@JackrelLab

Official student-run #ScienceTwitter of the Jackrel Lab at WashU/STL. Studying the biochemistry of protein misfolding, chaperones, & disaggregases

 St. Louis, MO
sites.wustl.edu/jackrel
Joined July 2018
  • Tweets94
  • Following140
  • Followers307
25Media
We are excited to share our paper on Matrin-3 phase separation that is out now!
Molecular Cell@MolecularCell22 Sep 2025
Online Now: Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations dlvr.it/TNDLRP
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Jackrel Lab Members retweeted
Jai Rudra he/him@JaiRudra416 Sep 2024
Grateful for a 5-yr R01 award from the National Institute on Aging for developing vaccines against neurodegenerative diseases. Thanks to collaborations with @JackrelLab and support from @WashUBME @WashUengineers
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Interesting: New paper from @JackrelLab & colleagues reports PDZ serine protease HTRA1 disaggregates #Parkinsons-associated α-synuclein amyloid fibrils & converts them into non-toxic/seeding incompetent species; Future = small molecule HTRA1 modulators nature.com/articles/s41467-0…
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📢We are excited to share that our paper on HTRA1 remodeling of alpha-synuclein is available now online with @NatureComms! Check out our main findings below 👇
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Big shout out 🗣️ to the team that made it all possible: Sheng Chen, @AnuradhikaP, Braxton Bell, Joey Fritsche, Hector Palacios, Maurie Balch, @MacySprunger, @matthewkhoward, Jeremy Ryan, Jessica Haines, @gjpattij, @GusDavisLab, & Meredith Jackrel!
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Check out the paper now to get all the juicy🧃details! nature.com/articles/s41467-0…
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So happy for and proud of our favorite boss Dr. Jackrel! Newest tenured prof in @WashUChem!
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Yesterday Sheng (Andy) Chen defended his dissertation like a star ⭐️ We are proud of all he has accomplished during his graduate studies! Congrats Dr. Chen!
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Yesterday we celebrated @MacySprunger's dissertation defense! 🎉She is the first graduate student to defend from the lab and we are very proud of all she has accomplished during her graduate studies!🧬
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It is the first look at one of our big projects in the lab! We have been investigating how human serine protease HTRA1 can prevent and disaggregate alpha-synuclein amyloid! You can check out the preprint now 👇👇researchsquare.com/article/r…

HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

Parkinson disease (PD) is closely linked to the misfolding and accumulation of α-synuclein (α-syn) into Lewy bodies. HtrA1 is a PDZ serine protease that degrades fibrillar tau, which is associated...

researchsquare.com
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@SHENGCH86713022 @AnuradhikaP @BalchMaurie @MacySprunger @matthewkhoward @gjpattij @GusDavisLab
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Our collabration with @JaiRudra4 is out now! See how the amphipathic self-assembling cross-β peptide KFE8 compares with α-syn and TDP-43, how it is cleared by cells, and how it performs as a vaccine backbone! @PareshShrimali6 sciencedirect.com/science/ar…
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