I also left mid-career during an exciting moment (I’d just moved the lab and was just ramping up in a stimulating new environment that was a stellar scientific fit). So swapping jobs/sectors at the time was a lot more pull than push. But while I was doing my job exactly as I wanted, I was still putting one foot in front of the other on what felt like a pre-determined trajectory. IMO, a totally valid reason to change course is to look anew at the world as it is today (frankly right now feels like the most exciting time in science in my lifetime), and actively re-evaluate whether you still want to be on the path you decided on 10+ years ago. I think it’s ok to keep opting into our lives. That way even if we keep doing what we’re doing, it’s on purpose.