunity.
@TheDohertyInst @TheASMR1
June is Bowel Cancer Awareness Month. Bowel cancer is rising at an alarming rate in young people, highlighting the importance of Dr Marina Yakou’s work, an ECR from The Doherty Institute of Infection and Immunity. #ASMRSpotlight #bowelcancerawareness
Hear from our very own PI herself- Prof. Laura Mackay answers questions about everything career-related and her love for K Drama! 🤩
In our latest #PeopleandIdeas, we speak with Laura Mackay @LMackayLab @thedohertyinst about the importance of speaking up (and encouraging others to do so), gaining confidence in your career, and her uncommon introduction to science. hubs.la/Q03mgdkP0
A fun collaboration with @KaplanLab - Check out our latest review on all things skin-immunity out now in @NatImmunol 🔗👇
nature.com/articles/s41590-0…
@PiroozZareie @TheDohertyInst
Our latest study, led by @susanna_c_, shows CD47 × PD-L1 bispecific antibodies enhance tumor-resident CD8+ T cell responses, boosting anti-tumor immunity. Grateful to partner with @PfizerOncMed to advance cancer research! 🔬
@TheDohertyInst
onlinelibrary.wiley.com/doi/…
Thrilled we were part of #KSTCells25 @KeystoneSymposia in Vancouver 🇨🇦 and reunited with T cell friends & colleagues! Huge thanks to co-organizers @theLundLab, @Joshilabyale & @DelgoffeLab. We can’t wait for the next one!!
9/ We couldn’t have done it without our amazing collaborators:
@colbyzaph @LabWilhelm @LabPhan @Satpathology @tstinear @KalliesLab, our fantastic team:
@PochTobias @susanna_c_ @raissaf @DrAliZaid @PiroozZareie @TomBurn8 @MarinaYakou @simpak 🎉 @TheDohertyInst @UniMelbMDHS
8/ Together, our study shows that RA orchestrates immune memory across tissues, guiding tissue-residency and long-term surveillance. Harnessing RA’s potential could help us design therapies to boost immune protection and manage autoimmunity. 🚀
5/ We also found that RA + TGF-β work together to establish gut TRM identity. This is something we recapitulated in a dish in collaboration with @colbyzaph, whereby T cultured cells with these signals adopted TRM-like traits. 🔬
4/ The answer: T-bet controls sensitivity to retinoic acid (RA), a vitamin A metabolite essential for licensing TRM development in the gut (recently shown by @BSheridanLab). Meanwhile, liver TRM also rely on RA—instead of TGF-β—to guide their formation.
3/ In skin and liver, we previously found that T-bet enables TRM to respond to IL-15. But gut TRM thrive without IL-15 (as @JMSchenkel & @Masopust_Vezys reported). So what makes gut TRM tick?
2/ TRM protect tissues like the gut, skin, and liver, but how do they establish residency in such diverse environments? 🤔That’s the key question we tackled. #TeamTRM
1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ tissue-resident memory T cells (TRM) adopt their fate in different organs? Let’s dive in! 🧵👇
authors.elsevier.com/c/1jw~j…
🌟It was great to welcome Charlie, winner of @girlsinSTEMkit "She Did What?” competition to @TheDohertyInst for a tour! We love opportunities to meet with future #STEM superstars in our high schools who share our passion for science 🔬 🧫
🌎🌟 This work wouldn’t have been possible without amazing collaborators @Stanford @Satpathology @CalebLareau @HowittLab and our incredible research team @maxevrard @ObersAndreas @PiroozZareie
By revealing the epigenetic blueprint of memory T cells our work will help inform the design of new therapies that can modulate tissue immunity 💉 #epigenetics #Tcellblueprint #TeamTrm
Interestingly, terminally exhausted cells share accessible regulatory elements with TRM cells but possess unique epigenetic features, highlighting their distinct functional states 💡