@IkonenLab

The Ikonen group is interested in the cell biology of cholesterol and related lipids and has developed tools to visualize their distribution and traffic.

 Helsinki, Finland
helsinki.fi/en/researchgroups/lipid-trafficking-lab
Joined January 2019
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🎉Thrilled to share our most recent work on how the lipid environment finely regulates the Golgi V-ATPase. A big THANK YOU to everyone in the Ikonen lab @IkonenLab @MiesvdStoel @rollingmeow, and our collaborators. 🔬Read more: biorxiv.org/content/10.1101/…

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

Sac1 is a conserved phosphoinositide phosphatase, whose loss-of-function compromises cell and organism viability. Here, we employed acute auxin-inducible Sac1 degradation to identify its immediate...

biorxiv.org
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New paper from our lab on how boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells, by @ShiqianLi1 et al. in @GenomeBiology 🥳
Shiqian Li@ShiqianLi126 Feb 2024
Excited to share that my last paper at Ikonen Lab @IkonenLab was finally published at Genome Biology. It is interesting journey and thank to the great supports from friends, collaborators and my supervisor Elina Ikonen. @MiesvdStoel @rollingmeow @RaivioTaneli @_YZlab @OlkkonenVesa link.springer.com/article/10…
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Happy to share our new work on human cell engineering with an improved version of auxin-inducible degron system. A great collaboration between IkonenLab @IkonenLab and Taneli Lab @RaivioTaneli in University of Helisinki. biorxiv.org/content/10.1101/…

One-step generation of auxin-inducible degron cells with high-efficiency homozygous tagging

Auxin-inducible degron (AID) technology is powerful for chemogenetic control of proteolysis. However, generation of human cell lines to deplete endogenous proteins with AID remains challenging....

biorxiv.org
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Scientist from @Rachid_Thiam and @IkonenLab report formation of supercooled liquid crystalline lipid droplets by that cholesterol esters. #lipiddroplet, #cholesterol, #lipidtime nature.com/articles/s41467-0…
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Out in @NatureComms our fine collaboration with @Rachid_Thiam and Ilpo Vattulainen on how cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols. nature.com/articles/s41467-0…

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglyc...

Nature Communications - Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG)...

nature.com
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Our work at the 21st International Conference on Systems Biology (ICSB). Intense days of exciting talks, ideas and inspiring discussions. Also my first poster designed according to #betterposter, with a magnetically attached QR code. @IkonenLab, #betterposter, #ICSB2022.
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Out in @CR_AACR our study showing that in operable #PancreaticCancer, regions distant from malignant cells already display proteomic changes related to lipid metabolism that affect prognosis and may be pharmacologically targeted. aacrjournals.org/cancerres/a…
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The call for @HiLIFE_helsinki Tenure Track Assistant and Associate Professors is open for one more month. Save the date and apply by 25.8., or share with your #lifescientist friends and colleagues if you think they would be the perfect fit for this. helsinki.fi/en/hilife-helsin…
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I'm very excited to share our new article on #mitophagy #lipids and #iron now out in @embojournal!! 🎉🙌 Congratulations Maeve Long et al, especially to our outstanding collaborators @whitworth_lab @LabGanley @IkonenLab @UmeaUniversity 🧵 1/n #teamwork embopress.org/doi/full/10.15…

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depl...

The EMBO Journal - Mitophagy removes defective mitochondria via lysosomal elimination. Increased mitophagy coincides with metabolic reprogramming, yet it remains unknown whether mitophagy is a...

link.springer.com
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We are looking for a highly motivated PhD student for our consortium to work on a project on intracellular transport and metabolism of major membrane lipids at the University of Helsinki! To find more about the position, the resear…lnkd.in/dNMN-Db4 lnkd.in/dTfMmZbM

#research #phd | EndoConnect .

We are looking for a highly motivated PhD student for our consortium to work on a project on intracellular transport and metabolism of major membrane lipids at the University of Helsinki! To find...

linkedin.com
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We are recruiting a Doctoral Researcher! Those of you who have a strong interest in cell biological approaches to study intracellular transport and metabolism of lipids are warmly encouraged to apply. @Endo_Connect @HelsinkiUniMed www2.helsinki.fi/en/open-pos…
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Are you curious about the function of DFCP1 in autophagy? Have a look at our latest preprint - we find that it is an ATPase involved in selective autophagy! @kschink @harald_stenmark @TerjeJohansen17 @VeijoS @CanCell_UiO @IkonenLab @tankiawee biorxiv.org/content/10.1101/…

ATPase activity of DFCP1 controls selective autophagy

Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in special...

biorxiv.org
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IkonenLab retweeted
Veijo Salo@VeijoS11 Jan 2022
Excited to share our collaborative effort on the role of seipin at ER-mitochondrial contact sites, now out in Cell Reports! cell.com/cell-reports/fullte…

Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial...

Combot et al. demonstrate that seipin is enriched at ER-mitochondria contact sites and that seipin deficiency leads to defective mitochondrial calcium import accompanied by a reduction in ATP...

cell.com
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STEMM Retreat is happening: The first day has been full of scientific interactions in presentations, workshop, and poster session - And most importantly we're finally meeting each other in person! @HelsinkiUniMed @helsinkiuni
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Very nice 2nd day of the @Endo_Connect kick-off meeting, great lectures of @JKlumperman and Kristiina @Ikonenlab, great opportunities for the PhDs to set up collaborations. @researchumcg, tomorrow training in communication, data management, seminar of our Dean Marian Joëls @umcg
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Know what it feels like to be an Avanti Award Winner? Dr. Elina Ikonen does! Find out what winning the award means to her, as well as insights into current lipid research trends in the Avanti Award Winner interview series! bit.ly/3APb4FJ
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Elina Ikonen has received 2021 Avanti Polar Lipids/EBSA Award that recognizes the most important European scientific contributions in the understanding of biophysics of #lipids. @HelsinkiUniMed @STEMMProgram ebsa.org/portal/prize-and-me… 🥳💐
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ORP2 couples LDL-#cholesterol exchange between late and recycling #endosomes to FAK activation and cell motility - new results by @Kohta_Takahashi et al @IkonenLab @helsinkiuni and collaborators embopress.org/doi/10.15252/e…
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New release fresh from our lab revealing how ORP2 controls FAK activation and LDL-cholesterol plasma membrane delivery by promoting bidirectional cholesterol/PI(4,5)P2 exchange between late and recycling endosomes! @HelsinkiUniMed @STEMMProgram embopress.org/doi/full/10.15…

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

The EMBO Journal - Low‐density lipoprotein (LDL)‐cholesterol delivery from late endosomes to the plasma membrane regulates focal adhesion dynamics and cell migration, but the mechanisms...

link.springer.com
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Delighted to share our mini review by Prof. Ikonen and me @IkonenLab on intracellular cholesterol flow between membranes. The mesmerizing lipid cholesterol is so well known, but its behavior still remains largely unknown. @Dev_Cell. authors.elsevier.com/c/1d4xe…
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