https://xitter.cf/t.co/k3jnFRIRuM | human immunology | PhD from @Cambridge_Uni / NIH @NIHOxCam. MD student @UNC_SOM
Joined October 2014
- Tweets382
- Following846
- Followers448
- Likes1.2K
Pinned Tweet
Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: authors.elsevier.com/c/1j0dm…
Matt Mulè retweeted
Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
Matt Mulè retweeted
1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. cell.com/immunity/abstract/S…
Check out our recent work describing how vaccination can rewire the baseline immune status of healthy individuals!
Excited to share our new paper on temporal analysis of vaccine+/- adjuvant hours to 100 days (14 time pts). Vax alone induces new baseline immune state early & persists to 100 days, and that state predicts vax responses in an indep cohort. cell.com/cell-reports/fullte….
Matt Mulè retweeted
In our new paper @PNASNews we show that previous cardiovascular disease increases susceptibility to ICI-myocarditis development by recruiting autoimmune myosin specific TRM cells to the heart!
pnas.org/doi/10.1073/pnas.23…
@DrCihakovaD @TaejoonW @AbdelDaoud20503
I'm honored to be recognized among my peers in @NIHOxCam. The program's unlimited flexibility + lack of boundaries allowed me to focus on learning & follow the science wherever it led. So grateful to @TsangLab, Ken, @plyons34 & many others for guidance bit.ly/4d24HCU 1/2
Congratulations to @MPMule for being named the 2024 Outstanding Recent Graduate Award recipient!
bit.ly/3LMAzzk
So many great institutions and people supported me over those years. The best part completing my thesis was writing the acknowledgments. Thank you all... @SidneySussex @MedCambridge @NIAIDTraining @DrAimeeLee @hollern_daniel @DrChrisHourigan @ChenZhao2011 @rohitfarmer
Imagine a patient at initial presentation with an immune-mediated disease; rather than focusing on tissue/antibody-based diagnosis, you treat based on a test that captures the patient's global immune health.
Another great step in that direction from my colleagues @tsanglab
1/12 Check out this paper that came out last week from our pan-monogenic project, which utilizes diverse natural single-gene defects in humans to study and assess the immune health of both patients with disease or those clinically healthy.
nature.com/articles/s41591-0…
Matt Mulè retweeted
#MLCB2024 deadline extended to June 17!!
MLCB2024 abstract/paper submission deadline is coming up (June 15). mlcb.github.io/
Also check out the list of fantastic keynote speakers: Maria Chikina (@ChikinaLab), Ava Amini (@avapamini), Jian Zhou (@zhou_jian), Nilah Ioannidis, Sergey Ovchinnikov (@sokrypton)
Matt Mulè retweeted
There's been amazing coverage of our new paper @Nature nature.com/articles/s41586-0… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...
It's so meaningful to share this chapter of work with my colleagues @TsangLab with my wife Sarah, who created the cover for @ImmunityCP.
Days spent working together while in grad / art school, overlooking our garden in Cambridge, were some of the happiest in my life :) 1/
New issue online! Cover depicts work from @TsangLab & @MPMule &co identifying a "naturally adjuvanted" state in individuals who respond more robustly to unadjuvanted vaccines. Artwork by Sarah Hopkins cell.com/immunity/issue?pii=…
More of Sarah's nature/biology inspired art books, prints and design work: designhops.com
May issue of immunity: cell.com/immunity/issue?pii=…
Open access link to our paper: authors.elsevier.com/c/1j0dm…
#SciArt #SciComm
Matt Mulè retweeted
Our latest @ImmunityCP paper made cover! Congrats and thanks to Sarah Hopkins for the beautiful art work. @MPMule.
New issue online! Cover depicts work from @TsangLab & @MPMule &co identifying a "naturally adjuvanted" state in individuals who respond more robustly to unadjuvanted vaccines. Artwork by Sarah Hopkins cell.com/immunity/issue?pii=…
Matt Mulè retweeted
Our collaborators develop modeling that helps identify multi-omic #immune #signatures
#bioinformatics @LeyingGuan @skleinstein @JeremyGygi @a_konstorum + others
pubmed.ncbi.nlm.nih.gov/3860…
ALT A complex workflow for a bioinformatics paper about identifying #immune #signatures. https://pubmed.ncbi.nlm.nih.gov/38603606/
Matt Mulè retweeted
Using spatial metabolic flux we identified the conditions to preserve discarded human donor kidney’s for at least 4 days ex vivo. Such an approach also holds the potential for resuscitation and could increase the window for organ allocation. rdcu.be/dHL6W
Matt Mulè retweeted
Our paper @ImmunityCP reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n
Our paper "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint" @TsangLab is now online @ImmunityCP Link to open access pdf: authors.elsevier.com/c/1j0dm…
Thank you for supporting this work @NIHOxCam @TheAlliance05 @UNCmdphd @NIAIDNews @IRPatNIH and for discussions about this work many thanks to Ken Smith, @plyons34 @teichlab @BrodinPetter @GosiaTrynka and Eoin Mckinney.
And of course many thanks owed to anonymous reviewers, @ImmunityCP, @KavithaSci for helping us improve the paper.