Associate Professor, Computational biophysicist @UofT @UTM_CPS https://xitter.cf/t.co/KIIYCdYIKj @sarahrauscher (🦋)
Toronto, Ontario
Joined August 2018
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Sarah Rauscher retweeted
3) This is a collaborative project with the @meshorer1 lab, and the @RauscherLab lab.
Talking about @RauscherLab, they have recently presented an elaborate MD-based model of the effects of PEG on the FP mCherry, a work we took part in (see doi.org/10.1101/2024.05.07.5…).
Sarah Rauscher retweeted
It is almost happening - #BPS2025 - and we are happy to attend and present our research.
A thread.
1) I will give a talk Saturday morning @ Biological Fluorescence subgroup, presenting the work spearheaded by the PhD student Khalil Joron, about
We are excited to share our recent simulation study by PhD student Ethan Lee describing the conformational states of the active site loops of the main protease (MPro) of SARS-CoV-2, featured on the cover of Biochemistry --
New issue! đź“Ł
Read up on biased signaling, RNA editing, gut microbes, antibiotics and more!
pubs.acs.org/toc/bichaw/64/1
Cover art: Lee & Rauscher @UofT explore flexible loops in the main protease of SARS-CoV-2, with implications for drug discovery.
pubs.acs.org/doi/10.1021/acs…
In this work, we use all-atom MD simulations to investigate the molecular basis for the difference between human and rhesus TRIM5α in their ability to restrict HIV. See our manuscript by Liam Haas-Neill, Deniz Meneksedag-Erol & Ibraheem Andeejani --
An all-atom view into the disordered interaction interface of the TRIM5α PRYSPRY domain and the HIV capsid biorxiv.org/cgi/content/shor… #biorxiv_biophys
Our simulations study describing the conformational states of the active site loops of the main protease (MPro) of SARS-CoV-2 is now published in Biochemistry --
pubs.acs.org/doi/10.1021/acs…
Sarah Rauscher retweeted
IDPSeminars returns this week! Sign up here! idpseminars.com
ALT Emma Morrison: Deciphering the Dynamic Language of the Histone H3 tail Sarah Rauscher: Using All-Atom Molecular Simulations to Study the Effects of Perturbations on Intrinsically Disordered Regions
Sarah Rauscher retweeted
We have an open position for studying two-pore domain potassium channels using MD simulations and single-particle Cryo-EM. Please help us spread the word: leibniz-fmp.softgarden.io/jo…
The Department of Physics at the University of Toronto is recruiting candidates in Theoretical Biological Physics for a tenure track Assistant, Associate or Full Professor.
UofT has a vibrant biophysics community -- please join us!
physics.utoronto.ca/physics-…
Sarah Rauscher retweeted
If you want to see what a comprehensive computational analysis of SH2 domain structure and dynamics in an oncoprotein looks like, with a little HDX thrown in on the side, then this here @RauscherLab paper is for you!
Sharing our preprint - an investigation into the effects of an oncogenic driver mutation on the structure and dynamics of an SH2 domain. We tested our simulation predictions using HDX-MS experiments in collaboration with Derek Wilson at York University. @dkwilson2
Please join us in congratulating the first PhD graduate from the Rauscher lab, Dr. Eugene Klyshko @klyshko_to! We took a moment this week to celebrate his successful PhD defense.
Sharing our preprint - an investigation into the effects of an oncogenic driver mutation on the structure and dynamics of an SH2 domain. We tested our simulation predictions using HDX-MS experiments in collaboration with Derek Wilson at York University. @dkwilson2
The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain biorxiv.org/cgi/content/shor… #biorxiv_biophys
Excited to share our recent simulation study on the main protease of SARS-CoV-2 — preprint on bioRxiv —
The Conformational Space of the SARS-CoV-2 Main Protease Active Site Loops is Determined by Ligand Binding and Interprotomer Allostery biorxiv.org/cgi/content/shor… #biorxiv_biophys
Sarah Rauscher retweeted
📜 Just published online... 🎉- Single-particle #CryoEM and MD #simulations: A perfect match - by Lars @Pogoscience, Maxim @maxotubule and Helmut. sciencedirect.com/science/ar… Happy reading!
Sarah Rauscher retweeted
Say it louder for the people in the back.
PEG is not inert!
Looking forward to reading this one more in depth. – at Bethesda, MD
A recent manuscript, “PEG-mCherry interactions beyond classical macromolecular crowding,” by Liam Haas-Neill from our lab and Khalil Joron from the lab of
@eitan_lerner
is out, preprint on bioRxiv:
biorxiv.org/content/10.1101/…
A recent manuscript, “PEG-mCherry interactions beyond classical macromolecular crowding,” by Liam Haas-Neill from our lab and Khalil Joron from the lab of
@eitan_lerner
is out, preprint on bioRxiv:
biorxiv.org/content/10.1101/…
We find that PEG-wrapping around the side chains of lysine residues is prevalent, occurring in at least 20% of all crystal structures containing PEG, which corresponds to approximately 0.4% of all structures in the PDB.