
Walter-Benjamin PostDoc Fellow👨🏼🔬 RNA-Biologist 🧫 Cancer Researcher🧬 at Filbin Lab | @DanaFarber | @HarvardMed | @BroadInstitute
Boston, MA, USA
Joined July 2020
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- Following623
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Jacob retweeted
Join us for the 2nd ETA-ATA Trainee Joint Online Meeting
🗓️Tuesday, May 21st
8am PT🏄♀️
11am EST🦃
5pm CET🇪🇺
Connect with your peers in thyroidology!
@F_ThurstonDrake @AmThyroidAssn @ETA_Thyroid @LATS_Society @britishthyroid
Free event, register here: rb.gy/q9sgzo
Jacob retweeted
Published today! 📰
@NatureMedicine
One of the first #cancer vaccines💉that target #KRAS. Not just G12C.
👇🏾The 2-peptide was G12D & R.
The 7-Peptide/Elicio targets
D
R
V
S
A
C
G13
➕
NRAS
Implications for so many patients!
Open now.
Cheers!
@OncoAlert
nature.com/articles/s41591-0…
Jacob retweeted
Finally out!
We found that mRNAs are not uniformly distributed across the cytoplasm.
mRNA architecture is the strongest determinant for localization.
Subcytoplasmic location of translation controls protein output.
cell.com/molecular-cell/full…
Jacob retweeted
Rocket science is hard.
Designing systems capable of launching materials—including humans—into orbit and then smoothly landing back on terrestrial ground is one of the greatest feats of engineering we’ve achieved.
But surviving in space will be even harder.
In his brilliant 2020 keynote on the future of genetic engineering, Asimov CEO @alectricity made the following argument:
And space, the final frontier. Everyone talks about rocket science being the hard problem about outer space. But biology is the really hard thing about outer space. We need to able to manufacture food and therapeutics in the defined closed system of a space station. One day, we need to be able to terraform entire planets to be hospitable for life. We need to be able to engineer biomes.
These are biology problems, not rocket problems.
Today, in the Century of Biology, I explore the landscape of biotech-enabled sustainable space exploration.
Read here:
centuryofbio.com/p/colonizin…
Jacob retweeted
First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns go.nature.com/47ekkUM
Jacob retweeted
Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in @NatureCancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy.
@broadinstitute @sangerinstitute @getz_lab
Thread below 🧵
nature.com/articles/s43018-0…
Jacob retweeted
We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.07.06.5…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/
Jacob retweeted
Out today in @NatureGenet, our work utilizing single-cell multi-omics to define specific immune cell subsets that experience purifying selection against pathogenic mitochondrial DNA. nature.com/articles/s41588-0… Check out a thread about this work below: 1/22
Jacob retweeted
Registration is now open for the Berlin Summer Meeting 2023 - The MDC Celebrates 15 Years of BIMSB, 6-7 Sept, 2023:
bit.ly/bimsb2023
We are looking forward to a fantastic line-up showcasing exciting new developments in #systemsbiology
@MDC_Berlin
Jacob retweeted
Cracking the "black box” using human brain organoids, truly inspiring discoveries ahead of us! 🧫🧠🧬#brainorganoids #organoids #stemcells #future #development
Learn about @ArlottaLab and why studying brain #organoids has been compared to "cracking open a 'black box'" in this @HarvardMagazine feature article. harvardmagazine.com/2023/07/…
Jacob retweeted
Single-cell ATAC-seq finds active regulatory elements across cell types, but its resolution can be limited. What if we could identify when and where proteins bind to chromatin?
Introducing PRINT, a new single-cell footprinting tool from @JD_Buenrostro lab
biorxiv.org/content/10.1101/…
Jacob retweeted
I'm thrilled to share our new study reporting why DNA replication timing is important for the formation of oncogenic translocations, now published in @ScienceMagazine. In the Pavri lab, we explored oncogenic translocations in #lymphoma & #leukaemia 🧵👇 1/
doi.org/10.1126/science.abj5…
Jacob retweeted
Looking for protein chemists to join my lab @KidsCancerInst. If you are interested (more details) please DM. Exciting opportunity to develop tools to study RNA-protein interactions in cancer.
Jacob retweeted
If you are interested in our in vivo study of TERT promoter mutations, or if you just wanna chat about thyroid cancer genetics and biology, happy to meet you at our #AACR22 poster.
Section 10, Board 3, Poster #913
Starting now, will be around until 12.30 (with coffee breaks!)
Jacob retweeted
There is still time to apply for this position in my lab. Please do reach out! RTs appreciated!
We have an open position for a Research Assistant to join my lab in May/June 2022.
See description and apply via the link below 👇
partners.taleo.net/careersec…
Prospective applicants: feel free to reach out for informal inquiries
Rest: please spread the word - appreciate RTs!
Jacob retweeted
We are hiring!! Searching for a motivated wet-lab staff scientist and computational scientist to lead cutting edge #SingleCellMultiomics and #SpatialTranscriptomics in childhood brain tumors, as well as #TumorCellShapeShifting projects. Please RT and DM if interested. 🥳
Jacob retweeted
We're thrilled to announce a new plasmidsaurus dropbox at @harvardmed in Longwood, Boston, in the lobby at the Blackfan Circle entrance of the New Research Building, 77 Ave. Louis Pasteur. Shipping 1pm on Thursdays to start, more days to come if you all use it...
Jacob retweeted
We have an open position for a Research Assistant to join my lab in May/June 2022.
See description and apply via the link below 👇
partners.taleo.net/careersec…
Prospective applicants: feel free to reach out for informal inquiries
Rest: please spread the word - appreciate RTs!
Jacob retweeted
Our work on single-cell ribosome profiling is out! Huge congrats to @mvanins who was brave enough to embark on this pretty crazy experiment that turned out to work beautifully. Thank you @jervdberg, Amanda Andersson-Rolf and @HansClevers. Check it out: nature.com/articles/s41586-0…
Jacob retweeted
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells (Brien et al.) go.nature.com/3ByinmJ

























