@LDLord13

brain dynamics • networks • complex systems • consciousness • @UniofOxford • @CIHR_IRSC • @HertfordCollege • @HedoniaResearch 🇨🇦🇬🇧🧠

 Oxford, England
linkedin.com/in/ldlord13/
Joined August 2018
  • Tweets179
  • Following374
  • Followers162
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Covert Consciousness in the ICU A review in collaboration with @Menon_Cambridge Thank you @CritCareMed for highlighting this topic, now even more relevant after yesterday's @NEJM paper (nejm.org/doi/full/10.1056/NE…) journals.lww.com/ccmjournal/… @MGHNeuroICU @MGHNeuroSci @MGHNeurology

Cognitive Motor Dissociation in Disorders of Consciousness | NEJM

Patients with brain injury who are unresponsive to commands may perform cognitive tasks that are detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phen...

nejm.org
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The brain is metabolically hungry but most accounts of cognition do not consider the energy cost of neural activity Here we review the metabolic budget of neural homeostasis + cognition; associated evolutionary constraints; plus disturbances in disease osf.io/preprints/osf/m5jze
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'Unravelling consciousness and brain function through the lens of time, space, and information' by Andrea Luppi @loopyluppi, @_Fernando_Rosas, @PedroMediano, Athena Demertzi @ADemertzi, David Menon @Menon_Cambridge & Emmanuel Stamatakis @estamatakis cell.com/trends/neuroscience…
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Latest one out! Ultrafast, lossless analysis methods for high-dimensional time-series - application to neuroimaging. First for @GAlteriis, congrats for seeing it over the line :-) and with @FranHancock1, @eilidhmacnicol, @brain_kcl, Federico Turkheimer
Imaging Neuroscience@ImagingNeurosci23 Mar 2024
New paper in Imaging Neuroscience by Giuseppe de Alteriis, Federico E. Turkheimer, et al: EiDA: A lossless approach for dynamic functional connectivity; application to fMRI data of a model of ageing doi.org/10.1162/imag_a_00113
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Prognostication in the ICU is an uncertain art and science. With @dbfisch, we review the state-of-the-science in our field and where we are heading in @JAMANeuro: jamanetwork.com/journals/jam… @MGHNeuroICU @MGHNeuroSci @MGH_CNTR @PennNeurology @CuringComa

Current and Emerging Approaches to Coma Prognostication After Acute Brain Injury

This narrative review evaluates the current and emerging landscapes of prognostic markers of neurologic recovery from disorders of consciousness caused by severe, acute brain injury.

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Psychedelics have started to show promise for treatment of depression. We wanted to understand what causal mechanisms are relevant in driving this success. Our latest brain comms paper attempts to shed light on it. academic.oup.com/braincomms/…

Brain dynamics predictive of response to psilocybin for treatment-resistant depression

Vohryzek et al. investigated the effects of psilocybin therapy on depression. They employed brain modelling and uncovered crucial regions involved in resto

academic.oup.com
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New paper out investigating the effect of anesthesia-induced loss of consciousness on the integration/segregation balance (tinyurl.com/5bsy28vd) lead by the fantastic @LDLord13, with @teo121270, @henrique_frnnds and Federico Turkheimer, supported by @imera_amu
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New preprint! This is the last chapter for my PhD dissertation to see the light of day: I wrote it to be an accessible introduction to information theory explicitly written for the aspiring complex systems scientist. 1/n arxiv.org/abs/2304.12482

Information Theory for Complex Systems Scientists

In the 21st century, many of the crucial scientific and technical issues facing humanity can be understood as problems associated with understanding, modelling, and ultimately controlling complex...

