The Human Pancreas Analysis Program (HPAP) - Dedicated to better understanding Type 1 and Type 2 Diabetes
Joined April 2020
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HPAP member Klaus H. Kaestner was honored with the Albert Reynold prize for 2026 by the EASD, held in Milan, Italy.
The HPAP team is happy to announce the publication of our newest study and resource. Here, we perform single base resolution DNA methylation analysis of human alpha, beta and exocrine cells to map epigenomic transitions in aging and T2D. rdcu.be/ffbgE
We are happy to report that HPAP processed 5 new cases in the last 5 days - thanks so much to the tremendous efforts of our procurement team in these difficult times!
HPAP is proud to announce the publication of its new findings on a lymphotoxin beta signature in the lymph nodes and pancreas of people with T1D. sciencedirect.com/science/ar…
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Proud of this team science effort with @TheHPAP and @DiabetesnPOD. We are always grateful to the families and the funders who make this work possible. @HelmsleyTrust @BreakthroughT1D @NIDDKgov @NIAIDNews
A recent study from @UFHealth has mapped hidden immune signals involved in Type 1 diabetes, offering new insight into how the disease develops beneath the surface. By identifying these early immune patterns, researchers are moving closer to earlier diagnosis and more personalized treatment approaches.
Read the full article below.
ufhealth.org/news/2026/uf-he…
ALT This image shows the cellular structures of a human pancreatic lymph node. These lymph nodes play an important role in initiating the autoimmune attack that destroys the insulin-producing cells of the pancreas during type 1 diabetes. (Image by UF Diabetes Institute)
Visit PANC-DB - hpap.pmacs.upenn.edu - to check out all of the datasets and tools available to support your diabetes research!
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Funding Opportunity
Emerging Leader Initiative aimed at providing support and protected time for senior Postdocs seeking to pursue studies that will enhance their transition toward independent research careers.
Due May 1st
Learn more at: hirnetwork.org/emergingleade…
Please share!
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Didn’t get the grad school interview you wanted yet? Turn this year into a launchpad. The Vahedi Lab @Penn is hiring a Research Specialist A/B — ideal for undergrads & recent grads aiming for PhD/MD-PhD programs.🧬 Immunology + genomics. Apply here: tinyurl.com/2s6demtu
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We are grateful that our paper science.org/doi/10.1126/scii… in @SciImmunology is featured at Penn Today; thanks to @bfariabi @TheHPAP and all collaborators tinyurl.com/24hpe9sy
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A study co-led by @golnaz_v, @PennGenetics, finds new clues in pancreatic lymph nodes and the spleen that could help detect—and even stop—Type 1 diabetes. @SciImmunology spr.ly/60107Y33o
ALT Young man measuring insulin level at home.
New work from HPAP! Immune cells ‘caught in the act’ could spur earlier detection and prevention of Type 1 Diabetes - pennmedicine.org/news/early-…
HPAP has now processed case #200! Thank you to the donors and their families. All data can be found on PANC-DB at hpap.pmacs.upenn.edu
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In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: nature.com/articles/s42255-0…
HPAP has added 136 new bulk RNA-seq datasets to PANC-DB! Explore here: hpap.pmacs.upenn.edu/
HPAP now has CODEX data available from 148 donors on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore…
Please check out our @HIRN_CC webinar “Introduction to the New Islet Function Portal on PANC-DB" here: youtube.com/watch?v=UdcauFgn…
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New research published in Nature Communications with UFDI collaborators Dr. Melanie Shapiro, Dr. Mark Atkinson, and Dr. Todd Brusko reveals immune cell disruptions in pancreatic lymphatic tissues may precede Type 1 Diabetes onset—offering key insights into early detection and intervention. Click here to read more pmc.ncbi.nlm.nih.gov/article…
@Mel_Shapiro_PhD @matkinsonT1D @Bruskolab @UFMedicine @UFHealth @NatureComms
The Human Pancreas Analysis Program - HPAP retweeted
🚨New work from our lab with important clinical implications. Thanks to our collaborators in @TheHPAP. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv biorxiv.org/content/10.1101/…
Two new, NIH funded postdoc positions are available! (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans - please send CV and names of references to: [email protected]