Harrison Society PGY1 at @VUMC_MedPSTP. @UABMSTP alum, dog dad, @SpursOfficial supporter, and aspiring ID physician-scientist.
Birmingham, AL
Joined September 2011
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Jacob Files retweeted
Super exciting to see our work on immune responses to acute COVID-19 in people with HIV published. Grateful for the endless support from @NerdmannID @JacobFiles93
Impact of Chronic HIV Infection on Acute Immune Responses to SARS-CoV-2:
journals.lww.com/jaids/abstr…
Looking forward to exploring different programs and meeting my fellow applicants on the interview trail!
Hello! My name is Jake Files and I’m applying to internal medicine with an interest in combined research residency programs and infectious diseases! My scientific interests include all host-pathogen interactions and specifically viral immunology.
#Match2024 #Medtwitter
Jacob Files retweeted
#Registration, #abstract submissions, and undergraduate travel award applications are open for #SEMSS2023! Please to go our website southeasternmdphd.org/ for more information on how to register and submit your work!
#physicianscientist #scienceinmedicine #travelaward
Jacob Files retweeted
3 Oct 29, 2020, Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection
T cell activation/exhaustion markers remaining elevated in hospitalized and nonhospitalized. B cells had similar pattern of activation/exhaustion,
jci.org/articles/view/140491
Jacob Files retweeted
Immune dysfunction after Covid19.
We've known since 2020.
We do not know if it is progressive, but w reinfections pretty high & viral persistence occurring it does not matter.
A thread from my threads - the top 12 papers showing clear immune dysregulation in chronological order!
Interesting article about this below. Seems that they want you to discuss multiple hobbies/interests under the "Selected Experiences" section with a 750 word limit. Thoughts about whether this would be better than including it in the personal statement? medpagetoday.com/special-rep…
Thanks goes to @UABMSTP for allowing us to attend and @A_P_S_A for putting on such a great conference! As always, I appreciate @NerdmannID and @OASkye for the support and the exciting science that I was able to present!
Finished Step 2 and my MS3 clinical year this past week and was able to celebrate by attending @JointMeeting! Was able to attend some amazing talks, network with program directors, and even try some deep-dish pizza!
Jacob Files retweeted
Interested in knowing how immune activation & antigen persistence impact both acute #COVID19 & #LongCovid ? Check out our recently published review paper! @JacobFiles93 @NerdmannID ncbi.nlm.nih.gov/pmc/article…
Overall, these results suggest that vaccine-encoded adapted epitopes dampen CD4+ T-cell responses and impact HIV-specific antibody production. We believe a future "fully non-adapted" HIV vaccine may provide optimal B-cell help for improved HIV-specific antibody production.
5/5
Additionally, while NAE-specific CD4+ T-cell responses correlated with HIV-specific antibodies (IgG Env Ab) in one efficacy trial, this was not found to be the case with CD4 + T-cell responses to AE.
4/5
By using samples from previous HIV vaccine trials, our study shows that certain vaccine epitopes with evidence of immune escape (termed adapted epitopes or AE), elicit weaker CD4+ T-cell responses when compared to non-adapted epitopes (NAE).
3/5
Some background: The field has yet to create an effective HIV vaccine. Prior HIV vaccine trials have suggested that CD4+ T cell responses help to generate improved HIV-specific antibody responses. However, we believe that these CD4+ T cell responses can be further optimized.
2/5
The last paper from my PhD dissertation was recently published in the Journal of Virology!
As always, much thanks to @goepfert_paul for his mentorship and for the rest of the Goepfert lab!
journals.asm.org/doi/10.1128…
A quick thread summarizing our findings:
1/5
Started my MS3 clinical rotations a few months ago. Loving it! I also just resubmitted a manuscript from my PhD thesis project after receiving reviewer comments.
Seeing patients during the week, submitting papers on the weekend... I ALMOST feel like a physician-scientist! 😂
Highly recommend @tpwky for any and all interested in ID. Goes over the history, biology, and epidemiology of different pathogens.