@JchenLab

Phages, bacteria, and pathogenicity islands. @NUSMedicine.

 Singapore
Joined October 2018
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  • Following332
  • Followers688
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Pleased to share our latest study @NatureComms. We show that the host metabolites fumarate and itaconate impose selective pressure on Staphylococcus aureus, driving its adaptation via the enzyme FumC. Grateful to all who contributed to this work! nature.com/articles/s41467-0…

Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia

Nature Communications - This study reveals how the pathogen Staphylococcus aureus adapts to the lung microenvironment, rich in host metabolites fumarate and itaconate, by using a key enzyme, FumC,...

nature.com
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A new encyclopedic review, for plasmid lovers: academic.oup.com/nar/article… We (Mapi, Eduardo and I) hope you like it!

The extended mobility of plasmids

Abstract. Plasmids play key roles in the spreading of many traits, ranging from antibiotic resistance to varied secondary metabolism, from virulence to mut

academic.oup.com
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1/11 New #MRSA #Staph publication from Dr. Diane Boff a talented former postdoc co-mentored by the @TorresVJ_Lab and @DrShrutiNaik! science.org/doi/10.1126/scia…

Staphylococcus aureus LukMF′ targets neutrophils to promote skin and soft tissue infection

A natural rodent model of Staphylococcus aureus infection unearthed LukMF′ as a driver of skin and soft tissue infections.

science.org
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Happy to share our new preprint describing prophage encoded anti-phage defense system,TERi, that targets the terminase complex of invading phages to inhibit DNA packaging. The system also encode self immunity proteins that protect the prophage. biorxiv.org/content/biorxiv/…
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New mechanism of gene transfer! With @CostaT_Lab @CBRB_Imperial, cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE
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JChen Lab retweeted
Yuan@Yuanqiao100227 Jan 2025
We have a fully funded PhD scholarship for Aug 2025 intake. If you are interested in joining our research group, please check the admission requirement on the website and contact us. ntu.edu.sg/education/graduat…

Doctor of Philosophy | Chemistry

A rigorous PhD programme in Chemistry combining advanced coursework with research experience. #2 in Asia and #8 in the world for Chemistry, according to the 2025 QS World University Rankings by...

ntu.edu.sg
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PhD projects at University of Leicester Including three phage projects .... With @MarthaClokie , and me. Including an iCASE project with Dr Abhinav Koyamangalath Vadakkepat , using cryoEM le.ac.uk/study/research-degr…

BBSRC Midlands Integrative Biosciences Training Partnership | Postgraduate research | University of...

The Midlands Integrative Biosciences (Doctoral) Training Partnership (MIBTP) funded by the BBSRC Doctoral Landscape Award is a partnership between University of Warwick, University of Birmingham,...

le.ac.uk
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Pls share: Microbiology faculty position available at Texas A&M University.
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Our paper is finally out at Nature Microbiology. A team effort discovering Tailocin cell factories. Listeria monocytogenes bacteria produce and store ~6000 tailocins per cell in a remarkable way. nature.com/articles/s41564-0…
Raz Zarivach@zarivach21 Sep 2024
Happy to be part of this crazy team.
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1/7 Happy to share a new publication from the team spearheaded by @Keenan__Lacey published today in @ScienceAdvances. This project was started at @nyugrossman and was completed @StJudeResearch by @APickrum and A. Castellaw. science.org/doi/10.1126/scia…

Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens

Dietary and water restriction increases susceptibility to antimicrobial resistant pathogens by disrupting macrophage function.

science.org
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Our T6SS paper on TssA is now available @NatureComms A publication marathon but so happy to see this accepted on my birthday TssA is an intriguing protein providing specificity and fine tuning in T6SS assembly and firing. Thank you so much for your brilliant work Selina et al
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Thank you to our excellent reviewers and Editor for helping us to improve significantly this review with their very useful comments!
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Just missing April fool's, here is something that is no laughing matter: nature.com/articles/s41564-0… In @NatureMicrobiol, we describe how a prophage avoids autoimmunity from its own defence systems
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Led by @jakob_tr and @quiles_nuria, with @lasa_lab, we show that prophages utilise noncontiguous operons to balance immunity and autoimmunity. Our results underscore the essential fine regulation of these processes for prophages' life cycle development. nature.com/articles/s41564-0…

Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life...

Nature Microbiology - Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.

nature.com
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PhD student opening! We are collaborating with the team of David Johnson @EawagResearch to understand E. faecalis polymicrobial community assembly, interactions, and consequences for AMR and infection. Check out David's lab and work here: tinyurl.com/yrz3e2ae.
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Here's a little venture of mine🚀! We've launched Scientifica Media, a scientific communication company that helps connect writers with relevant scientific backgrounds to deep tech companies! Website: scientifica.media Email: [email protected]
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JChen Lab retweeted
YHGanLab@YHGanLab22 Jan 2024
Here's our latest endeavour into #AI-driven identification of synergistic drug combinations (out of half a million possible ones!) with broad spectrum activity against #MDR bacteria Read more: onlinelibrary.wiley.com/doi/….
YunnHwen Gan@yunnhwen19 Jan 2024
A great group effort in identifying broad spectrum,new drug combinations against #MDR bacteria using #AI platform! onlinelibrary.wiley.com/doi/…. @thedeanh @YHGanLab @echow310 @OonTek1
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A great group effort in identifying broad spectrum,new drug combinations against #MDR bacteria using #AI platform! onlinelibrary.wiley.com/doi/…. @thedeanh @YHGanLab @echow310 @OonTek1
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Well, I've been laid off from The Messenger. If you're looking for an experienced reporter eager to take on complicated stories that explore the intersections of science, health and policy, please get in touch!
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