@JenTekle

Postdoc @theGarrettLab @HarvardChanSPH | Cancer Biology | Tumor microenvironment | Microbiome | PhD🇨🇭@IOR_Bellinzona @unil | 🇱🇧🇫🇷 in 🇺🇸

 Boston, MA
Joined July 2020
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  • Followers210
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And that’s a wrap! Very happy to share our review on the fascinating and multifaceted role of the microbiota in cancer. 👇 1/3 nature.com/articles/s41568-0…

Bacteria in cancer initiation, promotion and progression

Nature Reviews Cancer - The role of the microbiota in tumorigenesis has garnered considerable attention over the past two decades. In this Review, El Tekle and Garrett explore the current and...

nature.com
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Jennifer El Tekle retweeted
Garrett Lab@theGarrettLab2 Nov 2025
Check out the latest pre-print from the lab! Great work led by Slater Clay @SlaterC_ Oral acetoacetate reduces tumor burden in colon cancer models by forming an MR1 ligand that boosts anti-tumor MAIT cells. biorxiv.org/content/10.1101/…
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Our 1st Roadmap asking why do patients with cancer die? is now FREE to access for 1 month starting today! The precise causes of mortality in patients with cancer remains poorly understood & this piece starts to highlight areas of unmet need for targeting go.nature.com/3RDKlao
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Nicholas Fabiano, MD
@NTFabiano15 Jul 2024
The antidepressant effects of exercise. 🧵1/8
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Cancer Cell@Cancer_Cell12 Jul 2024
Bacteria in metastatic sites: Unveiling hidden players in cancer progression dlvr.it/T9Vrt5
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Moffitt Laboratory@MoffittLab2 Jul 2024
So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of @AriSarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.1101/…) 1/12
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Nature Medicine
@NatureMedicine13 May 2024
⭐Research highlight: Enzymes derived from gut bacteria switch A and B blood types to Group O (‘universal’), a strategy that could help solve blood donor shortages in the future. @NatureMicrobiol nature.com/articles/d41591-0…
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A study in @NatureMicrobiol shows that enzymes found in the gut resident bacteria, Akkermansia muciniphila, can convert both known and previously not recognized antigens on human red blood cells to make group O blood. go.nature.com/3QLIPTh
This is figure 1, which shows the ABO blood group antigens on RBCs and mucins.

ALT This is figure 1, which shows the ABO blood group antigens on RBCs and mucins.

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Matthias Lutolf@TheLutolfLab25 Apr 2024
Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling rdcu.be/dFD2v. Let’s have a quick look!
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Very excited to share our latest work, out today in @ScienceMagazine, on the serendipitous finding that vitamin D ☀️ regulates the gut microbiome to promote cancer immunity🦠 science.org/doi/10.1126/scie… 🧵👇 @ReiseSousaLab @TheCrick
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NEW content online! Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications dlvr.it/T5Fz27
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Cancer Cell@Cancer_Cell5 Apr 2024
Online Now: Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer dlvr.it/T56TmN
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Exciting study!!
Belkaid Lab@BelkaidLab5 Apr 2024
Happy to share our recent work led by postdoc @LiangChi281017 published today in @Science 🥳Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis.👇 science.org/doi/10.1126/scie…

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis

Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here,...

science.org
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Belkaid Lab@BelkaidLab5 Apr 2024
Happy to share our recent work led by postdoc @LiangChi281017 published today in @Science 🥳Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis.👇 science.org/doi/10.1126/scie…

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis

Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here,...

science.org
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New study: a bacteria that normally lives in the mouth was found in 50% of colon cancers. This is consistent with prior research on the interactions between the microbiome and colon cancer, which is rising among young people. nature.com/articles/s41586-0….

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

Nature - A study reveals that Fusobacterium nucleatum subspecies animalis is bifurcated into two distinct clades, and shows that only one of these dominates the colorectal cancer niche, probably...

nature.com
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☕️In this issue: @OphirKlein, @RKZwick & co examine the mouse & human #SmallIntestine and find that both comprise 5 domains of #NutrientAbsorption and 3 regional #StemCell populations. 👉🏾rdcu.be/dyS3s nature.com/articles/s41556-0…
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Omer Yilmaz
@ohyilmaz28 Feb 2024
nature.com/articles/s41586-0… Great teamwork from amazing Post doctoral fellow Nori Goto and our wonderful DFCI collaborator @JudithAgudo1 showing how the earliest premalignant intestinal stem cell evade immune detection. @MITBiology @kochinstitute @DanaFarber @BIDMCpath @MGHPathology @DrMartyTaylor
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Mikala Egeblad@megeblad22 Feb 2024
We found that chronic stress increases metastasis in mice. The neutrophils are at the helm (again!). Link to our report in @Cancer_Cell: authors.elsevier.com/a/1ieO0…
Cold Spring Harbor Laboratory
@CSHL22 Feb 2024
Chronic stress increases cancer metastasis risk – but how? CSHL Cancer Center researchers may have the answer! #CancerResearch cshl.edu/chronic-stress-spre…

Chronic stress spreads cancer … here’s how | Cold Spring Harbor Laboratory

Stress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has...

cshl.edu
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New content online: Ultra-processed foods and food additives in gut health and disease dlvr.it/T36zLv
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The conneXion between sex and immune responses dlvr.it/T33mky
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The gut microbiota can shape the CRC tumor microenvironment in many different ways! 🦠 Have a look at our latest review published now in @AnnualReviews. Very fun to write with @NatashAndreeva, our super smart PhD student! ✨@HarvardIID @broadinstitute @EMBOFellows
Garrett Lab@theGarrettLab15 Feb 2024
Curious about how the gut microbiota drives colorectal cancer & modulates the immune response?🦠Check out our latest review in @AnnualReviews! Kudos to @JenTekle & @Natalia74086262 for their outstanding work 🌟@HarvardChanSPH @broadinstitute @CancerGrand doi.org/10.1146/annurev-phys…
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