@MoffittLab
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A research group passionate about developing genomic microscopy methods to illuminate microbe-host interactions. @BostonChildrens @harvardmed | moffittlab.bsky
Boston, MA
Joined April 2023
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Genome Research has just announced an exciting call for spatial 'omics related papers! I am thrilled to be co-editing this special issue with Jian Ma (@jmuiuc) and Christina Leslie!
Interested in cutting-edge work in both the development and application of techniques to better understand gene regulation from a systems perspective? Abstract submissions are still open for this CSHL meeting: meetings.cshl.edu/meetings.a…
Excited to share our new work from Rosalind Xu, where we used MERFISH to build a single-cell spatial transcriptomic atlas of the mouse gut—and to explore host-microbiome interactions in situ! biorxiv.org/content/10.1101/… 1/
Remarkably, many aspects of the gut were largely unchanged! Nonetheless, we observed profound shifts in immune cell abundance and distribution—highlighting the central role of the microbiota in shaping and educating the immune system. 11/
Yesterday our first grad student -- DR. Rosalind Xu -- had her official PhD hooding ceremony in @HarvardCCB! A massive congratulations to her and all of the other freshly minted PhDs!
Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: biorxiv.org/content/10.1101/… 1/9
To our surprise, we found that some plasma cell clones form patches of co-occurring clones along the gut, suggesting, perhaps, that there is local production of IgA specific to a subset of the microbiome! 8/9
