@LEK_Lab

Lewis E. Kay Laboratory at @UofT | Using solution NMR to study supra-molecular biomolecules & rare states | Student/Postdoc Maintained

 University of Toronto
pound.med.utoronto.ca/
Joined January 2022
  • Tweets389
  • Following280
  • Followers1.1K
15Media
Had a little celebration yesterday for Lewis in honor of his 500th academic publication! The poster contains the first page of all 500 papers, and his face is made of their figures. Lewis wants to thank all his amazing trainees over the years for making it possible! #NMRchat
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We are happy to share our new perspective paper in the Journal of Magnetic Resonance, providing a brief introduction to 19F relaxation in biomolecular applications. sciencedirect.com/science/ar…
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📢 We’re hiring! @StanfordUChem is now accepting applications for a Junior Faculty Position in Chemistry (open area), with the appointment set to begin on September 1, 2026. Learn more and apply here: facultypositions.stanford.ed… #FacultyJobs #AcademicJobs #Hiring
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New paper from the @gossertlab: Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR sciencedirect.com/science/ar…
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Our new paper is out in Nature Communications. Check it out if you're interested in IDR-GQ interactions. nature.com/articles/s41467-0…

Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase...

Nature Communications - DDX3X is an RNA helicase that regulates translation by unwinding complex mRNA structures. Here the authors show that it selectively targets G-quadruplex motifs via an...

nature.com
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Check out the labs newest study! @RashikAhmed8
J. Am. Chem. Soc.@J_A_C_S
27 Aug 2025
Atomic Resolution Interactions Regulating Partitioning of a FUS Folded RRM Domain into Model CAPRIN1 Condensates | Journal of the American Chemical Society @UofT @UofTNews pubs.acs.org/doi/10.1021/jac…

Atomic Resolution Interactions Regulating Partitioning of a FUS Folded RRM Domain into Model...

Abstract. Biomolecular condensates enrich specific client molecules while excluding others, often modulating conformational landscapes, and hence functions

pubs.acs.org
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MCB @ U of Guelph is hiring (again)! 🎉 Tenure-track Assistant Professor in Biochemistry Part of our strategic cluster hire. Apply now 👉 careers.uoguelph.ca/job/Guel… #Biochemistry #FacultyJobs #AcademicTwitter #MolBio

Assistant Professor (Biochemistry)

Assistant Professor (Biochemistry)

careers.uoguelph.ca
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The Department of Chemistry in the Faculty of Arts & Science at the University of Toronto is inviting applications for a full-time tenure stream position in Experimental Physical Chemistry. Competition closes September 10, 2025 - visit us to learn more! chemistry.utoronto.ca/employ…
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on behalf of Pro James Keeler (University of Cambridge) considering the possibility of revising the text and creating a third edition : Understanding NMR Spectroscopy, James Keeler - survey concerning a possible third edition cambridge.eu.qualtrics.com/j… #NMRbooks #NMRchat #NMR 🧲
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I am happy to share that our latest study on the effect of PTMs on nucleosome histone tail electrostatic potential with @RoesslerPhilip is out in @PNASNews pnas.org/doi/10.1073/pnas.25…

Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and...

Cellular DNA is wrapped about an octamer composed of four histone proteins forming the fundamental unit of chromatin structure, the nucleosome core...

pnas.org
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👀
Philip Rößler@RoesslerPhilip
22 Jul 2025
New paper with @BolikCoulon from the @LEK_Lab: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation pnas.org/doi/10.1073/pnas.25…

Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and...

Cellular DNA is wrapped about an octamer composed of four histone proteins forming the fundamental unit of chromatin structure, the nucleosome core...

pnas.org
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The Department of Chemistry in the Faculty of Arts & Science at the University of Toronto is inviting applications for two full-time tenure stream positions in Experimental Physical Chemistry. Competition closes September 10, 2025 - visit us to learn more! chemistry.utoronto.ca/employ…
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Introducing in-cyclo NMR, a new method led by @GuillaumeMas2 at @biozentrum (@NatureComms)! This method combines high-resolution NMR with ATP regeneration & phosphate removal to resolve kinetics & dynamics of molecular machines - all in one experiment! doi.org/10.1038/s41467-025-6…
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Our new paper is out in Journal of Magnetic Resonance. Check it out if you're interested in 19F relaxation in fluorotryptophan. Evaluating the effect of 1H decoupling on 19F longitudinal relaxation ... sciencedirect.com/science/ar…
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Out in @pnas today Showcasing the power of NMR! NMR and enzyme kinetics show USP7 enzyme transiently sampling a low-populated active state, and its disease-causing variant enhancing these dynamics pnas.org/doi/10.1073/pnas.24… Stellar work by students Gabi Valles and Emilie Korchak

Activation dynamics of ubiquitin-specific protease 7 | PNAS

Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that plays a crucial role in cellular processes, including the maintenance of gen...

pnas.org
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Great job @BiochemBeth1 presenting her work with 19F NMR this weekend at the @UTorontoCBP conference.
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Bruker @bruker announces successful acceptance of 1.2 GHz NMR spectrometer at the UK High-Field Solid-State NMR Facility @NrfHf at the University of Warwick bruker.com/en/news-and-event… #NMRnews #NMRchat #NMR 🧲

Bruker Announces Successful Acceptance of 1.2 GHz NMR Spectrometer at University of Warwick

Warwick, United Kingdom – May 14, 2025 – Bruker Corporation, a global leader in scientific instrumentation, is pleased to announce the successful acceptance of its state-of-the-art 1.2 GHz NMR...

bruker.com
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Had an amazing time at @ChemBioPhys @UofT #CBP2025! Huge thanks to the organizers for the opportunity 🙌 Already looking forward to next year!
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Tired of costly cloning software? Try IVA Prime: a free, game-changing tool for automated primer design in IVA cloning! Simplify complex cloning with one click, reduce errors, and save time. Visit ivaprime.com. doi.org/10.1093/nar/gkaf386 collaboration with @JGarciaNafria
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Our May Presenter is Prof. Cavagnero from University of Wisconsin-Madison on 6/5th, 2025, Thursday, 12-1pm. This is a virtual meeting hosted by Microsoft Teams. bit.ly/4cTAdn4 Meeting ID: 272 352 880 226 Passcode: KT7NK7aT Hope to see you there!
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Meet our Keynote Speakers for #CBP2025!! We are excited to have Dr. Jung Ho Lee, Associate Professor (Seoul National University) as a keynote speaker! Dr. Lee holds a faculty position at the Chemistry Department of Seoul National University & is currently on sabbatical at UofT!
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