@HarrisTryonLab

Welcome! We are uncovering how the skin influences the skin microbiome. Check out our recent work! https://xitter.cf/t.co/wDNTkSY5pX

 Dallas, TX
utsouthwestern.edu/labs/harris-tryon/
Joined May 2019
  • Tweets1.2K
  • Following728
  • Followers986
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1/11 Ever wondered why men have more S. aureus infections than women? Check out how testosterone stimulates S. aureus through activation of quorum sensing in our @harristryonlab preprint. Led by M. Sindhura John PhD @UTSWDerm. A #microbiome #staph#mrsa🧵 biorxiv.org/content/10.1101/…

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum...

Staphylococcus aureus, the most frequent cause of skin infections, is more common in men than women and selectively colonizes the skin during inflammation. Yet, the specific cues that drive infection...

biorxiv.org
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Replying to @MohiniB1
Congratulations!!!
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Thursday at #SIDChicago26 features 4 distinguished lectures: ✅ Melanoma therapeutics (Roger Lo) ✅ Hair follicle biology (Peggy Myung) ✅ Dermato-epidemiology (David Margolis) ✅ Microbiome homeostasis (Tamia Harris-Tryon) May 14 | More info: sidnet.org/meetings-events/2……d-t
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Honored to share our work @SocInvestDerm 2026, on the skin, and how the immune system, the endocrine system, and the skin microbes interface. Our latest is now in press published with @natureportfolio.nature.com Nature Microbiology! #research. rdcu.be/e50PE
Society for Investigative Dermatology@SocInvestDermMar 6
Tamia Harris-Tryon, MD/PhD (UT Southwestern) presents on immune-endocrine regulation of the skin microbiome. Her lab investigates how resident microbes shape the skin barrier + contribute to inflammatory disease. See Thursday's schedule: sidnet.org/annualmeeting/sch… #SIDChicago26
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Replying to @andrewlji
Thanks Andrew!
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Replying to @itchdoctor @SpringerNature @NatureMicrobiol
Thank you @itchdoctor!
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Read my latest #research on #staph interactions with skin #androgens, published with @SpringerNature in @NatureMicrobiol rdcu.be/e50PE
Nature Microbiology@NatureMicrobiolMar 5
Our March issue is out: 🤖the promise and pitfalls of AI 🙅gasdermins thwarting bacterial pathogens 🌽Trichoderma fungi for sustainable agriculture 🐛mechanisms of insect-bacterium mutualism 🫘microbiome impacts on chronic kidney disease ...and more 👇 nature.com/nmicrobiol/volume…
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HarrisTryon Lab retweeted
HarrisTryon Lab@HarrisTryonLabMar 2
Exciting to have our findings out after peer review!!! The skin generates sex steroids in nanomolar to micromolar amounts, depending on the sex steroid and the skin site. Specifically skin androgens regulate S. aureus quorum sensing.
Nature Microbiology@NatureMicrobiolFeb 28
Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing dlvr.it/TRCQqx #MicroSky

Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing

Nature Microbiology - Testosterone produced by skin cells enhances Staphylococcus aureus pathogenicity by activating quorum sensing, and a stereoisomer of testosterone that blocks this interaction...

nature.com
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HarrisTryon Lab retweeted
HarrisTryon Lab@HarrisTryonLabMar 2
utsouthwestern.edu/newsroom/…

Testosterone increases severity of bacterial skin infections

Men are more susceptible than women to skin infections caused by Staphylococcus aureus bacteria, but the biological basis for this disparity has remained unclear. A new study led by UT Southwestern...

utsouthwestern.edu
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utsouthwestern.edu/newsroom/…

Testosterone increases severity of bacterial skin infections

Men are more susceptible than women to skin infections caused by Staphylococcus aureus bacteria, but the biological basis for this disparity has remained unclear. A new study led by UT Southwestern...

utsouthwestern.edu
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HarrisTryon Lab retweeted
Marciano Lab@marciano_denise20 Feb 2024
Really beautiful work from the Harris-Tryon lab. A must read!! Congrats!
HarrisTryon Lab@HarrisTryonLab20 Feb 2024
1/11 Ever wondered why men have more S. aureus infections than women? Check out how testosterone stimulates S. aureus through activation of quorum sensing in our @harristryonlab preprint. Led by M. Sindhura John PhD @UTSWDerm. A #microbiome #staph#mrsa🧵 biorxiv.org/content/10.1101/…

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum...

