
Walter-Benjamin PostDoc Fellow👨🏼🔬 RNA-Biologist 🧫 Cancer Researcher🧬 at Filbin Lab | @DanaFarber | @HarvardMed | @BroadInstitute
Boston, MA, USA
Joined July 2020
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Out now in @CellRepMed ! 🧠🔬
1/✨New study out in @CellRepMed ! - LaBelle & Haase et al. 2025
🧠🔬 Let's dive in to our latest collaborative work with @MariellaFilbin & Kai Wucherpfennig!
cell.com/cell-reports-medici…
Jacob retweeted
Join us for the 2nd ETA-ATA Trainee Joint Online Meeting
🗓️Tuesday, May 21st
8am PT🏄♀️
11am EST🦃
5pm CET🇪🇺
Connect with your peers in thyroidology!
@F_ThurstonDrake @AmThyroidAssn @ETA_Thyroid @LATS_Society @britishthyroid
Free event, register here: rb.gy/q9sgzo
What a great manuscript from Jakob Trendel @kusterlab ! After XRNAX (loved it!) XDNAX helps enriching for DNA-associated proteins! Top quality paper
...and another new Preprint coming right on its heels! This time by Jakob Trendel and colleagues. doi.org/10.1101/2024.04.04.5…
Landmark paper alert!
Women develop more autoimmune disease -> The proteins associated with the long non-coding RNA Xist (silence the second X chromosome in women) comprise numerous autoantigenic components as important driver of sex-biased autoimmunity
cell.com/cell/fulltext/S0092…
Promoter, Enhancer, Super-Enhancer- and here comes the Coordinator! Exciting read! Out in Cell cell.com/cell/fulltext/S0092…
Jacob retweeted
Published today! 📰
@NatureMedicine
One of the first #cancer vaccines💉that target #KRAS. Not just G12C.
👇🏾The 2-peptide was G12D & R.
The 7-Peptide/Elicio targets
D
R
V
S
A
C
G13
➕
NRAS
Implications for so many patients!
Open now.
Cheers!
@OncoAlert
nature.com/articles/s41591-0…
Jacob retweeted
Finally out!
We found that mRNAs are not uniformly distributed across the cytoplasm.
mRNA architecture is the strongest determinant for localization.
Subcytoplasmic location of translation controls protein output.
cell.com/molecular-cell/full…
Jacob retweeted
Rocket science is hard.
Designing systems capable of launching materials—including humans—into orbit and then smoothly landing back on terrestrial ground is one of the greatest feats of engineering we’ve achieved.
But surviving in space will be even harder.
In his brilliant 2020 keynote on the future of genetic engineering, Asimov CEO @alectricity made the following argument:
And space, the final frontier. Everyone talks about rocket science being the hard problem about outer space. But biology is the really hard thing about outer space. We need to able to manufacture food and therapeutics in the defined closed system of a space station. One day, we need to be able to terraform entire planets to be hospitable for life. We need to be able to engineer biomes.
These are biology problems, not rocket problems.
Today, in the Century of Biology, I explore the landscape of biotech-enabled sustainable space exploration.
Read here:
centuryofbio.com/p/colonizin…
Jacob retweeted
First trial of ‘base editing’ in humans lowers cholesterol — but raises safety concerns go.nature.com/47ekkUM
Finally out! 👨🏼🔬
We describe non-telomeric effects of Tert upregulation in thyroid cancers in mice with the very first model containing a Tert promoter mutation. What a journey for this story and Iñigo.
🍻
1/ Our manuscript "Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects" is now out at @MCR_AACR 👇👇👇
Here comes a thread...
aacrjournals.org/mcr/article…
Jacob retweeted
Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in @NatureCancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy.
@broadinstitute @sangerinstitute @getz_lab
Thread below 🧵
nature.com/articles/s43018-0…
Jacob retweeted
We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.07.06.5…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/
Jacob retweeted
Out today in @NatureGenet, our work utilizing single-cell multi-omics to define specific immune cell subsets that experience purifying selection against pathogenic mitochondrial DNA. nature.com/articles/s41588-0… Check out a thread about this work below: 1/22
Jacob retweeted
Registration is now open for the Berlin Summer Meeting 2023 - The MDC Celebrates 15 Years of BIMSB, 6-7 Sept, 2023:
bit.ly/bimsb2023
We are looking forward to a fantastic line-up showcasing exciting new developments in #systemsbiology
@MDC_Berlin
Jacob retweeted
Cracking the "black box” using human brain organoids, truly inspiring discoveries ahead of us! 🧫🧠🧬#brainorganoids #organoids #stemcells #future #development
Learn about @ArlottaLab and why studying brain #organoids has been compared to "cracking open a 'black box'" in this @HarvardMagazine feature article. harvardmagazine.com/2023/07/…
There is an open position available in the Landa lab! Collaborate with clinicians/researchers in the Boston/Harvard environment! Help advancing the knowledge on advanced thyroid cancers and join a leading lab in the field.
#thyroid #brighamandwomens #harvardmed #boston
We have an open position for a Research Assistant to join my lab, available immediately.
Please see details in the link below: drive.google.com/file/d/16KE…
Prospective applicants: please reach out to me directly!
Rest: please retweet & spread the word in your networks
Jacob retweeted
Single-cell ATAC-seq finds active regulatory elements across cell types, but its resolution can be limited. What if we could identify when and where proteins bind to chromatin?
Introducing PRINT, a new single-cell footprinting tool from @JD_Buenrostro lab
biorxiv.org/content/10.1101/…
Jacob retweeted
I'm thrilled to share our new study reporting why DNA replication timing is important for the formation of oncogenic translocations, now published in @ScienceMagazine. In the Pavri lab, we explored oncogenic translocations in #lymphoma & #leukaemia 🧵👇 1/
doi.org/10.1126/science.abj5…
An extremely interesting case report about thyroid cancer with platinum signature occurring 8 years after previous platinum-based chemotherapy of ovarian cancer☝🏻Nice job Theodora and the other authors
ascopubs.org/doi/figure/10.1…
Join our lab in Boston! You‘ll have the chance to experience great science, collaborations and Iñigo as the best PI.👨🏼🔬 #thyroidcancer #research #sciencejobs #boston
We are looking for a postdoctoral fellow.
Full details here 👇👇👇
drive.google.com/file/d/1gy_…
If you are interested, please reach out! And, if you can, please spread the word!




















