Molecular cell biology lab exploring the role of mechanical forces in epithelial homeostasis and cancer @UMCU_CMM
Utrecht, The Netherlands
Joined March 2021
- Tweets86
- Following267
- Followers679
- Likes204
Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin.
Great collaboration with the @Jschuije lab. Congrats to 1st authors @JooskeMonster & @ManzatoCaterina!
nature.com/articles/s41467-0…
Excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! cell.com/cell-reports/fullte…
In future work we hope to unravel how TRPV4 and integrins cooperate to control YAP signaling in CRC cells, and how mechanical forces intersect with other cues controlling CRC cell plasticity
Many thanks to all collaborators (including
@cperezgonzalez, @DMVlab, @vanRheenen_Lab,
@Snippertlab) and the Dutch Cancer Foundation @kwf_nl for making this work possible!
GloerichLab retweeted
The 2023 Cell Contact and Adhesion Gordon Research Conference (GRC) is coming up next June. This has been the premier meeting at the intersection of cell adhesion, mechanobiology, cell signaling, and their relevance to development and disease.
GloerichLab retweeted
Gloerich/Huveneers labs retreat
Having fun and discussing new epithelial and endothelial mechano-science!
GloerichLab retweeted
Are you curious? Do you want to explore the unknown? Do you want to delve into our origins? Are you an extremophile-phile? Do you want to work in the fabulous LMB? Do you BioRXIV? Do you like scones & ride a bike? If your answers to some of these are yes, come join us @lab_baum
This Post is from an account that no longer exists. Learn more
Our paper on a mechanical G2 checkpoint is out now @CellReports, in which we describe how epithelial cells sense when to divide
cell.com/cell-reports/fullte…
Great work from @_LisaDonker and everyone that contributed from our lab @umcu_cmm and @XavierTrepat and Borghi labs!
These cell density-dependent forces are transduced to the cell cycle by mechanosensitive E-cadherin adhesions via regulation of Wee1 and downstream Cdk1, thereby controlling G2 length and timing of mitotic entry
Our review is out @CurrentBiology, in which we discuss how mechanical forces regulate the #intestine - from establishing its shape during development to maintaining its self-renewal throughout life.
sciencedirect.com/science/ar…
Great effort from @RonjaHoutekamer …
