@GrabowiczLab

Bacterial genetics lab interested in antibiotic resistance @EmoryUniversity 🇦🇺🇺🇸

 Atlanta, GA
grabowiczlab.com
Joined October 2018
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Congratulations to Dr @J_Marotta for awesome an PhD defense today!! @EmoryMMG @EmoryMicrobio @EmoryARC
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Unlike Boeings, LolCDE is built tough. Took a lot to break this lipoprotein transporter! See the latest from the lab in @mbiojournal journals.asm.org/doi/10.1128…

Genetic analysis reveals a robust and hierarchical recruitment of the LolA chaperone to the LolCDE...

Resistance to current antibiotics is increasingly common. New antibiotics that target essential processes are needed to expand clinical options. For Gram-negative bacteria, their cell surface—the...

journals.asm.org
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Congratulations to Dr Hannah Smith from @GrabowiczLab who was awarded her PhD today!!! Awesome!!!
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NlpE is an amazingly adaptable sensor of all sorts of stress. See new stories from @JFClab & @EzratyB: pnas.org/doi/10.1073/pnas.22… & from @traivio & @TimCho17: biorxiv.org/content/10.1101/…
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She also asked #AlphaFold how NlpE:CpxA might interact… via her NlpE loop! Mutating the predicted interacting residues in CpxA blinds the sensor to NlpE (though not other stressors)! Eerily accurate prediction that matches the genetics!
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Our first #AlphaFold wow moment! Lipoproteins like NlpE detect cell envelope stress, but how? @J_Marotta decided to find out, discovering a key loop in NlpE. Mutants can’t activate the CpxA sensor kinase to signal stress. onlinelibrary.wiley.com/doi/…

Molecular insights into Escherichia coli Cpx envelope stress response activation by the sensor...

We reveal the molecular details of how the sensor lipoprotein NlpE activates the Cpx two-component stress response. Through complementary genetics, biochemistry, and AlphaFold2 modeling, we identif...

onlinelibrary.wiley.com
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Elegant solution for a big problem. Very nice work
Nature Microbiology@NatureMicrobiol
1 Mar 2023
OUT NOW @Nature 👀Coordination of bacterial cell wall and outer membrane biosynthesis nature.com/articles/s41586-0…

Coordination of bacterial cell wall and outer membrane biosynthesis

Nature - A study demonstrates that specific interactions between the two committed enzymes for the synthesis of lipopolysaccharide and peptidoglycan enable coordinated assembly of the outer...

nature.com
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New! Gram- cells need lipoproteins to build their surface. LolA & LolB deliver these in E.coli. But many species only have LolA - where's LolB? For Caulobacter, LolB is... LolA! It's a bifunctional protein! We can even tweak E.coli LolA to do double duty! pnas.org/doi/10.1073/pnas.22…

Teasing apart the evolution of lipoprotein trafficking in gram-negative bacteria reveals a bifunc...

The outer membrane (OM) is the defining feature of gram-negative bacteria and is an essential organelle. Accordingly, OM assembly pathways and thei...

pnas.org
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Replying to @DWeissLab
Congratulations David!
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Huge congrats to Dr Kelly Lehman! First PhD student from the Grabowicz Lab 🎉🎉🎉
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Awesome work from our friends & neighbors @DorisLaRock & @LaRockLab at @EmoryMedicine!
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Faculty Position available in bacterial infection and host interaction at the @EmoryVaccineCtr. Applications from women and individuals from historically under-represented groups are strongly encouraged to apply nature.com/naturecareers/job…
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Always amazing to visit the bacteria mecca @UWBact, thank you for the invitation @markmandel!
Mark Mandel@markjmandel
2 Dec 2021
Excited to have Marcin @GrabowiczLab here for the @UWBact seminar this afternoon!
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Drown them in their own garbage: a new strategy to reverse polymyxin resistance? pubmed.ncbi.nlm.nih.gov/3484… Interesting new insights into polymyxin resistance from @m_strent lab journals.asm.org/doi/10.1128…

Drown Them in Their Own Garbage: a New Strategy To Reverse Polymyxin Resistance? - PubMed

Purcell and colleagues offer new insights into a major mechanism of polymyxin resistance in Gram-negative bacteria (A. B. Purcell, B. J. Voss, and M. S. Trent, J Bacteriol 204:e00498-21, 2022,...

pubmed.ncbi.nlm.nih.gov
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Can’t wait to read this one by @QuaveEthnobot!
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Wow! These structures are amazing!
Dr Matthew Doyle@DoyleMT1
25 Aug 2021
** OUR NEW @biorxivpreprint ** In this work we target the major longstanding questions regarding how membrane protein barrels are folded - a conserved and essential process in the majority of life forms. THREAD 1/n biorxiv.org/content/10.1101/…

Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding

Transmembrane β-barrel proteins are folded into the outer membrane (OM) of Gram-negative bacteria by the β-barrel assembly machine (BAM) via an unexplained process that occurs without known external...

biorxiv.org
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This is very cool! nature.com/articles/s41564-0…

β-Barrel proteins tether the outer membrane in many Gram-negative bacteria

Nature Microbiology - β-barrel outer-membrane proteins are covalently attached to peptidoglycan in Gram-negative bacteria including Coxiella burnetii, Agrobacterium tumefaciens and Legionella...

nature.com
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Goodbye to our congressman and an incredible human. Will forever remain an inspiration
The New York Times
@nytimes
18 Jul 2020
Breaking News: John Lewis has died at 80. A towering figure in the historic struggle for racial equality, he carried a mantle of moral authority into Congress. nyti.ms/3h8Uze4

John Lewis, Towering Figure of Civil Rights Era, Dies at 80 (Published 2020)

Images of his beating at Selma shocked the nation and led to swift passage of the 1965 Voting Rights Act. He was later called the conscience of the Congress.

nytimes.com
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🎉 Grad student Kelly Lehman awarded an @NIAIDTraining F31 NRSA fellowship!! Fantastic news, super proud PI and labmates!
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Future classic: a rational, unbiased approach for testing how well lab/animal models reflect infections. This will settle so many arguments mbio.asm.org/content/11/1/e0…
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