Giunta Lab of Genome Evolution @ University of Rome Sapienza. We study human centromeres' tug-of-war between fast evolution & essential function. AIRC funded.
University of Rome Sapienza
Joined December 2020
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Giunta Lab on the go ➡️ heading to our first long-due lab retreat in 5 years from the start --- Excited! 😊
Giunta Lab retweeted
What is the molecular basis for maintaining centromere size and position? In a great collaboration with @NAltemose @GiuntaLab and @FachinettiLab labs, we investigate the long standing question of how heterochromatin maintains centromere size/position! biorxiv.org/content/10.1101/…
Giunta Lab retweeted
I am starting a new video series called WAY COOL GENOMICS! Join me as I showcase examples where genomics is used in a study that is important, impactful, – and just plain WAY COOL!
Giunta Lab retweeted
ERC-funded positions now open❗️❕❗️
Join the @GiuntaLab to understand human DNA evolution through the study of satellite repeats 🧬🧫🔬
APPLY here:
euraxess.ec.europa.eu/jobs/2…
Pls RT 🔄🗨️🙏
Giunta Lab retweeted
Dear community, we are very happy to announce the next Giin webinar!! Don't miss it on Tuesday, April 9th, from 5PM Rome (11AM NYC), with Stephen Jackson @SPJacksonGroup and Simona Giunta @Simona_Giunta. Zoom link: uniroma1.zoom.us/j/951499844…
Thanks @Frances87274236 Here are 10 more awesome women in STEM:
@LabBallarino @yamashitaflylab @LugerLab @promiselcooper @khmiga @GrammaticoPaola @MaikoKitaoka @PasqualGiulia @neuroluci @TeresaDavoli3 pick it up and keep it moving!
Thanks @Ivarssonlab . Here are 10 more awesome women in STEM: @NatalieKrahmer @maria_tanzer @GiuntaLab @signor_database @ChiaraFrancavi2 @charo_robles1 @chiara_dimalta @FrancesCryoEM @FrancescaNazio @CianfVale pick it up and keep it moving!
Giunta Lab retweeted
We have been needing this for a long time now. Thank you and congratulations @Simona_Giunta and team.
🧬Complete Human Diploid Genome Alert❗️
So proud to share our first work as @GiuntaLab now on bioRvix - a monumental feat for a single lab assembling T2T RPE1 as a new reference to achieve epigenetic precision:
It's not just the length but how you use it!😊biorxiv.org/content/10.1101/…
Giunta Lab retweeted
The complete human diploid reference genome of RPE-1 identifies the phased epigenetic landscapes from multi-omics data dlvr.it/SyM3sx
LINK: biorxiv.org/content/10.1101/…
For early access to the complete RPE-1 assembly and any other enquiry, please contact us: sites.google.com/uniroma1.it…
Giunta Lab retweeted
Chromosoma welcomes our newest Editor @Simona_Giunta at Uni-Rome/Sapienza. simonagiunta.site.uniroma1.i… Simona brings deep centromere expertise with true Roman flair! Welcome Simona! -EIC
What have we been doing since starting the lab in 2021? Assembling human genomes & studying their centromeres at basepair resolution. A new era of epigenomic is here! Check out our first work on preprint, constructive feedback wlecome 🧬🧫❣️NB.This work is supported by @AIRC_it
🧬Complete Human Diploid Genome Alert❗️
So proud to share our first work as @GiuntaLab now on bioRvix - a monumental feat for a single lab assembling T2T RPE1 as a new reference to achieve epigenetic precision:
It's not just the length but how you use it!😊biorxiv.org/content/10.1101/…
@Simona_Giunta sharing with the scientific community the new word she invented "isogenomic" and showing why that's important. Thanks to @nanopore for a fantastic #NanoporeConf - more great things to come, watch this space! 🧬🧫🤗
Thank you Ange + @nanopore for a fantastic #NanoporeConf - great for our lab to be invited + hearing @Simona_Giunta share with the scientific community the new word she invented "isogenomic" and showing why that's important 🧬❤️🧫 #LondonCalling2023
We brought together our data with those from too many labs to tag, and we propose the LAYERED LOOPING MODEL of #centromere #DNA organization to favor CENP-A positioning toward the kinetochore-microtubule binding interface. We are excited to showcase this & welcome feedback!🧵4/4
We found that the ring-like organization of alpha-satellite DNA at the mitotic centromere is present also under tension, even past metaphase. Pavan in @HironoriFunabi1 Lab showed CENP-A follows a similar organization by #ExM molbiolcell.org/doi/10.1091/…🧵3/4
PhD Student Elena Di Tommaso recapitulated @Simona_Giunta earlier data in two SIM platforms, OMX and Elyra @IIT showing that CenCOFISH (bio-protocol.org/en/bpdetail…) is an optimal method for #superresolution imaging of DNA avoiding effects of high temperature denaturation 🧵2/4
2015: @Simona_Giunta first imaged human centromere DNA after CenCOFISH in @HironoriFunabi1 Lab @RockefellerUni
2018-21: Presented at conferences the peculiar centromere ring structures
2021-23: Elena in the @GiuntaLab finally made the project blossom molbiolcell.org/doi/10.1091/…🧵1/4
Giunta Lab retweeted
Excited to share our recent work on KaryoCreate, a new method to engineer chromosome-specific gains and losses in human cells with @SteSantaguida and @GiuntaLab cell.com/cell/pdf/S0092-8674… Check out also recent similar and complementary work by @LensSusanne and @McClellandLab!