Studying the tumor ecosystem through a spatial lens
Joined July 2022
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Inbal Avraham-Davidi retweeted
Our new #paper is out in @NatImmunol. Applying #spatial transcriptomics at subcellular resolution to 130 ovarian #cancer tumors, followed by data-driven experimental design and high content #CRISPR screens to map immune evasion in ovarian cancer nature.com/articles/s41590-0… (1/15)
Inbal Avraham-Davidi retweeted
Curious how parents influence their teens' daily moods? 🤔 Check out our new study in Emotion! 📚 #Parenting #Adolescence #Psychology #Emotion @emotionjournal doi.org/10.1037/emo0001377 psycnet.apa.org/search/displ…
Inbal Avraham-Davidi retweeted
I’m excited to share our work on the spatial organization of GBM -- a great adventure over the past few years with wonderful friends:) I’m excited to see what the emerging world of spatial biology has in store for us & hope it will translate into clinically actionable insights.
We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.07.06.5…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/
Inbal Avraham-Davidi retweeted
Our paper is out. An amazing work led by @Avekshasharma1 and @ShaniZerbibMist and a lot of help from great scientist friends. In short, splicing makes the world go round!
@BentataMercedes @Mib_Baker @GillianK_scied @ @yotam_d
New #PLOSBiology study from @MaayanSalton &co reveals the crucial role of splicing in TAL1 isoform regulation and its impact on hematopoiesis. These findings highlight the potential of targeting splicing to combat cancer. #CancerResearch #leukemia
plos.io/3CTaslQ
ALT Data showing that the TAL1 gene codes for 6 mRNA isoforms that translate to 2 protein isoforms.
Inbal Avraham-Davidi retweeted
1. Excited to share our new paper in @Nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH)
nature.com/articles/s41586-0…
Inbal Avraham-Davidi retweeted
Postdoctoral positions still available! One to develop single cell methodology for representation learning of healing and regeneration. The second, to build inverse kinematics models of development using tools from material science, robotics & computer science. Email me your CV!
Inbal Avraham-Davidi retweeted
Very excited to share our work on tissue division of labor that is guided by cell interactions and spatial cues, a joint effort with @moriel_noa, @AleksGoeva, @mor_nitzan, and others (see below) along with my inspiring mentors @RMedzhitov and #AvivRegev. cell.com/cell-reports/fullte…
Inbal Avraham-Davidi retweeted
Excited to share our work on HPV+ head and neck cancer, led by @micmints in close collaboration with @SidPuram lab
Happy to share our latest work (nature.com/articles/s41588-0…), published in @NatureGenet, where we show that HPV is repressed in a subset of cancer cells in HPV-driven oropharyngeal cancer, making them more resistant to chemo/radiation treatment! 1/8
Inbal Avraham-Davidi retweeted
Escalating the fight for democracy and equality. Midnight protest tonight. Strike starting tomorrow in all the Israeli universities.
Inbal Avraham-Davidi retweeted
Exciting collaboration led by Asa Ben-Hur @GenomeBiology utilizing deep learning models to identify motifs of transcription factors enriched in intron retention events. #genomics #splicing#transcriptionfactors
genomebiology.biomedcentral.…
Inbal Avraham-Davidi retweeted
Excited to host Prof. Xavier w/ @BINAWIS1 ! His captivating lecture on Controllers of Barrier Defense and translational clinical research left us all feeling inspired and motivated. Amazing talk ! Thank you for sharing your expertise with us, Prof. Xavier ! @TheXavierLab
Inbal Avraham-Davidi retweeted
What is the cellular cascade leading to Alzheimer’s ? How is it different from aging ? Check out our new preprint. The beautiful work of @GreenGilad
(1/5) Excited to share our huge efforts to understand the cellular cascade underlying Alzheimer’s disease progression and untangling disease and aging process. With @naomi_habib, Philip L. De Jager, Vilas Menon, Hyun-Sik Yang and David A. Bennett
doi.org/10.1101/2023.03.07.5…
Inbal Avraham-Davidi retweeted
Super proud of my baby sister, @MoranBlecher, CEO of Nextage, for her exceptional work promoting workplace equality. In a country where progress is threatened, we must work harder to counteract the bad. #equality #leadership
Inbal Avraham-Davidi retweeted
Check out our interdisciplinary work - linking memory impairment, immune dysfunction and metabolic alterations. A great collaboration led by @stefano_suzzi with @AnnaGreka #MichalSchwartz
Our work is finally out in @NatureComms! Obese Alzheimer's mice may develop disease earlier due to immune exhaustion, our findings suggest. Thanks for the great team effort #MichalSchwartz @naomi_habib @GrekaLab #neuroimmunology #metabolism
nature.com/articles/s41467-0…
Inbal Avraham-Davidi retweeted
Now out in @NatImmunol: nature.com/articles/s41590-0… and perusable on the @SingleCellBroad (SCP1785)
Excited to share our preprint exploring post-injury tissue-level dynamics in the injured mammalian central nervous system, a great collaboration with @jiarui_ding, #AvivRegev, #JoshuaSanes and others (see below)! biorxiv.org/content/10.1101/…
Inbal Avraham-Davidi retweeted
🌮Tacco is now published in Nature Biotechnology: nature.com/articles/s41587-0… And even more importantly, the package is now also available on conda 🐍: anaconda.org/conda-forge/tac… #SingleCell #spatialomics
🌮From molecular to tissue scale (and beyond): TACCO helps you crack your (spatial) omics data!
Check out our preprint doi.org/10.1101/2022.10.02.5… and Python package github.com/simonwm/tacco
Joint work with @moriel_noa @InbalDavidi @KlughammerLab #AvivRegev @mor_nitzan et al.
🧵1/n
Inbal Avraham-Davidi retweeted
Our work on annotation transfer and decomposition of cell identities for single-cell and spatial omics data using TACCO! Led by @MagesLab, @moriel_noa, @InbalDavidi, together with @KlughammerLab,
#AvivRegev
nature.com/articles/s41587-0…
TACCO unifies annotation transfer and decomposition of cell identities for single-cell and spatial omics go.nature.com/3I99svU
Inbal Avraham-Davidi retweeted
TACCO unifies annotation transfer and decomposition of cell identities for single-cell and spatial omics go.nature.com/3I99svU
Congratulations @simonyona !
Thanks @Hujident this was only possible by being surrounded by fabulous students and colleagues.
Inbal Avraham-Davidi retweeted
(Cellular) life and death at the hands of splicing. Check out our new preprint, a great collaboration with Micha Berger’s lad and @yotam_d led by two very talented students @Avekshasharma1 @ShaniZerbibMist @IMRIC_HUJ
biorxiv.org/content/10.1101/…
