@JJeffet

PhD student @TelAvivUni, Physics, Optics, single-molecule, Epigenetics.

 Tel Aviv
Joined February 2020
  • Tweets49
  • Following162
  • Followers73
16Media
Awesome work! Very elegant way to get all the info in a single frame. Love it!
Lucien Weiss@LucienWeissLab23 Jul 2024
Woohoo! Localization in 4D (x, y, z, λ) at video framerates - "Vortex light field microscopy: 3D spectral single-molecule imaging with a twist" Thanks, @BoyaZhang4, @koholleran! @samofmidworld, C. Zhu, M.O. Lens,@LisaMariaN91,@Ruby_Peters_,@SteveTheChemist biorxiv.org/content/10.1101/…
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Yuval Ebenstein@hagenom2 Apr 2024
Just up on bioRxiv: Long-Read Structural and Epigenetic Profiling of a Kidney Tumor-matched Sample with Nanopore Sequencing and Optical Genome Mapping biorxiv.org/content/10.1101/…

Long-Read Structural and Epigenetic Profiling of a Kidney Tumor-matched Sample with Nanopore...

Carcinogenesis often involves significant alterations in the cancer genome architecture, marked by large structural and copy number variations (SVs and CNVs) that are difficult to capture with...

biorxiv.org
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Yoav Lahini@YLahini29 Sep 2023
Our latest research, just published in @NaturePhysics: slow relaxations and logarithmic aging occur via self-organized avalanches of local instabilities. Splendid work by @Yaniv_Friedman and Dor Shohat @ComplexLab_TAU @TelAvivUni nature.com/articles/s41567-0… rdcu.be/dngVA

Logarithmic aging via instability cascades in disordered systems

Nature Physics - Many complex systems relax slowly towards equilibrium after a perturbation, without ever reaching it. Experiments with crumpled sheets now show that these relaxations involve...

nature.com
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Yuval Ebenstein@hagenom8 May 2023
Check out our new single-molecule chromatin profiling method for ultralong DNA molecules with @bionanogenomics : Dam Assisted Fluorescent Tagging of Chromatin Accessibility (DAFCA) for Optical Genome Mapping in Nanochannel Arrays. pubs.acs.org/doi/full/10.102… Please RT
Open chromatin is labeled in the nucleus by a methyltransferase and a fluorescent cofactor. labeled high molecular weight DNA is extracted and stretched for imaging in nanochannel arrays. green genetic tags let us align the molecules to the reference genome and red tags denote open chromatin.

ALT Open chromatin is labeled in the nucleus by a methyltransferase and a fluorescent cofactor. labeled high molecular weight DNA is extracted and stretched for imaging in nanochannel arrays. green genetic tags let us align the molecules to the reference genome and red tags denote open chromatin.

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Yuval Ebenstein@hagenom2 Dec 2022
I’m not sure 🏝CoCoS microscopy 🏝 got the visibility it deserved but it’s the most read paper in @BiophysReports Thanks to @JJeffet @Craggs_Lab @LabPerlson
Cell Press@CellPressNews2 Dec 2022
Biophysical Reports most-read paper: Multimodal single-molecule microscopy with continuously controlled spectral resolution @biophysreports @biophysicalsoc @hagenom hubs.ly/Q01sFw280
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Happy to share our comprehensive review on how nanofluidics can be used to study DNA! cambridge.org/core/journals/…
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Awesome work by Sapir @SapirM4 on the Saphyr! 🙃 Amazing how much more useful information besides the sequence is encoded on each DNA molecule...🤯
Yuval Ebenstein@hagenom19 Oct 2022
Ultra-long single-molecule reads with methylation and hydroxymethylation tags on the @bionanogenomics Saphyr allowed to construct the genetic and epigenetic variation maps of kidney tumor and adjacent normal kidney 1/5 doi.org/10.1101/2022.10.11.5…
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At the heart of every snoutscope is a sub-micron alignment between two objectives. 1°C thermal drift kicks the lightsheet out of focus and destroys your image ☹️ Our optics room swings by 5°C/day 😭...so @AndrewGYork & I made a crossbraced O2/O3 subunit to passively compensate!
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MicroFPGA: an affordable FPGA platform for microscope control biorxiv.org/cgi/content/shor… #biorxiv_biophys
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🚨🔬😍 @afonsomendes92 @Hannah_SuperRes and @simaopc #preprint is out! An awesome collaboration with @christlet An extensive review on structural discovery and analysis with #SuperResolution using #SingleParticleAnalysis. Check it out in doi.org/10.48550/arXiv.2202.…
Afonso Mendes@afonsomendes9218 Feb 2022
🧵Hello fellow #biologists! New #preprint is out! A review on #SingleParticleAnalysis in #SuperResolution #Microscopy! Starring @hannah_superres, @simaopc, @henriqueslab, and @christlet! You’re in for a treat! @IGCiencia + @inp_marseille! doi.org/10.48550/arXiv.2202.…
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Yuval Ebenstein@hagenom14 Nov 2021
Just finished installing a new whisky cabinet in my office. Some say it’s the only ⁦@illumina⁩ whiskey cabinet in the world…
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Cees Dekker@cees_dekker4 Nov 2021
Today we publish a paper in @ScienceMagazine that expands nanopore readings to the proteome: a nanopore-based scanner to read off PROTEINS at the single-molecule level! 🤩 Awesome experiments by postdoc Henry Brinkerhoff of our #CDlab, with MD simulations of @aksimentievLab 1/x
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Woohoo!! Our 🌴CoCoS🌴 paper is going to be on the FIRST issue of @BiophysReports! cell.com/biophysreports/full… Thanks so much to @hagenom and our awesome collaborators: @Craggs_Lab @ArielIonescu @LabPerlson The amazing illustration by @ChizhikAlexey An explanatory thread… 1/15
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So to summarize: * CoCoS gives the control to set and optimise the spectral resolution. * Keeps the FOV large and the throughput high. * And it is simple to align and assemble so that everyone can enjoy the benefits of spectral imaging, even without being an optics expert! 15/
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Thanks for reading! If you have any questions I’d be more than happy to discuss! cell.com/biophysreports/full…

Multimodal single-molecule microscopy with continuously controlled spectral resolution

Color is a fundamental contrast mechanism in fluorescence microscopy, providing the basis for numerous imaging and spectroscopy techniques. Building on spectral imaging schemes that encode color into...

cell.com
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