@JacobFiles93

Harrison Society PGY1 at @VUMC_MedPSTP. @UABMSTP alum, dog dad, @SpursOfficial supporter, and aspiring ID physician-scientist.

 Birmingham, AL
Joined September 2011
  • Tweets624
  • Following268
  • Followers217
28Media
Hello! My name is Jake Files and I’m applying to internal medicine with an interest in combined research residency programs and infectious diseases! My scientific interests include all host-pathogen interactions and specifically viral immunology. #Match2024 #Medtwitter
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Jacob Files retweeted
Skye Opsteen@OASkye25 Feb 2024
Super exciting to see our work on immune responses to acute COVID-19 in people with HIV published. Grateful for the endless support from @NerdmannID @JacobFiles93 Impact of Chronic HIV Infection on Acute Immune Responses to SARS-CoV-2: journals.lww.com/jaids/abstr…

Impact of Chronic HIV Infection on Acute Immune... : JAIDS Journal of Acquired Immune Deficiency...

Abstract:There is mounting evidence that HIV infection is a risk factor for severe presentations of COVID-19. We hypothesized that the persistent...

ovid.com
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Looking forward to exploring different programs and meeting my fellow applicants on the interview trail!
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Jacob Files retweeted
SEMSS@SEmdphd13 Jul 2023
#Registration, #abstract submissions, and undergraduate travel award applications are open for #SEMSS2023! Please to go our website southeasternmdphd.org/ for more information on how to register and submit your work! #physicianscientist #scienceinmedicine #travelaward
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3 Oct 29, 2020, Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection T cell activation/exhaustion markers remaining elevated in hospitalized and nonhospitalized. B cells had similar pattern of activation/exhaustion, jci.org/articles/view/140491
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Immune dysfunction after Covid19. We've known since 2020. We do not know if it is progressive, but w reinfections pretty high & viral persistence occurring it does not matter. A thread from my threads - the top 12 papers showing clear immune dysregulation in chronological order!
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Finished Step 2 and my MS3 clinical year this past week and was able to celebrate by attending @JointMeeting! Was able to attend some amazing talks, network with program directors, and even try some deep-dish pizza!
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Thanks goes to @UABMSTP for allowing us to attend and @A_P_S_A for putting on such a great conference! As always, I appreciate @NerdmannID and @OASkye for the support and the exciting science that I was able to present!
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Jacob Files retweeted
Skye Opsteen@OASkye13 Mar 2023
Interested in knowing how immune activation & antigen persistence impact both acute #COVID19 & #LongCovid ? Check out our recently published review paper! @JacobFiles93 @NerdmannID ncbi.nlm.nih.gov/pmc/article…
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The last paper from my PhD dissertation was recently published in the Journal of Virology! As always, much thanks to @goepfert_paul for his mentorship and for the rest of the Goepfert lab! journals.asm.org/doi/10.1128… A quick thread summarizing our findings: 1/5

HLA-II-Associated HIV-1 Adaptation Decreases CD4+ T-Cell Responses in HIV-1 Vaccine Recipients |...

Despite decades of research, an effective HIV-1 vaccine remains elusive. Vaccine strategies leading to the generation of broadly neutralizing antibodies are likely needed to provide the best opport...

journals.asm.org
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Additionally, while NAE-specific CD4+ T-cell responses correlated with HIV-specific antibodies (IgG Env Ab) in one efficacy trial, this was not found to be the case with CD4 + T-cell responses to AE. 4/5
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Overall, these results suggest that vaccine-encoded adapted epitopes dampen CD4+ T-cell responses and impact HIV-specific antibody production. We believe a future "fully non-adapted" HIV vaccine may provide optimal B-cell help for improved HIV-specific antibody production. 5/5
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Started my MS3 clinical rotations a few months ago. Loving it! I also just resubmitted a manuscript from my PhD thesis project after receiving reviewer comments. Seeing patients during the week, submitting papers on the weekend... I ALMOST feel like a physician-scientist! 😂
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PHD: Pretty Happy to be Done! 2 weeks ago, I successfully defended my PhD dissertation. While it feels great to be done, I am also sad to be leaving. I have greatly enjoyed my time in the lab with @goepfert_paul and many others. 1/4
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...and a sunset on a lake! Why choose the lakes or the mountains when you can choose both! Gotta love North Carolina. 3/4
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Starting the clinical phase of my MD training next week! Equally nervous and excited! Will be nice to have a direct role in patient care and to learn about all of medicine! 4/4
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Jacob Files retweeted
UAB MSTP@UABMSTP13 Apr 2022
Congrats to soon-to-be Dr. Jake Files (GS-4, Immunology), who'll be defending his dissertation this afternoon at 4 pm CST. The defense will be held in BBRB 170, or you can attend via Zoom (Meeting ID: 859 1612 3434).
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