@LabWilhelm

Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn

 University of Bonn
ukbonn.de/42256BC8002AF3E7/direct/ag-wilhelm-klinische-chemie-und-klinische-pharmakologi
Joined December 2019
  • Tweets242
  • Following444
  • Followers1.1K
23Media
How does obesity disrupt ILC2 function and adipose tissue hoemostasis? In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.
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We show that excess lipids in obesity suppress ACC1 in adipose ILC2s. Our findings also point towards an unexpected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance. cell.com/cell-metabolism/ful… cell.com/cell-metabolism/ful…

Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health

Karagiannis and Theodorou et al. show that excess lipids in obesity impair adipose ILC2s via acetyl-CoA carboxylase 1 (ACC1). Deletion of ACC1 disrupts the citrate shuttle and the NAD+/NADH balance,...

cell.com
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Congratulations to first authors @Fokaragiannis and Rafa Theodorou
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Our findings also point towards an unexected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance. cell.com/cell-metabolism/ful…

Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health

Karagiannis and Theodorou et al. show that excess lipids in obesity impair adipose ILC2s via acetyl-CoA carboxylase 1 (ACC1). Deletion of ACC1 disrupts the citrate shuttle and the NAD+/NADH balance,...

cell.com
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Congratulations to first authors @Fokaragiannis and Rafa Theodorou!
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New! Online now: Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health dlvr.it/TVcSWf
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Wilhelm Lab retweeted
SchabbauerLab@SchabbauerL
May 18
We are excited to see our beloved study on Macrophage Arginine metabolism in Neuroinflammation published today in #NatureImmunology. nature.com/articles/s41590-0…. It is time to celebrate 🍷🍻🥂

Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

Nature Immunology - Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune...

nature.com
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Wilhelm Lab retweeted
Wen Zhang@wenzhang1120
Feb 12
Honored to see our recent Nature study on neuro-epithelial circuits in anti-helminth immunity highlighted in this excellent News & Views. Many thanks to the authors @LabWilhelm for the thoughtful synthesis. doi.org/10.1038/s41590-026-0…
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A nice write-up from Nature Immunology about our recent paper! nature.com/articles/s41590-0…

Tuft cells feel the pain

Nature Immunology - Type 2 immunity in the gut is regulated by an interplay between epithelial and immune cells. A recent Nature paper shows that pain receptors amplify this response by promoting...

nature.com
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Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione synthesis to prevent #ferroptosis and support #lipid metabolism and expansion of type 2 immune cells in #asthma.
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Our new paper out in @ImmunityCP Congratulations to first author Chantal Wientjens! cell.com/immunity/fulltext/S…

Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic...

Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent...

cell.com
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Wilhelm Lab retweeted
Immunity@ImmunityCP
10 Dec 2025
Online now: Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation dlvr.it/TPlGbt

Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic...

Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent...

cell.com
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Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation | Nature Immunology nature.com/articles/s41590-0…

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoprolifer...

Nature Immunology - Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft...

nature.com
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Alaaf!! 🎊🍾🥳🥳🥳
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We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.
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Thrilled to announce that our #SFB1454 got funding @UniBonn @IIIBonn #Metaflammation
DFG public | @[email protected]@dfg_public
25 Nov 2024
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️dfg.de/de/service/presse/pre…
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Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists. @UniBonn @ImmunoSens
DFG public | @[email protected]@dfg_public
25 Nov 2024
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️dfg.de/de/service/presse/pre…
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Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando @TimMcCulloch nature.com/articles/s41467-0…
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🚨 last weeks 🚨 1 phd position available in our Lab ! If you are interested in tumor immunology and immunometabolism contact us … info 👇 … 🙏 RT
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Congratulations Anna, Ari and colleagues, really love the story!
Anna Molofsky@AnnaMolofskyLab
1 Nov 2024
Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science science.org/doi/10.1126/scie… @jerika_barron @ Nick Mroz

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits....

science.org
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