@Kueh_Lab

Associate Professor @Yale Immunobiology and Center for Systems and Engineering Immunology. Interested in understanding and engineering immune cell circuitry.

 New Haven, CT
Joined May 2018
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  • Following518
  • Followers803
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So proud to share our work on memory T cell generation, now out in @ImmunityCP! This huge paper is the heroic work of @kathleenabadie, @elisacclark and Raj Valanparambil from @rafiahmed_lab.
kathleenabadie@kathleenabadie31 Jan 2024
It’s a big day for us today as we share the @Kueh_Lab’s latest work, just out in @ImmunityCP . We set out to understand how memory T cells form, and we found remarkable flexibility in their lineage pathways from naive progenitors: authors.elsevier.com/c/1iWf0…
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Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no role.
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Trump's proposal is ILLEGAL & amounts to an indiscriminate funding cut for research centers of all sizes, NOT just Ivies. It will mean shuttering labs across the country, layoffs in red & blue states, & derailing lifesaving research on everything from cancer to opioid addiction.
NIH
@NIH7 Feb 2025
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.
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NIH indirect costs fund the backbone of research: maintaining labs, ensuring safety, and supporting admin work. These are essential for groundbreaking discoveries. Drastic cuts to NIH indirect rates are detrimental to academic biomedical research.
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⁦@elonmusk⁩ guess whose catching up fast? Instead of supporting AMERICAN science you want to cripple our thriving biomedical economy
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NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country. Brief explainer for those not in this world: buff.ly/3EtML7D
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Excited to share my PhD work from @rafiahmed_lab. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for an inherently non-prescient immune system. tinyurl.com/53nrpsa6
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Second edition of the EMBO workshop on Developmental Timing across species. Second edition organized by @bassemh1 @MDiazCuadros @VanderhaeghenP2 and I. #EvoDevoTempo Cool speakers & fun networking activities organizers. More details coming soon. Save the date!
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Calling all faculty candidates (postdocs, Asst Profs, senior grad students) - Apply to @UWBioE! Job ad at link below. If you are considering applying and have questions on the ad, please email or DM me. Come join us, UW is amazing! apply.interfolio.com/155240
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🚨𝐇𝐞 𝐋𝐚𝐛 job opportunity @UCSF 🚨: I'm hiring TWO postdocs - an experimentalist and a computational biologist. Join us to use cutting-edge single-cell and spatial technologies to unravel the mysteries of human tissues. opportunities.ucsf.edu/conte…
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People like QR codes right? Scan this to find out more about the UW BioE opening for Assistant Tenure Track Professor! @UWBioE
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What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬 biorxiv.org/content/10.1101/…

Reconstructing signaling history of single cells with imaging-based molecular recording

The intensity and duration of biological signals encode information that allows a few pathways to regulate a wide array of cellular behaviors. Despite the central importance of signaling in biomedi...

biorxiv.org
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Excited for the Keystone Symposium on T Cell Differentiation in Tissue Microenvironments. #KSTCells25 Submit your abstract by Nov 5th for a chance of being selected for a short talk! Joint meeting w Innate Memory Keystone! keysym.us/KSTCells25
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Princeton's new Omenn-Darling Bioengineering Institute (@omenndarlingbio) is running multiple faculty searches this year! We are really excited to grow our bioengineering faculty & move into a brand-new building. Postdocs on the market - apply at: puwebp.princeton.edu/AcadHir…
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1/12 Check out this paper that came out last week from our pan-monogenic project, which utilizes diverse natural single-gene defects in humans to study and assess the immune health of both patients with disease or those clinically healthy. nature.com/articles/s41591-0…
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Our latest preprint which is the result of ~8 years of collaboration with the @TheHPAP is now available on bioRxiv. Our work represents the largest existing multiome measurement in pancreatic lymph nodes of humans in health and Type 1 Diabetes: biorxiv.org/content/10.1101/…
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🚨🚨🚨🚨 Our new preprint is out! “Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations” 🩸🧫🧪🧬 biorxiv.org/content/10.1101/… The superteam of @cancer_curious and Dani Fernandez tackled a major unanswered question in HSC bio. 1/

Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver...

Cancer cells display wide phenotypic variation even across patients with the same mutations. Differences in the cell of origin provide a potential explanation, but these assays have traditionally...

biorxiv.org
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Thrilled to share our work investigating the influence of tumor cell ARID1A loss on anti-tumor immunity is now out in @CellCellPress ! 🎉🎉
Cell@CellCellPress15 May 2024
Now online! ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity dlvr.it/T6xRNC

ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

ARID1A loss in tumor cells triggers anti-tumor immunity via R-loop-derived cytosolic DNA and activation of the STING-type I interferon pathway, defining a molecular mechanism underlying ARID1A mutant...

cell.com
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Super thrilled to share a preprint from the lab biorxiv.org/cgi/content/shor… We found pH regulates the inflammatory response 🔥in #macrophage by controlling BRD4-dependent transcriptional condensates. In my lab led by @younggouu
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How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s41588-0…
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Our paper @ImmunityCP reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n
Matt Mulè@MPMule2 May 2024
Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: authors.elsevier.com/c/1j0dm…
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