Phages, bacteria, and pathogenicity islands. @NUSMedicine.
Singapore
Joined October 2018
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JChen Lab retweeted
Pleased to share our latest study @NatureComms. We show that the host metabolites fumarate and itaconate impose selective pressure on Staphylococcus aureus, driving its adaptation via the enzyme FumC. Grateful to all who contributed to this work!
nature.com/articles/s41467-0…
JChen Lab retweeted
A new encyclopedic review, for plasmid lovers:
academic.oup.com/nar/article…
We (Mapi, Eduardo and I) hope you like it!
JChen Lab retweeted
1/11 New #MRSA #Staph publication from Dr. Diane Boff a talented former postdoc co-mentored by the @TorresVJ_Lab and @DrShrutiNaik!
science.org/doi/10.1126/scia…
JChen Lab retweeted
Happy to share our new preprint describing prophage encoded anti-phage defense system,TERi, that targets the terminase complex of invading phages to inhibit DNA packaging. The system also encode self immunity proteins that protect the prophage.
biorxiv.org/content/biorxiv/…
JChen Lab retweeted
New mechanism of gene transfer! With @CostaT_Lab @CBRB_Imperial, cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE
JChen Lab retweeted
We have a fully funded PhD scholarship for Aug 2025 intake.
If you are interested in joining our research group, please check the admission requirement on the website and contact us.
ntu.edu.sg/education/graduat…
JChen Lab retweeted
PhD projects at University of Leicester
Including three phage projects ....
With @MarthaClokie , and me. Including an iCASE project with Dr Abhinav Koyamangalath Vadakkepat , using cryoEM
le.ac.uk/study/research-degr…
JChen Lab retweeted
Our paper is finally out at Nature Microbiology. A team effort discovering Tailocin cell factories. Listeria monocytogenes bacteria produce and store ~6000 tailocins per cell in a remarkable way.
nature.com/articles/s41564-0…
We had a similar problem. For us it was was Qiagen minipreps. Some people don’t angle the lids of the tubes correctly in the elution step. The lids break off and they cause damage before being pulverized to dust.
JChen Lab retweeted
1/7 Happy to share a new publication from the team spearheaded by @Keenan__Lacey published today in @ScienceAdvances. This project was started at @nyugrossman and was completed @StJudeResearch by @APickrum and A. Castellaw. science.org/doi/10.1126/scia…
JChen Lab retweeted
Our T6SS paper on TssA is now available @NatureComms
A publication marathon but so happy to see this accepted on my birthday
TssA is an intriguing protein providing specificity and fine tuning in T6SS assembly and firing.
Thank you so much for your brilliant work Selina et al
JChen Lab retweeted
Thank you to our excellent reviewers and Editor for helping us to improve significantly this review with their very useful comments!
JChen Lab retweeted
Just missing April fool's, here is something that is no laughing matter:
nature.com/articles/s41564-0…
In @NatureMicrobiol, we describe how a prophage avoids autoimmunity from its own defence systems