@LabGanley

Autophagy and mitophagy in health and disease

 Dundee
ppu.mrc.ac.uk/research/principal-investigator/ian-ganley
Joined April 2021
  • Tweets201
  • Following425
  • Followers1.2K
12Media
I want to highlight this Workshop I will be chairing with Prof Tiong Ong on Mitochondria Biology at #ESHCML2025 meeting in Estoril. We are lucky to have 3 excellent speakers, Ian Ganley @LabGanley Payam Gammage @mito_oncogene and Els Mansell @ElsyDutchy, sharing their expertise!
ESH (Haematology)@ESHaematology
27 Aug 2025
📣#ESHCML2025 PROGRAM HIGHLIGHT: WORKSHOP FOR NON-CLINICAL SCIENTISTS #1 Learn more here ➡ bit.ly/3ZQWwEa ESH-#iCMLf 27th John Goldman Conference on #CMLsm October 10-12, 2025/Estoril, Portugal Chairs: @GCC_Cortes, @timhughesCML, Daniela S. Krause #ESHCONFERENCES @icmlf
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Our latest interview is with 2025 @Official_BSCB l Hooke Medal winner Ian Ganley of the University of Dundee @mrcppu. We spoke with Ian about his career journey, his approach to mentorship and his pet snowflake moray, Eel Armstrong. journals.biologists.com/jcs/…
Professor Ian Ganley, 2025 winner of the British Society for Cell Biology (BSCB) Hooke Medal

ALT Professor Ian Ganley, 2025 winner of the British Society for Cell Biology (BSCB) Hooke Medal

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Registration for the joint Autophagy UK & Proteostasis UK meeting is now open. Going to be a great meeting and we look forward to welcoming you to Dundee!
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SAVE THE DATE!!
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Opposing roles for AMPK in regulating distinct mitophagy pathways. Check out this recent article in @MolecularCell by @LabGanley, Marianna Longo, @AnikethBishnu @Kei_Sakamoto, @CarolMacKintos1 #CellBio2024 hubs.li/Q02_YxPD0

Opposing roles for AMPK in regulating distinct mitophagy pathways

Under energetic stress, it is essential to balance dysfunctional versus healthy mitochondrial turnover. Longo and Bishnu et al. uncover a mechanism by which AMPK activation achieves this. They find...

cell.com
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New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: tinyurl.com/AMPK-ULK
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Ganley Lab retweeted
MRC PPU@mrcppu
26 Sep 2024
We are enormously grateful to the Medical Research Council (MRC)/UKRI for their generous long-term support - 34 years and counting - for our research Unit at the University of Dundee ppu.mrc.ac.uk/news/further-p… @The_MRC @UKRI_News #Dundee

Further £30 million, five-year funding boost from Medical Research Council | MRC PPU

The government’s Science and Technology Secretary, Peter Kyle, has announced a further five-year funding boost from the Medical Research Council (MRC) to continue our vital work.

ppu.mrc.ac.uk
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Out Now! Updated story on #HRI kinase as a negative regulator of #PINK1 mitophagy. We now show that the small molecule ISR inhibitor #ISRIB boosts PINK1 activation. Collaboration with @LabGanley @Rousseau_Lab @mrcppu & @GlennMasson Click here for paper shorturl.at/G0IzL
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That is Scotland☀️ 🏴󠁧󠁢󠁳󠁣󠁴󠁿 @LabGanley #Lab retreat 🏔
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Congratulations to Dr Alan Prescott who won first place in the @Official_BSCB image competition It is a set of tiled images taken from a frozen section of an eye from the mitoQC mouse (McWilliams et al. J Cell Biol. 2016) developed by @LabGanley @mrcppu buff.ly/49TLYqL
A titled microscope image of a cross section of a mouse eye.

ALT A titled microscope image of a cross section of a mouse eye.

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Very excited to share our new article reporting that #PINK1 has an impact on mitochondrial homeostasis and basal levels of #mitophagy in mouse skeletal muscles, enabling to study the pathway in mammalian tissues without overt stresses. @mrcppu @LabGanley tandfonline.com/doi/full/10.…

PINK1 regulated mitophagy is evident in skeletal muscles

PINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss...

tandfonline.com
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Congratulations Philippa @philippajane5 on a successful PhD viva! Well deserved🎉🎉🎉! Many thanks to examiners @VIKorolchuk and @amosliang2 too!
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🔬Exciting #JobAlert! 🌟Are you interested in cytoskeletons and their role in organelle biogenesis and autophagy? The @MorelLab4 are on the lookout for a skilled cell biologist to join their dynamic team.🧪 Apply now and be part of cutting-edge research! institut-necker-enfants-mala…
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Congratulations Dr Lorentzen on successfully defending your PhD thesis! Well done and we’ll deserved. Thanks also for the super hand knitted mitochondria hat! Many thanks to examiners @FloreyLab and @farnaby84 too!
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We are recruiting! Join the top university in the UK for biological sciences (REF 2021). Appointments for up to 45 Principal Investigators across all career stages (tenure-track to Professorial) are available. Details: buff.ly/3sQcVvJ
External 4 storey building at sunset.

ALT External 4 storey building at sunset.

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Many thanks @MorelLab4 for hosting me, the hospitality and showing the great science that is going on @NeckerInem. I really enjoyed my visit!
Morel Lab🇪🇺@MEMBRAMICS_lab
23 Jun 2023
enlightening and exciting seminar by @LabGanley today @NeckerInem about mitophagy interplay with AMPK and ULK1.. Thank you very much Ian for your visit to INEM!
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Ganley Lab retweeted
MRC PPU@mrcppu
18 Apr 2023
Success! First Dundee #Parkinsons patient randomized for Biogen Luminare #LRRK2 kinase inhibitor trial
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Very happy to have been able to contribute to this new understanding of PINK1 regulation! Great work @miratul_neuro
Miratul Muqit@miratul_neuro
23 Mar 2023
Just out! Our new preprint reporting interplay between the HRI kinase #ISR_pathway and #PINK1 #mitophagy_pathway. New mechanisms of #Parkinsons disease. 🙏@mrcppu lab members and collaborators @GlennMasson @Rousseau_Lab @LabGanley #TeamScience bit.ly/40y4Xmt
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The Autophagy UK Network Meeting 2023 will be held at University of Birmingham on 19-20 June 2023, organized by @VIKorolchuk and @SarkarSovan, keynotes by David Rubinsztein, @Carmine21678 and @Ivana75154822. Registration link: autophagyuk389582434.wordpre…

International Autophagy Conference

Visit the post for more.

autophagyuk389582434.wordpress.com
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Post-doc position available in Simon Wilkinson’s lab! As a current postdoc in this lab myself, I highly recommend it! And Edinburgh is one of the most beautiful cities in the UK! So if you are interested in ER-phagy, apply now! :) #autophagy @WilkoLabLife elxw.fa.em3.oraclecloud.com/…
AutophagyUK Network@autophagyuk
22 Feb 2023
Looking for a post-doc position? Interested in #ERphagy and #Cancer? Then look no further than @WilkoLabLife who have a @CR_UK funded position in beautiful Edinburgh. See below for link & details... elxw.fa.em3.oraclecloud.com/…

Postdoctoral Research Fellow

We are looking for a Postdoctoral Research Fellow.

elxw.fa.em3.oraclecloud.com
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