@aksimentievLab
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We explore fascinating phenomena at the interface of physics, biology, and nanotechnology at the University of Illinois.
Loomis Laboratory, UIUC
Joined December 2019
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DNA could act like a famed gravity-defying pump | Science | AAAS science.org/content/article/…
Happy to see this out! Many thanks to Alan, Philip and the team!
1/5 DNA and DNA/protein conformations at Ångström/millisecond resolution—right in a fluorescence microscope! Check out our new GETvNA paper in @naturemethods :
nature.com/articles/s41592-0…
Want to learn about the science behind GETvNA?
Great achievement from the Nivala lab! See also in News and Views:
"Thread, read, rewind, repeat: towards using nanopores for protein sequencing" nature.com/articles/d41586-0…
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s41586-0…
The variation of the electric field around a DNA duplex is surprisingly complex. Now, a nonlocal electrostatic theory can explain most of the features seen in all-atom MD simulations. Many thanks to Alexei Kornyshev, @JonathanGHedley @KushCoshic and @LeverhulmeTrust
A theoretical analysis of the complex electric field around DNA uncovers the origin of oscillating field patterns and sheds light on the role of the solvent that surrounds the DNA.
Read go.aps.org/47hR1Bn
@JonathanGHedley @KushCoshic @aksimentievLab
#PRXBio, #PRXChem
AksimentievLab retweeted
Thrilled to share new @NatureNano paper by @FabriniGiacomo introducing genetically encoded condensate-forming RNA nanostructures🧬
doi.org/10.1038/s41565-024-0…
..and the great companion @NatureComms paper by @DrJMStewart @FrancoLabUCLA @pwkrpwkr
doi.org/10.1038/s41467-024-5…
Have a nanopore but not happy with its ion selectivity or electroosmotic effect? You can easily improve both! Find out how: pubs.acs.org/doi/10.1021/acs…
Thanks to @WanunuLab and Zuzanna Siwy for this great collaboration. Congrats to Behzad on another cover!
#MyACSCover #nanopores
Well, this project went from "Which molecule moves faster through a nanopore?" to "What is speed? That is, the answer depends on whether you measure translocation speed in base pairs/sec or nm/sec. Many thanks to @Keyserlab and @FilipBoskovic12 for a wonderful collaboration.
Somewhere along the way, we observed a rare event: a nucleic acid duplex biting its own tail! Watch the movie to the end. The A-form RNA/DNA duplex was not so hungry:) #Ouroboros
AksimentievLab retweeted
In a study led by @FilipBoskovic12 we examined how the electrophoretic transport of RNA:DNA and DNA through nanopores depends on the contour length rather than the number of base pairs. Nice blend of experiments and simulations! @aksimentievLab @acsnano 🧬🕳️⚛️ @Cambridge_Uni
Many thanks for this collaborative project that has pushed out computational technology to the limit!
Delighted to see @chalmerscccc work at the interface of nanopore sensing and cell biology published @NatureComms . Great team effort @RadfordLab @ericcells @aksimentievLab
nature.com/articles/s41467-0…
We missed you, Kush! @KushCoshic
Thank you, Sarthak, for the hooding ceremony and for being such a fantastic student! @ksarthak71
Congratulations to Hemani, our new Beckman Fellow!!!
Absolutely thrilled to continue my scientific exploration with the amazing @aksimentievLab in collaboration with the Schroeder lab.
Congratulations to Emad @emadtaj, well deserved and overdue!
Beckman honored three faculty and staff members who show visionary spirit and dedication. 🔶🔷
Emad Tajkhorshid (@emadtaj) won the faculty Vision and Spirit Award.
Teppie Peyton and Michael Marana won the inaugural Staff Spirit and Dedication Award.
▶️bit.ly/3Q2eGhY
ALT Headshots of Emad Tajkhorshid, Teppie Peyton and Michael Marana.
We are looking for postdoctoral researchers to work on the following topics: computational modeling of viruses and organelles, nanopore protein sequencing, DNA nanotechnology, and synthetic cell development. To apply, visit: my.physics.illinois.edu/subm…
Many thanks for hosting us!
Prof. Aleksei Aksimentiev @aksimentievLab and Takuya Mabuchi @MabuchiGroup visited and gave excellent talks on MD simulations in our lab. Their presentations were impressive and stimulating.
We also had a great time enjoying a Tempura Soba lunch together!
AksimentievLab retweeted
It cannot be done, they said.. It's too flexible, they said.. 😁
biorxiv.org/content/10.1101/… #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf
Such a beautiful cover!
what a nice bonus:
@NatureNano put our image of a DNA nanoturbine on the front cover to feature our #CDlab paper by @xinshi_d et al: nature.com/articles/s41565-0…
In partnership with @Sci_Ani, we produced an animation that puts our recent work on genome packaging rdcu.be/dBaXM into a broader perspective. #dna #viruses #highperformancecomputing #tcbguiuc
Unlocking the secrets of #viral genomes through computational microscopy offers new avenues for combating #infections. Supercomputers enable virtual reconstruction of virions, shedding light on their molecular programs.
bit.ly/3Vfz8PG
In our article published today @Nature , we report complete all-atom structural models of a fully packaged bacteriophage particle. Congratulations to Kush Coshic on his first publication! Many thanks to Chris Maffeo and David Winogradoff for pushing this 6-year project forward.