@LCBM_EPFL

Laboratory of Biophysical Chemistry of Macromolecules (LCBM) headed by @Beatfierz at @EPFL_EN ¦ run by LCBM members

 Lausanne
epfl.ch/labs/lcbm/
Joined August 2021
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  • Following264
  • Followers349
36Media
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 nature.com/articles/s41467-0… (1/8) #ChemBio
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This would not have been possible without the excellent (and very efficient!) contributions of @BabatundeEkund1 and Polina Foteva (who just defended her MSc thesis 🥳), of @DongchunNi, Esther Calviño and @LabStahlberg, or without the truly supportive guidance of @Beatfierz. (7/8)
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Always nice to share the ideas together! Many THX to who show interest and ideas in our project 🙏 If interested in TF target search, feel free to contact us 📧 @LCBM_EPFL @davidsuter_epfl THX to the EMBL travel grant for me to attend such great conf. 🍀 #EMBLOmics @EMBLEvents
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Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society @KingsCollegeLon pubs.acs.org/doi/10.1021/jac…

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward...

Abstract. Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of

pubs.acs.org
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🎓🌟 Congrats to this year’s grads! Wishing our 6 incredible master's students in #ChemicalBiology all the best in their future adventures! #MasterThesis #ChemBio @unige_en @EPFL_en
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Have a look @ChemRxiv on a new class of peptide-cyanobenzene dye photocatalysts developed by @Xingyuu_Liu in collaboration with Dr. Anne Sophie Chauvin and Wei Cai/ @Beatfierz @LCBM_EPFL - go.shr.lc/40UFl6w
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Inhibitors of histone deacetylases (#HDACs) have longer and longer on-target residence times, which may help future clinical applications. How is this achieved? Check out our new #OpenAccess Perspective @JACS_Au, with @DrYasirRaouf, to know more! 👇🏻 pubs.acs.org/doi/full/10.102…

Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

Abstract. The dysregulated post-translational modification of proteins is an established hallmark of human disease. Through Zn2+-dependent hydrolysis of ac

pubs.acs.org
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Doping, but make it biocatalysis! I’ve had an amazing time collaborating with @andexerlab at ALU Freiburg on this project we’re happy to have published in Angewandte Chemie. doi.org/10.1002/anie.2024145…

Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevi...

S-Adenosylmethionine-dependent methyltransferases are emerging enzymes for selective biocatalytic alkylation. Introduction of the direct sulfurylation pathway from S. cerevisiae improved methylation...

onlinelibrary.wiley.com
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A Site-Specific #ClickChemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168 (Beat Fierz and co-workers) @_paulinefranz, @Beatfierz, @EPFL_en #openaccess onlinelibrary.wiley.com/doi/…

A Site‐Specific Click Chemistry Approach to Di‐Ubiquitylate H1 Variants Reveals Position‐Dependent...

We developed a click chemistry approach to di-ubiquitylate histone H1 at relevant DNA repair-associated positions (H1KxUb2) to probe its effect on the E3 ligase RNF168. We demonstrate that H1KxUb2...

onlinelibrary.wiley.com
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Happy to see our latest work in @ChemEurJ 🎉. Here we present a new way to get a photoactivatable BODIPY for cell imaging. This probe allows super-resolutive images in the green channel. Special thanks to @vleberruyer, Maxence, Pascal and @Mayeul_Collot doi.org/10.1002/chem.2024034…

Targeted Photoactivatable Green‐Emitting BODIPY Based on Directed Photooxidation‐Induced Activation...

PFB is an efficient, green-emitting, photoactivatable probe based on BODIPY. Upon irradiation with visible light (488 nm), directed photooxidation oxidizes the furanyl group and eliminates the...

chemistry-europe.onlinelibrary.wiley.com
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The mammalian Zn-dependent #HDACs are very diverse. They target various acyl-lysine modifications and acetylation of polyamines and other molecules. This study led by Michael Lammers and Leonie Graf @uni_greifswald trace these features in bacteria🦠! nature.com/articles/s41467-0… 1/6
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I am really excited to share our latest #sirtuin research on @biorxivpreprint! We used mechanism-based crosslinking to solve the structure of SIRT7 and its interaction with biological substrates on the nucleosome. More details to follow 🙂
bioRxiv Biophysics@biorxiv_biophys11 Oct 2024
Structural basis of SIRT7 nucleosome engagement and substrate specificity biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by @AlexaTeslenko at @EPFL_CHEM_Tweet, a tour-de-force of single-molecule enzymology! biorxiv.org/content/10.1101/…

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Chromatin regulation relies on ‘writer’ enzymes that add post-translational modifications (PTMs) to histone proteins. Variant Polycomb repressive complex 1 (PRC1) exists as several subtypes, which...

biorxiv.org
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We've got some fantastic news: Andrei won the runner-up Best Contributed Talk award🏆 at the @SwissChemistry Summer School Chemical Biology, and congratulations to Enguerran, who successfully passed his Candidacy exam. 🎉
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🔋Recharging just before the beginning of the autumn semester: this year's group outing featured stunning views and a relaxing afternoon at the #Oeschinensee shores 🏞️ Welcome to our new LCBM member @ShaswatiMandal, who joins as a Postdoctoral Researcher!
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It was a pleasure to present at the SCS Fall Meeting today and learn about all the fantastic Swiss MedChem and ChemBio research! @SwissChemistry @SCS_DMCCB
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A warm welcome to our new LCBM members (left to right) @SaladinLazare and @PatriciaBencic who joined as PostDocs, and @MatteoDoudin who started his PhD with us. We're happy to have you - all the best! 🧪🧫⚗️
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Health Horizons: exploring the future of medicine 💊👩‍🔬 with Ekaterina Pyatova (@EPFL_CHEM_Tweet), @AngelaSteinauer (@EPFL_CHEM_Tweet) and Erick García-Cordero (@ReaDiagnostics) #PINT24 @pintofscienceCH @befcorreia @SteinauerLab
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Registration is open! Join us in October for our quadrennial international #chromatin symposium in Munich. Hear and meet amazing guest speakers, and present your own work. Details at sfb1064.med.uni-muenchen.de/…
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Great talk by our @CarlosMYruela at the @EPFL_en #chromatinatthelake seminar series presenting mechanistic insights in histone deacetylation using semi-synthetic histones. #chembio
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