Walter-Benjamin PostDoc Fellow👨🏼‍🔬 RNA-Biologist 🧫 Cancer Researcher🧬 at Filbin Lab | @DanaFarber | @HarvardMed | @BroadInstitute

Boston, MA, USA
Joined July 2020
Join us for the 2nd ETA-ATA Trainee Joint Online Meeting 🗓️Tuesday, May 21st 8am PT🏄‍♀️ 11am EST🦃 5pm CET🇪🇺 Connect with your peers in thyroidology! @F_ThurstonDrake @AmThyroidAssn @ETA_Thyroid @LATS_Society @britishthyroid Free event, register here: rb.gy/q9sgzo
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What a great manuscript from Jakob Trendel @kusterlab ! After XRNAX (loved it!) XDNAX helps enriching for DNA-associated proteins! Top quality paper
...and another new Preprint coming right on its heels! This time by Jakob Trendel and colleagues. doi.org/10.1101/2024.04.04.5…
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Landmark paper alert! Women develop more autoimmune disease -> The proteins associated with the long non-coding RNA Xist (silence the second X chromosome in women) comprise numerous autoantigenic components as important driver of sex-biased autoimmunity cell.com/cell/fulltext/S0092…
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Promoter, Enhancer, Super-Enhancer- and here comes the Coordinator! Exciting read! Out in Cell cell.com/cell/fulltext/S0092…
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Published today! 📰 @NatureMedicine One of the first #cancer vaccines💉that target #KRAS. Not just G12C. 👇🏾The 2-peptide was G12D & R. The 7-Peptide/Elicio targets D R V S A C G13 ➕ NRAS Implications for so many patients! Open now. Cheers! @OncoAlert nature.com/articles/s41591-0…
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Finally out! We found that mRNAs are not uniformly distributed across the cytoplasm. mRNA architecture is the strongest determinant for localization. Subcytoplasmic location of translation controls protein output. cell.com/molecular-cell/full…
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Rocket science is hard. Designing systems capable of launching materials—including humans—into orbit and then smoothly landing back on terrestrial ground is one of the greatest feats of engineering we’ve achieved. But surviving in space will be even harder. In his brilliant 2020 keynote on the future of genetic engineering, Asimov CEO @alectricity made the following argument: And space, the final frontier. Everyone talks about rocket science being the hard problem about outer space. But biology is the really hard thing about outer space. We need to able to manufacture food and therapeutics in the defined closed system of a space station. One day, we need to be able to terraform entire planets to be hospitable for life. We need to be able to engineer biomes. These are biology problems, not rocket problems. Today, in the Century of Biology, I explore the landscape of biotech-enabled sustainable space exploration. Read here: centuryofbio.com/p/colonizin…
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Jacob retweeted
First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns go.nature.com/47ekkUM
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Finally out! 👨🏼‍🔬 We describe non-telomeric effects of Tert upregulation in thyroid cancers in mice with the very first model containing a Tert promoter mutation. What a journey for this story and Iñigo. 🍻
1/ Our manuscript "Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects" is now out at @MCR_AACR 👇👇👇 Here comes a thread... aacrjournals.org/mcr/article…
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We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.07.06.5…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/
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Out today in @NatureGenet, our work utilizing single-cell multi-omics to define specific immune cell subsets that experience purifying selection against pathogenic mitochondrial DNA. nature.com/articles/s41588-0… Check out a thread about this work below: 1/22
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Registration is now open for the Berlin Summer Meeting 2023 - The MDC Celebrates 15 Years of BIMSB, 6-7 Sept, 2023: bit.ly/bimsb2023 We are looking forward to a fantastic line-up showcasing exciting new developments in #systemsbiology @MDC_Berlin
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Cracking the "black box” using human brain organoids, truly inspiring discoveries ahead of us! 🧫🧠🧬#brainorganoids #organoids #stemcells #future #development
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There is an open position available in the Landa lab! Collaborate with clinicians/researchers in the Boston/Harvard environment! Help advancing the knowledge on advanced thyroid cancers and join a leading lab in the field. #thyroid #brighamandwomens #harvardmed #boston
We have an open position for a Research Assistant to join my lab, available immediately. Please see details in the link below: drive.google.com/file/d/16KE… Prospective applicants: please reach out to me directly! Rest: please retweet & spread the word in your networks
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Single-cell ATAC-seq finds active regulatory elements across cell types, but its resolution can be limited. What if we could identify when and where proteins bind to chromatin? Introducing PRINT, a new single-cell footprinting tool from @JD_Buenrostro lab biorxiv.org/content/10.1101/…
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I'm thrilled to share our new study reporting why DNA replication timing is important for the formation of oncogenic translocations, now published in @ScienceMagazine. In the Pavri lab, we explored oncogenic translocations in #lymphoma & #leukaemia 🧵👇 1/ doi.org/10.1126/science.abj5…
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An extremely interesting case report about thyroid cancer with platinum signature occurring 8 years after previous platinum-based chemotherapy of ovarian cancer☝🏻Nice job Theodora and the other authors ascopubs.org/doi/figure/10.1…
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Join our lab in Boston! You‘ll have the chance to experience great science, collaborations and Iñigo as the best PI.👨🏼‍🔬 #thyroidcancer #research #sciencejobs #boston
We are looking for a postdoctoral fellow. Full details here 👇👇👇 drive.google.com/file/d/1gy_… If you are interested, please reach out! And, if you can, please spread the word!
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