@IwaharaLab

Biophysical research group with expertise in NMR spectroscopy

 Texas, USA
scsb.utmb.edu/labgroups/iwahara
Joined April 2022
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Our PNAS paper has been published today. We used various NMR methods, including direct measurement of electrostatic potentials. pnas.org/doi/10.1073/pnas.25…

Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the...

Oxidation of cysteine thiols to sulfonate groups (–SO3–) by reactive oxygen species can regulate protein function. Near the end of inflammation, th...

pnas.org
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It was a somewhat turbulent but good year after all. Our annual group lunch this year.
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JMB Special Issue “NMR studies of biomolecular systems” edited by Drs. Lewis Kay and Remco Sprangers. sciencedirect.com/journal/jo… Our review about ion NMR is included.
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Our special NMR probe hardware to measure diffusion of various inorganic ions in biomolecular solutions. Collaboration with @DotyScientific.
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4 faculty members who use NMR spectroscopy at Department of Biochemistry & Molecular Biology, University of Texas Medical Branch. From left: Łukasz Jaremko, Junji Iwahara, Xun Sun, and Krishna Rajarathnam.
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We are delighted to welcome two outstanding new NMR groups to UTMB: Dr. Łukasz Jaremko (from KAUST) and Dr. Xun Sun (from Scripps). Their expertise will significantly advance NMR-based biomedical research as a growing strength of UTMB.
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Our review on ion NMR for biomolecular systems: sciencedirect.com/science/ar…
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Shiny object syndrome?
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Created by ChatGPT: "I need an image that represents shiny object syndrome. The image should show a hunter who is chasing a prey in a wild field but gets distracted with shiny objects in a bush. Please make such an image."
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I am happy to share that our latest study on the effect of PTMs on nucleosome histone tail electrostatic potential with @RoesslerPhilip is out in @PNASNews pnas.org/doi/10.1073/pnas.25…

Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and...

Cellular DNA is wrapped about an octamer composed of four histone proteins forming the fundamental unit of chromatin structure, the nucleosome core...

pnas.org
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If you have ever wondered why many DNA/RNA-binding proteins have negatively charged IDRs, this review may be helpful. pubs.acs.org/doi/10.1021/acs…

Competition between Nucleic Acids and Intrinsically Disordered Regions within Proteins

Conspectus. Intrinsically disordered regions (IDRs) are important components of protein functionality, with their charge distribution serving as a key fact

pubs.acs.org
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Now, 25Mg, 33S, 35Cl, and 39K diffusion NMR measurements are feasible for biomolecular systems. The key is specialized probe hardware that can generate very strong magnetic field gradients. Contact us if you are interested. sciencedirect.com/science/ar…
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Anisotropy of protein side-chain motion can be investigated using NMR. See our latest paper. pubs.acs.org/doi/10.1021/acs…

Anisotropic Dynamics of Protein Side Chain NH2 Groups Revealed through Analysis of 2H and 15N NMR...

Abstract. Although nuclear magnetic resonance (NMR) spectroscopy is powerful for protein dynamics investigations, the anisotropy of internal motions has be

pubs.acs.org
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Sunrise at Galveston on New Year’s Day 2025. Happy New Year!
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Junji and his old friend, Prof. David Williams, guest-edited a special issue “Protein-Nucleic Acid Interactions (2024)” for Current Opinion in Structural Biology (@COSB_CRSB @elsbiomedchem). sciencedirect.com/special-is…
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So glad that our parking problem for the NMR facility has been resolved.
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We celebrated 1) our 3 JACS papers in 2024, 2) Binhan and Xi’s baby who will be born soon, 3) Junji’s 100th paper, 4) Jonathan’s return, and 5) Maria Clara’s joining the lab.
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Our collaboration with Lewis Kay’s group (@LEK_Lab) on the Gd-based electrostatic potential measurement by NMR has been published in JACS today! There are several advantages over the previous nitroxide-based method. pubs.acs.org/doi/10.1021/jac…

Gadolinium-Based NMR Spin Relaxation Measurements of Near-Surface Electrostatic Potentials of...

Abstract. NMR spectroscopy is an important tool for the measurement of the electrostatic properties of biomolecules. To this point, paramagnetic relaxation

pubs.acs.org
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Our NMR study of HMGB1 phosphorylation by PKC. pubs.acs.org/doi/10.1021/acs…

Phosphorylation by Protein Kinase C Weakens DNA-Binding Affinity and Folding Stability of the HMGB1...

Abstract. The HMGB1 protein typically serves as a DNA chaperone that assists DNA-repair enzymes and transcription factors but can translocate from the nucl

pubs.acs.org
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In the New and Notable "Transient helices with functional roles," Junji Iwahara highlights the paper "Structure and interactions of prion-like domains in transcription factor Efg1 phase separation." ow.ly/5aM450S8zhU

Transient helices with functional roles

Intrinsically disordered regions (IDRs) of proteins contribute to various cellular functions, including signal transduction, gene regulation, and subcellular organization (1). One of the most...

cell.com
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