@SimSakong

Physicist in Life Science / Ph.D. in Quantitative Biology / Postdoc in Hansen lab, MIT

 Cambridge, MA
Joined July 2021
  • Tweets32
  • Following205
  • Followers82
4Media
Exciting research update! 🎉 Together with @Beatfierz and @davidsuter_epfl, we explored how charge in disordered regions flanking DBDs influences target search and pioneering activity. Check it out! 👇 biorxiv.org/content/10.1101/…

Electrostatic properties of disordered regions control transcription factor search and pioneer...

Transcription factors (TFs) recognize specific target sites to control gene expression. While prokaryotic TFs combine 1D and 3D diffusion to efficiently locate their binding sites, the target search...

biorxiv.org
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Always nice to share the ideas together! Many THX to who show interest and ideas in our project 🙏 If interested in TF target search, feel free to contact us 📧 @LCBM_EPFL @davidsuter_epfl THX to the EMBL travel grant for me to attend such great conf. 🍀 #EMBLOmics @EMBLEvents
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New science awaits! ✨ We are excited to introduce you to our brand-new 2025 EMBL Annual Poster ➡️ embl.org/about/info/course-a… In 2025, you can look forward to novel meetings such as the EMBO | EMBO Symposium 'Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer', as well as tried and true classics like #EMBLCanGen 🙌 #molecularbiology #lifesciencetraining #lifesciences
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Sim Sakong retweeted
LCBM@LCBM_EPFL21 Jan 2024
How did #chemicalbiology approaches empower the study of chromatin #ubiquitylation? Find out more about recent progress that paves new ways to address challenges in chromatin (poly)ubiquitin signaling. 👉#OpenAccess review by @_paulinefranz & @Beatfierz: doi.org/10.1016/j.jmb.2024.1…
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Sim Sakong retweeted
Beat Fierz@Beatfierz12 Dec 2023
Check out our work on centro-chromatin, where CENP-A and CENP-B collaborate to generate a dynamic chromatin state! A great collaboration between Nikolina Sekulic’s lab & us @EPFL_CHEM_Tweet, @LabHalic and @tatsuofukagawa1. Congrats Harsh and Ahmad! nature.com/articles/s41467-0…
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Beat Fierz@Beatfierz16 Dec 2023
Impressions from the LCBM Xmas party.!Happy holidays!!! 🎄🎁🎅🏽
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Sim Sakong retweeted
Beat Fierz@Beatfierz9 Jan 2024
Check out the new review from @CarlosMYruela on the using synthetic chromatin to investigate the function of histone deacylases! doi.org/10.1042/BST20230693
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LCBM@LCBM_EPFL5 Apr 2023
Today we’re celebrating with self-made 🇨🇳🇹🇼🇰🇷 hot pot! Thanks to the chefs!
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Happy to share this Hypothesis paper from Benjamin Martin, 2nd year PhD student onlinelibrary.wiley.com/doi/…. 🧵

An out‐of‐equilibrium definition of protein turnover

We propose a new definition of protein turnover (PT) that allows for determining PT in dynamic biological processes. We developed guidelines and a ready-to-use set of equations that we applied to...

onlinelibrary.wiley.com
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Mark it in your #BPS2023 planner! Sunday Feb. 19 @beatfierz (EPFL) will be describing his work using #singlemolecule colocalization imaging and #smFRET to directly observe the dynamic architecture of chemically defined chromatin fibers. tinyurl.com/biophys23 for more details.
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Come and see the new findings on my work, “Target Search Dynamics Of Sox Transcription Factors” 📰📊if you are in #SanDiego for #BPS2023 @BiophysicalSoc 🗓️ Sunday 1.45 - 3.45 PM 📍 Exhibit Hall BC B184 Protein-Nucleic Acid Interactions I
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Sim Sakong retweeted
Beat Fierz@Beatfierz3 Dec 2022
Our paper made it onto the cover on Genes & Devlopment! Check it out here: genesdev.cshlp.org/content/3…
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Interested in cell lineage predictions ? @AlmutEisele will be discussing GEMLI to predict lineages solely from scRNA-seq datasets #EMBOOmics - Tomorrow at 18:10 biorxiv.org/content/10.1101/…

Barcode-free prediction of cell lineages from scRNA-seq datasets

The integration of lineage tracing with scRNA-seq has transformed our understanding of gene expression heritability during development, regeneration, and disease. However, lineage tracing is techni...

biorxiv.org
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How do cells regulate changes in protein expression levels upon external stimulation? Happy to share our new preprint addressing this question, by super-talented PhD student Benjamin Martin biorxiv.org/content/10.1101/… A brief 🧵

Flux analysis reveals specific regulatory modalities of gene expression

The level of a given protein is determined by rates of mRNA and protein synthesis and degradation. The reliable quantification of these rates is thus essential to understand how protein levels are...

biorxiv.org
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I am still wondering whether the creators of ChatGPT are aware that in French, it means : Cat, I farted
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Sim Sakong retweeted
LCBM@LCBM_EPFL9 Dec 2022
Happy holidays from LCBM🎄🎁 The weather is snowy, the vin chaud is good and all are well. Take care and see you next year, oh wait no, group meeting on Monday
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Excellent talk by @Beatfierz using semisynthesis to dissect dynamic protein regulation by post-translational modifications #ISCB2022 @NCCR_ChemBio
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Sim Sakong retweeted
LCBM@LCBM_EPFL8 Nov 2022
Great Korean dinner concluding an exciting first day at @NCCR_ChemBio #ISCB2022 in Geneva. Come check out our posters tomorrow!
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Beat Fierz@Beatfierz20 Sep 2022
How to crack the tubulin code? Check out the new story from us @EPFL_CHEM_Tweet & @AumeierLab @UNIGEnews on the development of semisynthetic tubulin, now out on bioRxiv! A great collaboration with the lab of Pierre Gönczy @epflSV & many more... biorxiv.org/content/10.1101/…
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LCBM@LCBM_EPFL1 Sep 2022
👋Welcome @CarlosMYruela who joins us as visiting researcher funded by @DFF_raad 🇩🇰. He'll work on visualising enzyme activity on chromatin, and we're excited you're here! We're also happy to welcome guest PhD student Mina Hanna for 3 months as part of #MSCA @BioInspSensing.
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