Research group of Prof. Doeke Hekstra | Harvard Department of Molecular & Cellular Biology
Cambridge, MA
Joined January 2021
- Tweets84
- Following168
- Followers496
- Likes72
Hekstra Lab retweeted
1/5
Ensembles are hot in structural biology!
But here’s a question we don’t ask enough:
What information survives measurement and processing?
In our latest blog, @PilarCossio2 @EmilThomasen and @mhli41 have a think 🤔:
rs-station.github.io/2026/08…
🤖 Made with AI
Hekstra Lab retweeted
You shouldn’t have to have access to a GPU in-house to run ROCKET 💸 Phenix now hosts it on a server (free for academics rocket-9.gitbook.io/rocket-d…). Try phenix.rocket and reach out if you need help – this is brand new! 15/15
Hekstra Lab retweeted
ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH
Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15
Hekstra Lab retweeted
Excited to share my undergraduate work @biorxivpreprint w/ @HekstraLab and @mklureza: "Mapping protein conformational landscapes from crystallographic drug fragment screens." Check it out: doi.org/10.1101/2024.07.29.6…
Hekstra Lab retweeted
Brookner and Hekstra: MatchMaps: non-isomorphous difference maps for X-ray crystallography #XRayCrystallography #OpenSourceSoftware #DifferenceMaps @harvard... #IUCr journals.iucr.org/paper?S160…
Hekstra Lab retweeted
@SBGrid eLife paper has received a citation in April from @RachelleGaudet from @Harvard in @CellReports: Structural basis of ligand specificity and channel activation in an insect gustatory receptor.
Read more here: buff.ly/3JUEJE8
#SBGrid #structuralbiology
Hekstra Lab retweeted
💎 New #keedylab Preprint💎 biorxiv.org/content/10.1101/… We stumbled upon the highest-res dataset for apo WT PTP1B (n=350 total PTP1B structures @buildmodels). The 2 protein chains have diff degrees of disorder - allowing a direct, controlled comparison of protein conformation(s).
Hekstra Lab retweeted
Two Undergraduates Win Hoopes Prize for Research Conducted in the @HekstraLab. The summary of their thesis also provides a nice glimpse at the exciting work going on in Doeke Hekstra's lab! mcb.harvard.edu/department/n…
Hekstra Lab retweeted
Tomorrow, 5/9 at 12pm EDT, please join us for a presentation on Careless from Kevin Dalton, PhD, @HekstraLab @Harvard. Webinar & registration details: buff.ly/36OEPwR
Hekstra Lab retweeted
Outstanding eLife paper from @shamayeetaray, with a supporting cast that includes @SamPinzkaBerry, @abhisekhsingha1 @EricWil39327976, @mrinal1989: High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter doi.org/10.7554/eLife.84006
Hekstra Lab retweeted
Newly available through SBGrid is software Careless from @HekstraLab @Harvard, which performs scaling, merging, & French-Wilson corrections in a single step by directly inferring structure factor amplitudes from unscaled, unmerged intensities. Learn more: buff.ly/3XXr9VX
Hekstra Lab retweeted
A unifying Bayesian framework for merging X-ray diffraction data dlvr.it/SfPvRp #MachineLearning #NatureJournal #AI
Hekstra Lab retweeted
Excited to share our pre-print on prospectively predicting fragment binding poses with long MD simulations!
Our article "Discovery and validation of the binding poses of allosteric fragment hits to PTP1b: From molecular dynamics simulations to X-ray crystallography" has been released on bioRxiv. doi.org/10.1101/2022.11.14.5…
Hekstra Lab retweeted
Thinking of graduate school in the life sciences? Come learn about Harvard's PhD programs and how to apply! I'll be there, representing Biophysics!
We can't wait to meet you at our 2022 Virtual Open Houses (Thurs 10/13 and Tues 10/18, 5-7pm EST)!
✅Learn about our life sciences PhD programs
✅Connect w/ program representatives
✅Learn how you can strengthen your application
Register here: forms.gle/vuaE4xWKCFVYw1nm6
Pls RT🧪🧬
ALT Flyer for Harvard Integrated Life Sciences 2022 Virtual Open Houses. Event dates: October 13 and 18, 5-7pm EST PhD programs: Bioinformatics & Integrative Genomics Biological & Biomedical Sciences Biological Sciences in Public Health Biophysics Chemical Biology Chemistry & Chemical Biology Immunology Molecular & Cellular Biology Neuroscience Organismic & Evolutionary Biology Speech & Hearing Bioscience & Technology Systems, Synthetic, & Quantitative Biology Virology Registration link: https://forms.gle/UG13hghoMYx4qW4BA
Hekstra Lab retweeted
A successful end to the 57th Erice School co-directed with @goodwingroupox ! Also shown: Hans-Beat Buergi and the fantastic bio diffuse scattering crew 😊
Hekstra Lab retweeted
Excited to share our latest work revealing a repressive methylation ceiling in EZH2-mutant lymphoma! We made this discovery by finding drug addiction mutations, a strategy we expect to be broadly useful for uncovering new biology across drug targets. (1/7)
biorxiv.org/content/10.1101/…
Hekstra Lab retweeted
Staff Spotlight: Lindsay Guest (MCO Program Administrator) @lind5ayg @FanuelMuindi @JAManning15 mcb.harvard.edu/department/n…
Hekstra Lab retweeted
Open search in my department! academicpositions.harvard.ed…
Hekstra Lab retweeted
Looking forward to have @HekstraLab give the first colloquium of the semester in our department tomorrow:
Hekstra Lab retweeted
I reviewed the preprint on reciprocalspaceship, a python library for crytsallographic data. TL;DR looks very useful, will be doing some data deep dives with it soon! disq.us/p/2hbgb3h
