@LabPerlson

🔬 Molecular Neurodegeneration research group at Tel Aviv University, Israel

 Tel Aviv, Israel
www3.tau.ac.il/medicine/perlson/index.php
Joined February 2019
  • Tweets711
  • Following155
  • Followers579
14Media
In our recent paper we show that TDP43 mislocalization and condensates in axons and neuromuscular junction cause Neurodegenration in ALS by inhibiting local synthesis of mitochondrial proteins nature.com/articles/s41467-0…

Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local...

Nature Communications - Here, the authors show in human iPSC-derived motor neurons from ALS patients and a TDP-43 mouse model that axonal TDP-43 forms G3BP1 positive RNP condensates, which...

nature.com
7
29
2
133
Perlson lab retweeted
ShorterLab@ShorterLabOct 14
Multiple motor proteins regulate TDP-43 anterograde axonal transport: link.springer.com/article/10…

Multiple motor proteins regulate TDP-43 anterograde axonal transport

Acta Neuropathologica - TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is...

link.springer.com
4
4
614
Perlson lab retweeted
Brain@Brain1878Oct 6
Dwivedi and Roy review how epigenetic changes and RNA modifications work together to regulate gene expression in the brain, and propose that this interaction helps shape vulnerability and resilience to neuropsychiatric disorders. shorturl.at/Ut1V6
1
14
1
41
2,621
The Jackson Laboratory is a wonderful, collaborative place to pursue basic & translational science. On the faculty job market? I strongly encourage you to consider joining us in Bar Harbor, Maine! Apply: go.jax.org/276n55 #JAXresearch #JAXstemcellsdev

Faculty Positions

The Jackson Laboratory is inviting applications for positions at our Mammalian Genetics campus in Bar Harbor, Maine, and our Genomic Medicine campus in Farmington, Connecticut

jax.org
1
38
1
132
10,888
Perlson lab retweeted
ShorterLab@ShorterLabSep 21
Prevention of Unc13a cryptic splicing is sufficient to preserve memory: biorxiv.org/content/10.64898…

Prevention of Unc13a cryptic splicing is sufficient to preserve memory

TDP-43 dysfunction is thought to underlie frontotemporal dementia and limbic-predominant age-related TDP-43 encephalopathy, neurodegenerative dementias currently without effective therapy. Therapeu...

biorxiv.org
4
10
2,377
Perlson lab retweeted
Brain@Brain1878Jun 29
Ellis et al. show that cellular stress downregulates the ALS-associated protein STMN2 through impaired translation and stress granule-mediated mechanisms independently of TDP-43 dysfunction. shorturl.at/E4OB7
1
8
1
21
2,575
Perlson lab retweeted
ShorterLab@ShorterLabJun 11
RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons jneurosci.org/content/44/15/…

RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in...

DYT1 dystonia is a debilitating neurological movement disorder, and it represents the most frequent and severe form of hereditary primary dystonia. There is currently no cure for this disease due to...

jneurosci.org
2
11
1,352
Perlson lab retweeted
JAMA
@JAMA_currentJun 9
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord. Learn more in this Review: ja.ma/3Q8S0jq
1
25
1
76
4,981
Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link link.springer.com/article/10…

Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local...

EMBO Reports - Ribonucleoprotein (RNP) granules are dynamic, membraneless organelles that sequester translationally repressed mRNAs and RNA-binding proteins, playing a pivotal role in the...

link.springer.com
1
3
167
Perlson lab retweeted
ShorterLab@ShorterLabMar 20
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain - Walker - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/…

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of...

TAR DNA-binding protein 43 (TDP-43) is a nucleic acid-binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C-terminal low-complexity...

onlinelibrary.wiley.com
3
13
865
Perlson lab retweeted
Brain@Brain1878Feb 11
Mecca et al. investigate the role of muscle stem cells in SMA and show that their depletion disrupts neuromuscular junctions and leads to motor neuron loss in the spinal cord. They conclude that muscle stem cells represent potential therapeutic targets. shorturl.at/vIwEU
2
8
1
18
1,782
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons embopress.org/doi/full/10.10…
1
1
350
Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo researchsquare.com/article/r…

Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo

Mitochondria are the primary energy producing organelles in eukaryotic cells. Their location is tied to the cell compartment’s energy requirement. Whether mitochondria are actively transported and...

researchsquare.com
1
4
24
2,544
Perlson lab retweeted
ShorterLab@ShorterLab8 Nov 2025
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons | The EMBO Journal embopress.org/doi/full/10.10…
3
7
1,012
KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS biorxiv.org/content/10.1101/… #biorxiv_neursci

KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS

Neuronal health depends on the precise transport and local translation of mRNAs to maintain synaptic function across highly polarized cellular architecture. While kinesin motor proteins are known to...

biorxiv.org
4
18
3,502
Perlson lab retweeted
ShorterLab@ShorterLab31 Oct 2025
Cell size-dependent mRNA transcription drives proteome remodeling biorxiv.org/content/10.1101/…

Cell size-dependent mRNA transcription drives proteome remodeling

Increasing cell size drives proteomic changes that impact cell physiology. However, the molecular basis of size-dependent proteome remodeling has remained unclear. Here, we develop an inducible...

biorxiv.org
1
7
53
6,038
Read this excellent story from the @jltwiss1 lab. Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration biorxiv.org/content/10.1101/…

Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration

Nerve injury triggers localized translation of axonal mRNAs to respond to injury and nerve regeneration. The core stress granule protein G3BP1 sequesters axonal mRNAs in granules before and after...

biorxiv.org
7
14
628
Perlson lab retweeted
Brain@Brain187823 Oct 2025
O'Brien et al. demonstrate a link between ALS and extreme exercise in males which is potentially mediated via failed mTOR signalling at the neuromuscular junction. tinyurl.com/cajta7y3; tinyurl.com/ymd5c6h4
2
16
37
3,120
Drs. Yi Zeng, Aaron Gitler, and colleagues show that loss of TDP-43 from neuronal nuclei of human brain and disease-causing mutations in TDP-43 are associated with widespread changes in alternative polyadenylation. 🧠 @StanfordMed @NatureNeuro | go.nature.com/473g5Oe
1
174
Perlson lab retweeted
ShorterLab@ShorterLab22 Oct 2025
Retrotransposons unplugged: Rewiring the nervous system and wreaking havoc: Neuron cell.com/neuron/fulltext/S08…
3
17
1,775
Perlson lab retweeted
ShorterLab@ShorterLab17 Oct 2025
Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosis: biorxiv.org/content/10.1101/…

Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse...

Extra-motor symptoms are increasingly recognised in amyotrophic lateral sclerosis (ALS), encompassing cognitive, social, and behavioural deficits that can substantially impact quality of life. TAR...

biorxiv.org
1
5
754
Load more