MD PhD, Computational Biologist @weizmannscience. Exploring head and neck cancer one cell at a time when not shredding pow.
Joined November 2022
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Experimentalist, computational biologist or jack-of-all trades looking for a great postdoc opportunity in Sweden? I can really recommend @SchlisioSusanne at @karolinskainst , where you can study intra-tumour heterogeneity in neuroblastoma
ki.varbi.com/se/what:job/job…
Michael Mints retweeted
We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.07.06.5…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/
Michael Mints retweeted
1. Excited to share our new paper in @Nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH)
nature.com/articles/s41586-0…
Happy to share our latest work (nature.com/articles/s41588-0…), published in @NatureGenet, where we show that HPV is repressed in a subset of cancer cells in HPV-driven oropharyngeal cancer, making them more resistant to chemo/radiation treatment! 1/8
Cell line studies showed that HPVon cells are preferentially killed by chemo/radiation, while HPVoff cells are resistant due to their non-proliferative state. We also showed that HPV DNA copy numbers are not affected, suggesting epigenetic regulation. 6/8
Here's a link to the full text:
rdcu.be/c83tP
#SingleCell
#Headandneck
#CancerResearch
#HPV
#Genomics