arxiv.org
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What is the best test to detect consciousness in the ICU? Behavioral exam? fMRI? EEG? Or is it TMS-EEG? We discuss the potential for TMS-EEG measurements of brain complexity to improve care for patients with severe brain injuries in the ICU. link.springer.com/article/10… @CuringComa
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How to do a principled stimulation paradigm? We argue for "Dynamic Sensitivity Analysis" where in-silico whole-brain perturbations are leveraged in guiding experiments. sciencedirect.com/science/ar… @Joana_Cabral__ @Castaldo_Fr @ysanz6 @LDLord13 @henrique_frnnds @LitvakVladimir
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Big paper day! Our first data showing that fMRI can be used diagnostically and prognostically in acutely unresponsive patients in the ICU. @lorettaenorton @karnig_kazazian @jpeelle @DebickiDerek @daviniaferes and others (not on twitter). onlinelibrary.wiley.com/doi/…

Functional Neuroimaging as an Assessment Tool in Critically Ill Patients

Objective Little is known about residual cognitive function in the earliest stages of serious brain injury. Functional neuroimaging has yielded valuable diagnostic and prognostic information in...

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Brain rhythms have been detected for a century, but their generative mechanisms remain under debate. Here's our hypothesis and how we tested it (1/6) nature.com/articles/s42005-0… @Castaldo_Fr @VohryzekJakub @LitvakVladimir @RenaudLambiotte @BickMath, Friston, Kringelbach & Deco

Metastable oscillatory modes emerge from synchronization in the brain spacetime connectome

Communications Physics - The mechanisms underlying transient brain rhythms and weekly stable synchronization of distant brain areas and their link with neural activity is still a matter of debate....

nature.com
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The ultimate test of your knowledge is your ability to convey it to another.
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New preprint out: "Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness" biorxiv.org/content/10.1101/… With the legendary: @LDLord13 @teo121270 @henrique_frnnds and Federico Turkheimer and support from @imera_amu

Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness

In recent years, brain imaging studies have begun to shed light on the neural correlates of physiologically-reversible altered states of consciousness such as deep sleep, anesthesia, psychedelic...

biorxiv.org
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"Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness" 🧠 in collaboration with: @ExpertPol @teo121270 @henrique_frnnds and Prof. Federico Turkheimer supported by @imera_amu 🇫🇷 biorxiv.org/content/10.1101/…

Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness

In recent years, brain imaging studies have begun to shed light on the neural correlates of physiologically-reversible altered states of consciousness such as deep sleep, anesthesia, psychedelic...

biorxiv.org
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Ketamine gets a lot of attention, but I don't think we put enough emphasis on how crazy it is that a single molecule can take you from rich dissociative hallucinations to complete anesthetic oblivion, with dynamics comparable to both classical psychedelics & GABAergic anesthesia.
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The bad news is not everyone will agree with your opinions or decisions. The good news is it doesn't matter.
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L.D. Lord retweeted
Jacobo Sitt@jdsitt18 Mar 2022
A long-waited paper coming from our long term collaboration with Bechir Jarraya's lab. This time we used DBS to induce anesthesia awakening. We measured the impact in behavior, static/dynamic fMRI FC, and EEG. A proper thread next monday! science.org/doi/10.1126/scia…

Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate...

Thalamic stimulation restores behavioral and brain-imaging signatures of consciousness in anesthetized macaques.

science.org
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Metronomes on a rolling platform will naturally synchronize. Wait for it. The math is described by the Kuramoto model, also used to describe synchronization in populations of neurons. Video source: wesphysdemo, wikipedia en.wikipedia.org/wiki/Kuramo…
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Frustrated Kuramoto model on simplicial complex: mathematical framework, generalised order parameter and complex dynamics: endless fun in sight. Thank you @arnaudon, @RobertPeach15 and @lordgrilo for seeing it through! arxiv.org/abs/2111.11073

Connecting Hodge and Sakaguchi-Kuramoto: a mathematical framework...

We formulate a general Kuramoto model on weighted simplicial complexes where phases oscillators are supported on simplices of any order $k$. Crucially, we introduce linear and non-linear...

arxiv.org
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