Group leader at Karolinska Institutet and University of Helsinki // https://xitter.cf/t.co/p0lcKTK0oh
Joined August 2009
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How does a cell remodel the ER membrane into a lipid droplet?
Excited to share our new preprint. We find that regulated opening of the seipin ring defines a functional ER–lipid droplet interface — and identify SMLR1 as a regulator of this transition.
biorxiv.org/content/10.64898…
Veijo Salo retweeted
Do you want to create customised CLEM workflows to address your unique research questions? Then join #EMBOCLEM and apply by 25 October: s.embl.org/lem27-01-x
This course is designed to equip participants with hands-on skills in Correlative Light and Electron Microscopy (CLEM) in room temperature and cryogenic conditions as well as provide a solid theoretical foundation. See you there?
📅 31 January – 5 February
📍 EMBL Heidelberg
Amazing!
A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER, which converts small lipid changes into a cooperative transcriptional response.
biorxiv.org/content/10.64898…
Veijo Salo retweeted
EasyGrid: a fully automated, modular platform for high-throughput sample vitrification for cryo-EM and cryo-ET.
nature.com/articles/s41592-0…
Huge thanks to all co-authors and collaborators, including @KlugYoel @jennifersapia17 @LabVanni @JZagoriy @nastia_incryo and many others!
Veijo Salo retweeted
My baby is a preprint🪐✨
I’m delighted to share my latest research conducted at @unifrBiology , with a special contribution from @VeijoS and @xuewusui. Check it out!🍓 biorxiv.org/content/10.64898…
Excited to see this work led by @jennifersapia17 online!
Substrate-dependent oligomerization modulates DGAT1 activity and subcellular localization biorxiv.org/content/10.64898…
Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM
Postdoctoral Researcher in Structural Biology, Helsinki jobs.helsinki.fi/job/Helsink…
Postdoctoral Researcher in In-Cell Structural Biology of Lipid Flux, KI ki.varbi.com/what:job/jobID:…
Research Assistant in Lipid Cell Biology and Advanced Imaging, KI
ki.varbi.com/what:job/jobID:…
Fantastic to see my favorite protein on cover of Science!
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.
Learn more in this week's issue: scim.ag/47FPKoj
ALT Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.
Fantastic work from Rasmus finally online!
Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work:
biorxiv.org/content/10.1101/…
Thank you to all coauthors for your amazing work!
Veijo Salo retweeted
Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work:
biorxiv.org/content/10.1101/…
Thank you to all coauthors for your amazing work!
Veijo Salo retweeted
Mark your calendars & repost! Join us for the 2026 FASEB Lipid Droplets Conference!
July 26-30, 2026 in beautiful Scottsdale, Arizona.
Best of all: The FASEB Lipid Droplet meeting is co-locating with the FASEB Phospholipid meeting. Two wonderful lipid communities together!
Veijo Salo retweeted
We are looking for a postdoc for an ERC funded project at @AlbertPol10 Lab at @idibaps in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Com and join us! clinicbarcelona.org/uploads/…
Excited to be giving a talk tomorrow at Karolinska. If anyone is in the area, do come check it out! news.ki.se/calendar/seminar-…
Short piece on my favorite protein!
Can you hold a soap bubble without releasing it from the bubble blower ring?
Seipin, the favourite protein of Veijo Salo, PostDoc at EMBL Heidelberg, can! Its bubbles are made of fat, which is thus stored for later use.
Read more here: embl.org/news/people-perspec…
Veijo Salo retweeted
Interesting preprint from Ikonen lab! Golgi V-ATPase is a critical effector of Sac1-mediated PI(4)P/cholesterol exchange, controlling Golgi function.
Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol biorxiv.org/content/10.1101/…
