@TimCho17

Graduate Student in the Raivio lab studying how bacteria sense and respond to stresses @UAlberta

 Edmonton, Alberta
Joined June 2019
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  • Following104
  • Followers44
5Media
Super happy to see this out! Thank you to all current and previous @traivio and Glover lab people for making this project possible. An especially big shoutout to my talented co-author Cameron Murray for providing indispensable expertise and insight. 🔬🦠 jbc.org/article/S0021-9258%2…

The sensor of the bacterial histidine kinase CpxA is a novel dimer of extracytoplasmic Per-ARNT-Sim...

Histidine kinases are key bacterial sensors that recognize diverse environmental stimuli. While mechanisms of phosphorylation and phosphotransfer by cytoplasmic kinase domains are relatively well-c...

jbc.org
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Why do Pseudomonas aeruginosa have not one, but two MlaA-like proteins? Turns out that one protein is part of a classic maintenance of lipid asymmetry pathway while the other joins forces with a periplasmic phospholipase!   pnas.org/doi/10.1073/pnas.23…

A periplasmic phospholipase that maintains outer membrane lipid asymmetry in Pseudomonas aeruginosa...

The outer membrane of Gram-negative bacteria is unique in both structure and function. The surface-exposed outer leaflet is composed of lipopolysac...

pnas.org
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New! Gram- cells need lipoproteins to build their surface. LolA & LolB deliver these in E.coli. But many species only have LolA - where's LolB? For Caulobacter, LolB is... LolA! It's a bifunctional protein! We can even tweak E.coli LolA to do double duty! pnas.org/doi/10.1073/pnas.22…

Teasing apart the evolution of lipoprotein trafficking in gram-negative bacteria reveals a bifunc...

The outer membrane (OM) is the defining feature of gram-negative bacteria and is an essential organelle. Accordingly, OM assembly pathways and thei...

pnas.org
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the first plate i pour vs the last plate i pour
ᐯIᑕTOᖇ ᑎIᘔET@victornizet
17 Jan 2023
#Microbiology
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#PeerReview from @eLife of 👉🏿 A frameshift in Yersinia pestis rcsD leads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles biorxiv.org/content/10.1101/… #biorxiv_micrbio #reviewedpreprint
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I’m excited to share our historical perspective on the outer membrane of Gram-negative bacteria! Here, we dive into the experiments that have built our understanding of outer membrane structure, function, and biogenesis. sciencedirect.com/science/ar…
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A review I co-wrote on ESRs with my talented labmate @kpick97 (and the one and only @traivio) is finally out! It's a chonker but we hope it becomes a useful resource for people to learn about these key bacterial systems! authors.elsevier.com/c/1g9xg…
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Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. elifesciences.org/inside-eli…
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Our preprint on how lipoprotein-OMP complexes mediate signaling from the outer membrane was just uploaded to bioRxiv! Give it a read if you got some time.
bioRxiv Microbiology@biorxiv_micrbio
20 Oct 2022
NlpE is an OmpA-associated outer membrane sensor of the Cpx envelope stress response biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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@traivio fyi!
Over at @eLife, we’re eliminating accept/reject decisions and relinquishing the traditional journal role of gatekeeper. This new model is our move towards a fairer system that helps researchers get recognition for what, not where they publish. Read more: elifesciences.org/articles/8…
A schematic with symbols demonstrating the 5 steps of the new eLife publishing model with steps 1 to 5 as follows: Submission, Peer review, publication, author revision and version of record.

ALT A schematic with symbols demonstrating the 5 steps of the new eLife publishing model with steps 1 to 5 as follows: Submission, Peer review, publication, author revision and version of record.

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NlpE is an OmpA-associated outer membrane sensor of the Cpx envelope stress response biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Busy on the Caulobacter project with @LaskerKeren -- I worked up the cell wall this morning. First time doing an S-layer! Wow! It's still missing the soluble periplasmic proteins and all the inner membrane proteins at the condensate.
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DNA Enzymes explained with earphones 🧬🎧
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idk how they found footage of me whenever costco restocks john wm macy's cheese crisps
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new yeezys just dropped 🔥🔥🔥
Tom Ellis@ProfTomEllis
12 Aug 2022
Cellulose shoes made by bacteria | Nature Biotechnology short profile of our collaborators and friends at Modern Synthesis nature.com/articles/s41587-0…
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a photo of me doing simple dilutions without a calculator
a cute puppy with a "certificate of bravery"

ALT a cute puppy with a "certificate of bravery"

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Simulated colonic fluid replicates the in vivo growth capabilities of Citrobacter rodentium cpxRA mutants and uncovers additive ... biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Scissors? You mean Parafilmase?
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