@Khare_Lab

We are a group of protein and enzyme designers using computational and experimental techniques to develop new molecules for tackling 21st-century challenges

 Rutgers University
sagardkharelab.org
Joined December 2014
  • Tweets38
  • Following94
  • Followers137
"You've got to love the PDB" - RCSB PDB Director at #IUCr2023 Protein Data Bank: From Two Pandemics to the Global Pandemic to mRNA Vaccines and Paxlovid highlighted collaborations with Joey Lubin, @Khare_Lab, @sagardkhare, and two summers of @RISErutgers students
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Modeling of ACE2 and antibodies bound to SARS-CoV-2 provides insights into infectivity and immune evasion: buff.ly/3K1l06d @Khare_Lab @RutgersCancer #COVID_19
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I’m looking for a postdoc who wants to work with me and Andrew Kruse to design and characterize new protein sensors! If you’re interested or have any leads, let me know!
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Interested in protein design, deep learning, computational biophysics? Or computational RNA folding, vaccines, enzymes, antibodies, biomaterials, machine learning? Become a @RosettaCommons undergraduate summer intern (@NSF #REU) or a postbaccalaureate fellow (#RaMP)! [thread!]
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Replying to @AMartinezArias @cshperspectives @eLife
that's the idea - we are intentionally redefining what eLife means - it means high-quality, constructive REVIEWS - not high-quality papers
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These analyses of BA.2.75 relied on open data sharing from scientists in India, Japan, Singapore and the US. We're still seeing remarkable evolution of SARS-CoV-2 with new variants emerging and spreading rapidly making continued global genomic surveillance essential. 10/10
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My group at @HMS_BCMP and @DFCI_ChemBio is looking for a new postdoc with an interest in developing deep learning algorithms for ligand-binding protein design. Can start immediately. DM or email me if interested!
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We will continue battling against misinformation, disinformation and hate speech. We will keep working towards promoting critical thought in society. We are here to stay. 3/3
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Read "Evolution of the SARS-CoV-2 proteome in three dimensions during the first 6 months of the #COVID19 pandemic" by Sagar Khare, Stephen Burley, et al. ⭐ Included in Proteins' #COVID19 Special Issue. ow.ly/lNUr50K03yU @buildmodels @RISErutgers @BLbiochem @Khare_Lab
Research on COVID-19 - Read it now.

ALT Research on COVID-19 - Read it now.

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The first story from our lab @NCIResearchCtr led by postdoc @zanyzarr is out in @PLOSBiology ! journals.plos.org/plosbiolog…

Systematic identification of molecular mediators of interspecies sensing in a community of two...

Bacteria typically exist in dynamic, multispecies communities where polymicrobial interactions influence fitness. This study uses an unbiased genome-scale approach to reveal multiple Staphylococcus...

journals.plos.org
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We can’t let this continue. Access to abortion is a human right.
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Pleased to share our recent work with @Khare_Lab and @darrinyork_lbsr "Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign" pubs.acs.org/doi/10.1021/acs…

Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme...

Abstract. DNA polymerases have evolved to feature a highly conserved activity across the tree of life: formation of, without exception, internucleotidyl O–

pubs.acs.org
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Khare Lab retweeted
Fasan Lab@FasanLab16 Jun 2022
Excited to share our latest paper on asymmetric cyclopropanation with phosphonyl diazo compounds using engineered myoglobins. Congrats to the lead author Xinkun (starting his lab at Nanjing University) and the other coauthors in our lab and in @Khare_Lab! pubs.rsc.org/en/content/arti…

Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered...

Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial age

pubs.rsc.org
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Want to enhance the thermostability of your enzyme without impacting its catalytic function? Check out this expanded #toolbox of genetically encoded amino acids to make thioether “staples”, from @FasanLab @Khare_Lab @AndoLab.  pubs.acs.org/doi/10.1021/acs… #rosetta #design
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Khare Lab retweeted
Fasan Lab@FasanLab26 May 2022
Excited to share our work on the use of computational design and non-canonical AA for enzyme thermostabilization via covalent 'stapling'. Congrats to lead authors Jake and John and all coauthors! Great collaboration with @Khare_Lab and @AndoLab! 🎊 pubs.acs.org/doi/10.1021/acs…

Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of...

Abstract. Enhancing the thermostability of enzymes without impacting their catalytic function represents an important yet challenging goal in protein engin

pubs.acs.org
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Our COVID-19 exploration now has a volume and page numbers! Many thanks to the students and teachers of @RISErutgers and @BLbiochem and @Khare_Lab for making this possible! rcsb.org/news/62545908c8eabd…

Paper Published: Evolution of the SARS-CoV-2 proteome in 3D

Part of a SARS-CoV-2 special issue for Proteins, this article began with a Boot Camp and undergraduate summer research program in 2020.

rcsb.org
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Massively excited that this is finally out! Work led by former postdoc Brahm Yachnin. @Khare_Lab @RutgersChem With @lauraazouz via @RosettaCommons; @RalphWhiteIII Drake lab Massively parallel, computationally guided design of a proenzyme pnas.org/doi/10.1073/pnas.21…
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Khare Lab retweeted
Fasan Lab@FasanLab2 Feb 2022
Check out our latest work on a novel biocatalytic method for the asymmetric synthesis of organofluorine compounds! Congrats to Albert, Antonio, Ron and the Sagar team @Khare_Lab @RutgersChem @URochesterChem #organofluorines #biocatalysis pubs.acs.org/doi/10.1021/jac…

Enantioselective Synthesis of α‑Trifluoromethyl Amines via Biocatalytic N–H Bond Insertion with...

Abstract. The biocatalytic toolbox has recently been expanded to include enzyme-catalyzed carbene transfer reactions not occurring in Nature. Herein, we re

pubs.acs.org
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Nobel Renews Debate on Chinese Medicine nyti.ms/1Zp4S0c

Nobel Renews Debate on Chinese Medicine (Published 2015)

When Tu Youyou, a retired researcher of a Chinese medicine academy, won China’s first Nobel in science, it raised old questions on tradition.

nytimes.com
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Khare Lab retweeted
nature
@Nature11 Oct 2015
Diagnostic developers target antibiotic resistance ow.ly/Tey4X
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