Staphylococcus aureus, the most frequent cause of skin infections, is more common in men than women and selectively colonizes the skin during inflammation. Yet, the specific cues that drive infection...

biorxiv.org
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Skin androgens affect virulence of Staphylococcus aureus dlvr.it/TRCQtv #MicroSky

Skin androgens affect virulence of Staphylococcus aureus

Nature Microbiology - Sex-specific differences in susceptibility to skin infections with Staphylococcus aureus are well described. Testosterone now emerges as a direct modulator of the accessory...

nature.com
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Exciting to have our findings out after peer review!!! The skin generates sex steroids in nanomolar to micromolar amounts, depending on the sex steroid and the skin site. Specifically skin androgens regulate S. aureus quorum sensing.
Nature Microbiology@NatureMicrobiolFeb 28
Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing dlvr.it/TRCQqx #MicroSky

Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing

Nature Microbiology - Testosterone produced by skin cells enhances Staphylococcus aureus pathogenicity by activating quorum sensing, and a stereoisomer of testosterone that blocks this interaction...

nature.com
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Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing dlvr.it/TRCQqx #MicroSky

Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing

Nature Microbiology - Testosterone produced by skin cells enhances Staphylococcus aureus pathogenicity by activating quorum sensing, and a stereoisomer of testosterone that blocks this interaction...

nature.com
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Replying to @Soumees @UTSWDerm
Thanks @Soumees! Ill be at UCSF- Dermatology 4/29 presenting this work and other findings from our group!
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HarrisTryon Lab retweeted
Mohini B@MohiniB1Feb 28
This was such a cool study to be a part of! Congrats to the Harris-Tryon group @HarrisTryonLab
Nature Microbiology@NatureMicrobiolFeb 28
Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing dlvr.it/TRCQqx #MicroSky

Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing

Nature Microbiology - Testosterone produced by skin cells enhances Staphylococcus aureus pathogenicity by activating quorum sensing, and a stereoisomer of testosterone that blocks this interaction...

nature.com
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The JID January cover video features #Steroid Synthesis in Cutaneous Cells youtu.be/xqZoOti5XmM For more detail, see the article by Sturges et al @HarrisTryonLab "Cutaneous Hormone Sampling and Analysis for Dermatological Research”. (doi.org/10.1016/j.jid.2025.0…) #dermtwitter #dermatology #dermscience #dermresearch

JID January 2026 Cover: Steroid Synthesis in Cutaneous Cells

steroids, sex steroid, sex steroid synthesis, hormones, sebaceous g...

youtube.com
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Great summary of what is known about S. aureus/skin dynamics. We are exciting to be expanding the picture with our findings demonstrating how the skin secretes hormones and how testosterone stimulates QS in S. aureus. pubmed.ncbi.nlm.nih.gov/4051… biorxiv.org/content/10.1101/…

Cutaneous Hormone Sampling and Analysis for Dermatologic Research - PubMed

The skin can generate hormones through de novo steroid hormone synthesis. These hormones have been shown to play a significant role in inflammatory skin conditions through the regulation of skin...

pubmed.ncbi.nlm.nih.gov
JID Innovations
@jidinnovations29 Jul 2025
From the July issue: How does the #microbiome impact #eczema? Check out this review to find out what we know, and the questions that remain ow.ly/W6nL50VNIAi #medderm #dermtwitter
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From the July issue: How does the #microbiome impact #eczema? Check out this review to find out what we know, and the questions that remain ow.ly/W6nL50VNIAi #medderm #dermtwitter
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Congrats to all on a labor of love. I recall "pd-1 is boring" as a grant review comment. Not so boring in fact... nature.com/articles/s41590-0…

PD-1 is requisite for skin TRM cell formation and specification by TGFβ

Nature Immunology - Anandasabapathy and colleagues show that the inhibitory receptor PD-1 impacts the specification of tissue-resident memory T cells in the skin.

nature.com
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Replying to @kvnforsberg @cellhostmicrobe @luis840alberto
Congratulations!!
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