@DWeissLab

Professor at Emory, Director of @EmoryARC, working with an incredible team in the Weiss Lab to take down antibiotic resistant superbugs.

 Atlanta, GA
Joined May 2017
  • Tweets408
  • Following471
  • Followers1.5K
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So thrilled this story is now published! Huge thank you to @PLOSBiology! @grakoui @anuradhaiitm
DWeissLab@DWeissLab
5 Sep 2023
Bacteria in our BRAINS?? Surprisingly, we observe translocation of gut bacteria to the brain via the vagus nerve. This occurs in mice fed a high fat diet, or without dietary changes in mouse models of Alzheimer’s, Parkinson’s, and autism. 🧵 biorxiv.org/content/10.1101/…
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Thank you so much to Jenny Lehmann @itsJennyLemon and @DiscoverMag for this wonderful write up of our paper! discovermagazine.com/how-a-h… @grakoui @anuradhaiitb

How a High-Fat Diet Sent Living Gut Bacteria into the Brain — and Why This Mouse Study Raises Big...

Learn how feeding mice a high-fat diet can weaken their gut barrier, allowing bacteria to enter the brain, which suggests a connection to neurodegenerative disease.

discovermagazine.com
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Big thank you to @liuswrites for this wonderful piece about our study! We found that gut bacteria can escape to the brain via the vagus nerve in settings of high-fat diet or in models of Alzheimer's, Parkinson's, and autism. the-scientist.com/a-high-fat…

A High-Fat Diet May Drive Gut Bacteria to the Brain in Mice | The Scientist

Researchers discovered that gut bacteria could travel to the brain via the vagus nerve in mice, offering clues to the gut-brain axis’ involvement in some neurological disorders.

the-scientist.com
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Bacteria in our BRAINS??! We observed translocation of bacteria from the gut to the brain via the vagus nerve. This occurred after high fat diet, or without dietary changes in mouse models of Alzheimer’s, Parkinson’s, and autism. journals.plos.org/plosbiolog…

Translocation of bacteria from the gut to the brain in mice

Recent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial...

journals.plos.org
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In all models tested, bacterial translocation to the brain correlated with gut dysbiosis and intestinal barrier permeability, and the bacteria reaching the brain were always found in the gut. We hope other researchers will investigate these findings and share their results.
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This was an amazing collaboration with Arash Grakoui @grakoui and an exceptional team, especially Manoj Thapa, @anuradhaiitb. Chui-Yoke Chin, Jacob Choby and many others. Big thank you to @PLOSBiology! @BWFPATH, @alzassociation
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“The rise of NDMs in the U.S. is a grave danger and very worrisome,” said David Weiss, an Emory University infectious diseases researcher, Read more about a new study that found a 461% increase in CP-CRE cultures in the US that had NDM genes #AMR nbcnews.com/health/health-ne…

‘Nightmare bacteria’ cases are increasing in the U.S.

It’s likely that many people are unrecognized carriers of the drug-resistant bacteria, which could lead to community spread, CDC scientists said.

nbcnews.com
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Bacteria can adapt to B-lactam stress by increasing copy number of "wimpy" B-lactamases to overcome new drugs/B-lactamase inhibitors without new evolution, threatening the B-lactam dominated antibiotic pipeline. Congrats Jake Choby (UNC) and team! nature.com/articles/s41467-0…
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I encourage students and postdocs to check out Jake Choby's new lab at UNC - he's a rockstar, outstanding mentor, and is exploring a new frontier in the fight against superbugs!
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Get your proposal together for BWF PATH's 2026 awards! Letter of Intent deadline is July 17, 2025
BWFUND@BWFUND
5 Jun 2025
Now open - LOIs for the Investigators in the Pathogenesis of Infectious Disease (PATH) program. Deadline is July 17 @ 3pm ET. More information here: buff.ly/iSu3v60 #bwfpath #GrantOpportunity
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Very cool. Congrats, @SophieHelaine!
Cell Host & Microbe@cellhostmicrobe
2 Dec 2024
Salmonella RemAIN(s) @SophieHelaine reveals prophage-encoded anti-phage defense element, RemAIN, that blocks lytic cycles of co-residing prophages. This prophage competition occurs and influences intramacrophage Salmonella persistence cell.com/cell-host-microbe/a…
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Bactericidal antibiotics release DNA that activates TLR9, while static antibiotics do not. Can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics? Amazing work by Julia Gross and collaboration with Iain Fraser! nature.com/articles/s41467-0…
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Big thank you to @TrendsMicrobiol, @FlorentMorio, @NicolasPapon49 and Anais Herivaux for highlighting our recent story on undetected heteroresistance causing failure of antifungal prophylaxis. @tmhohl71 @BingZhai @cliao345 Joao Xavier nature.com/articles/s41591-0…
Trends in Microbiology@TrendsMicrobiol
2 Oct 2024
Heteroresistance: a hidden cause behind antifungal prophylaxis failure dlvr.it/TDwzFh
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Thanks so much @SuperBugDoc for the opportunity to raise awareness about #heteroresistance. My pleasure to take part with you and @WRMillerLab!
Miller Lab Group@WRMillerLab
13 Sep 2024
See our conversation with @SuperBugDoc and @DWeissLab on antibiotic heteroresistance: Heteroresistance: Mechanisms, Diagnosis and Clinical Implications youtu.be/qcIcyn1bIHU?si=3-74… via @YouTube

Heteroresistance: Mechanisms, Diagnosis and Clinical Implications

Heteroresistance is a phenomenon that has been well characterized f...

youtube.com
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Thank you so much @madelinerb2 for this beautiful piece on heteroresistance! The clinical relevance of this undetected resistance phenomenon is becoming clear but many fundamental questions remain. Come and join our team and help unlock the mysteries - the Weiss Lab is hiring!
ASM
@ASMicrobiology
31 Jul 2024
Heteroresistance occurs when some bacteria in a population are susceptible to an antibiotic while others are resistant, paving the way for treatment failure. How does it develop, and how can scientists tackle this clinical conundrum? Read the article: asm.social/1ZD
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Great point!
Michal Tal, PhD@ImmunoFever
3 Dec 2023
There is a human tissue that builds itself up and breaks itself down every ~28 days using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.
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Congrats @hualiang2018 and @EricSkaar!
The Pi Lab@hualiang2018
15 Nov 2023
So happy to finally get this paper out!!
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A team of Emory School of Medicine researchers has discovered a way to reduce the incidence of multi-drug resistant bacteria in the human intestinal system. Read the full story ➡️ brnw.ch/21wEoO3 #DrugResistance

Emory team finds promising approach to treating multi-drug resistant microbes in human gut | Emory...

A team of Emory researchers has discovered a way to reduce the incidence of multi-drug resistant bacteria in the human intestinal system.

news.emory.edu
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My lab at @UChicago_Micro is hiring! We are looking for a research tech to work with us studying mechanisms of bacterial stress response and pathogenesis. Would be a great opportunity for recent college grads looking for research experience. Please spread the word! Links below
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The $100K prize is an award honoring Dr. Max D. Cooper, @EmoryPathology professor, whose historic discoveries have forever changed our understanding of the adaptive immune system. The inaugural prize will be awarded in fall '24. Nominations open Nov 1. ➡️ brnw.ch/21wDnE9

Emory announces $100,000 Max Cooper Prize in Immunology | Emory News

Emory professor Max Cooper’s historic discoveries forever changed our understanding of the adaptive immune system, fueling lifesaving advances in basic research and medicine. The annual award in his...

news.emory.edu
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