@Snippertlab
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Cancer biology. Research lab at UMC Utrecht & Oncode Institute. More an explorer than a researcher.
Utrecht, Nederland
Joined April 2019
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Very excited to share 3D Live-Seq. Integrated live-cell imaging and single-cell DNAseq of the same tumor #organoids. We reconstruct evolving tumor genomes over multiple consecutive cell divisions to map the tempo and patterns of karyotype diversification go.nature.com/2UfgAls
Hugo Snippert retweeted
1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel
biorxiv.org/cgi/content/shor… A thread:
Hugo Snippert retweeted
New publication alert🚨🚨🚨Mechanisms that clear mutations drive field cancerization in mammary tissue is out @Nature nature.com/articles/s41586-0… Congratulations all for this great team work! 🎉
Super happy to share that our paper is published in @Nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥@vib_ccb @Onco_KULeuven @NKI_nl @vanRheenen_Lab @BenSimons_Lab
Hugo Snippert retweeted
Big milestone for our group @EMIL_DKFZ @DKFZ:
We are thrilled to be among the recipients of an ERC Starting Grant from @ERC_Research #ERCStG! In the #METABAC project, we will explore how gut #bacteria contribute to #colorectal #cancer #metastasis formation. (1/12)
Hugo Snippert retweeted
1. Delighted to present work from my time in @AndreaSottoriva's lab, now in @NatureCancer! A big effort also led by @javierfermat and Nick Trahearn.
We combined genomics + digital pathology to measure evolution in a prostate cancer (PCa) clinical trial.
nature.com/articles/s43018-0…
Hugo Snippert retweeted
How do mismatch repair-deficient (MMRd) cancers trade off the evolutionary costs and benefits of elevated mutation rates?
Delighted to share our paper on adaptive mutability in MMRd colorectal cancer (CRC) @NatureGenet
nature.com/articles/s41588-0…
Tweetorial 🧵below
Very much love this story to demonstrate that adaptability during tumor evolution can also be achieved at the DNA level by reversible DNA mutations 🔥
@jansen_marnix @UMCU_CMM @oncodeinstitute
Hypermutator cancers are defined by increased mutation rates.
But do mutation rates evolve with time during tumour growth?⏱️
In this work @NatureGenet we show that hypermutator cancers use an unexpected set of genetic gear switches to adapt mutation rates to immune selection.
Looking forward to present tomorrow morning at #FEBS2024. I’ll discuss our work on real-time single-cell signaling activities in #organoids, drug response and our latest push to advance the technologies involved @UMCU_CMM @oncodeinstitute
Very much enjoyed that we could contribute to the latest discovery of the Brummelkamp team
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Hugo Snippert retweeted
Check our our latest publication on mouse and human gastruloids in Cell Stem Cell, spearheaded by @Suz_Stelloo with help from @MayteAlVin and many others in our lab and in collaboration with labs of Boudewijn Burgering, Harm Jan Vos, Maarten Altelaar and @SonnenKatharina
Online Now! Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics dlvr.it/T6wYhx #stemcells
Hugo Snippert retweeted
The 2nd edition of OrganoidNL was a great success! We are already looking forward to next year... stay tuned!
Hugo Snippert retweeted
We are now live! Register for the 2nd OrganoidNL meeting @_amolf on April 12 🗓️.
Exciting talks with opening @HansClevers, keynote Margherita Turco, and talks from @JeroenPasterk @ColindaScheele, Rob Coppes and Quiwei Pan.
amolf.nl/organoidnl-symposiu…
Extremely honoured to receive the ERC Consolidator this year #ERCCoG. Looking forward to the next 5 years of exciting science to unravel the intricacies how tumors become malignant. #CancerPrevention @UMCU_CMM @oncodeinstitute
We are proud to announce that Oncode Investigators @rschneiderlab (@ErasmusMC), @jeroen_deridder & @Snippertlab (both @UMCUtrecht) will receive the @ERC_Research Consolidator Grant! Read more:
oncodeinstitute.nl/news/onco…
Hugo Snippert retweeted
Our lastest study "Targeted Perturbation of Signaling-Driven Condensates" is now live on Molecular Cell. We've used small peptides to specificaly disrupt β-catenin condensates, resulting in decreased transcription and inhibition of cancer cell proliferation. 🔬💡 📖 Read more:
Hugo Snippert retweeted
Is #cancer drug resistance heritable or plastic? Genetic or non-genetic? How do we tell those apart? We just begun measuring the temporal dynamics of evolving cancers using controllable patient-derived #organoids. We need more experiments+theory! biorxiv.org/content/10.1101/…
Walking on my way to EMBL cancer genome conference #EMBLCanGen
Excited to present our newest work on early-stage colon cancer later today
Hugo Snippert retweeted
Are you looking to keep up to date with the rapidly progressing area of cancer genomics? 🤔 Then join us for #EMBLCanGen! ➡️ s.embl.org/can23-01
Submit your abstract by 23 Aug to be a part of this interdisciplinary community of cancer researchers 🥼
#cancerresearch #cancergenomics #molecularmedicine #systemsbiology
We welcome Sjors Middelkamp as our newest postdoc. He got off to a great start this week, being immediately awarded the NWO talent grant ‘Veni’ to continue his research on single-cell genome sequencing that he developed in the @BoxtelLab.
@UMCU_CMM @NWOFunding @oncodeinstitute
NWO has awarded Veni funding of up to EUR 280,000 to 188 promising researchers from the full breadth of science. This will allow the laureates to further develop their own research ideas over the next three years.
nwo.nl/en/news/veni-grant-fo…
Hugo Snippert retweeted
Very proud to see our work on the pan-cancer comparison of the genomic landscapes of primary and metastatic tumor published in this weeks issue of Nature: nature.com/articles/s41586-0…. @fran_mj88 @arne_van_hoeck @HartwigMedical @UMCU_CMM @oncodeinstitute @VHIO
Hugo Snippert retweeted
I am super happy to share the first work of the lab on #gastruloids. All started with @MariettaLHartl that was extremely brave to start a new project on early development. bit.ly/3ocuTqj With @SimonSuppinger they showed mechanisms of gastruloid development
Now out in @CellStemCell: researchers in the lab of @priscaliberali mapped the development of 3D clusters of cells that mimic aspects of early embryonic stages, providing insights into how complex patterns emerge from a homogeneous population of cells.
Honoured to be one of the Ammodo Science Award 2023 recipients. Award ceremony in Amsterdam @Stedelijk Museum for modern art was great, including dance performance and drinks in the foyer. Thanks to all current and past team members and colleagues @UMCU_CMM @oncodeinstitute
