@GantierLab

Prof Michael Gantier's lab @Hudson_Research studies the immunology of nucleic acids (such as mRNA therapeutics)

 Australia
Joined May 2021
  • Tweets90
  • Following131
  • Followers129
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Into nucleic acid immunity? 🌏 Join #NAIS2026 in Nara, Japan! 📅 Sept 16–18, 2026 🧬 Abstract deadline (extended): June 30 📝 Register by: July 31 Explore the latest in nucleic acid immunity & connect with global experts. 🔗 ifrec.osaka-u.ac.jp/nais26/i…
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Ever wondered what happens to oligonucleotide therapeutics once they start to break down? In our new bioRxiv preprint, we provide a molecular dissection of how chemically modified 3‑base oligonucleotide fragments engage TLR7 and TLR8. Check it out! doi.org/10.64898/2026.04.29.…
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Researchers led by Drs. Michael Gantier (@GantierLab), Toshiyuki Shimizu, and Ben Corry (@CorryLab) show that modified #RNA from our own cells naturally blocks TLR7 and TLR8, preventing harmful immune activation. 📖: go.nature.com/4azVWjp 🔊: bit.ly/40muGA2
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labonline.com.au/content/lif…
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Recognition of RNA fragments by TLR7 and TLR8 helps to initiate the innate immune response. This work redefines TLR7 and TLR8 sensing by introducing 2′-OMe guanosine as a natural immune checkpoint for their activation. @NatImmunol 🔗 go.nature.com/4azVWjp
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Gantier Lab retweeted
Corry Lab@CorryLabFeb 10
How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with @GantierLab shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ nature.com/articles/s41590-0…

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

Nature Immunology - Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and...

nature.com
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I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > nature.com/articles/s41590-0…

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

Nature Immunology - Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and...

nature.com
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IsomiR stoichiometry changes as disease biomarkers. dlvr.it/TLDYyK #MTNA

IsomiR stoichiometry changes as disease biomarkers

Gantier and colleagues demonstrate, through analysis of small RNA sequencing data, that quantification of microRNA isoforms enables identification of accurate biomarker candidates overlooked in...

cell.com
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Excited to share our latest work on how microRNA length variants can be leveraged as disease biomarkers. Congratulations to Alex McAllan for all her work on this! cell.com/molecular-therapy-f…

IsomiR stoichiometry changes as disease biomarkers

Gantier and colleagues demonstrate, through analysis of small RNA sequencing data, that quantification of microRNA isoforms enables identification of accurate biomarker candidates overlooked in...

cell.com
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For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at rnavic.com/

RNA Victoria minisymposium | RNA Victoria Network

rnavic.com
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Follow us on gantierlab.bsky.social
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Please mark your calendars for the next RNAVIc symposium. It will be July 22nd at WEHI Davis Auditorium starting at 2pm. rnavic.com/

RNA Victoria minisymposium | RNA Victoria Network

rnavic.com
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We are thrilled to announce the official launch of the #RNAte Platform at @Hudson_Research, delivering huge advances in the development of #mRNA-based therapies. 🥳💪🏽 Read more about this revolutionary platform: bit.ly/3SEEl23 @VicGovAu @VicGov_DJSIR
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We recently welcomed Deputy Premier & Minister for Medical Research, The Hon @BenCarrollMP to Hudson Institute! 🙌 Minister Carroll went behind the scenes with some of our researchers, including our CEO & Director Prof Elizabeth Hartland, to learn more about our research.🔬
Deputy Premier & Minister for Medical Research, The Hon Ben Carroll and Hudson Institute CEO & Director Professor Elizabeth Hartland

ALT Deputy Premier & Minister for Medical Research, The Hon Ben Carroll and Hudson Institute CEO & Director Professor Elizabeth Hartland

Deputy Premier & Minister for Medical Research, The Hon Ben Carroll speaks with researchers at Hudson Institute

ALT Deputy Premier & Minister for Medical Research, The Hon Ben Carroll speaks with researchers at Hudson Institute

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Replying to @Hudson_Research @CiiiD_Hudson
Thrilled to be joining longtime friends and colleagues @CiiiD_Hudson including those I could find on twitter @ProfHartland @FerreroMicro @Tate_Lab @GantierLab @pjhpauljh @Forster_Lab @PhilBardin
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Gantier Lab retweeted
Labo Pépin@Labo_Pepin22 Nov 2023
Exciting data to build our research program on thromboinflammation! So proud of this first research paper! Thanks to the many students and collaborators who contribute to this story! life-science-alliance.org/co…

Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation

Platelets display unexpected roles in immune and coagulation responses. Emerging evidence suggests that STING is implicated in hypercoagulation. STING is an adaptor protein downstream of the DNA...

life-science-alliance.org
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Our latest work, out today in @PLOSBiology suggests that not only do mammalian cells absorb bacteriophages, but they appear to use them as a resource to enhance growth! journals.plos.org/plosbiolog… This work was led by @marion_bichet and out on World Phage Week! #WorldPhageWeek

Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth...

There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses; this study shows that mammalian cells...

journals.plos.org
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(2/2) Talks from: @ShaliniChelliah (@elaine_sanij lab, @SVIResearch), @QiZhang85 (@MonashBDI), @eric_kusnadi (@PeterMacCC), Steve Rockman (@CSL) and Cameron Stuart (@CSIRO). @traude_beilharz @GantierLab @ClarksysCorner @nadia_davidson @jacki_hf @EMBLAustralia
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RNA Victoria meeting: Dec 5, 2023, at @MonashUni. Program & FREE registration: rnavic.com 🙏RT! #RNAvic

RNA Victoria minisymposium | RNA Victoria Network

rnavic.com
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Noxopharm’s Dr Olivier Laczka and Associate Professor Michael Gantier from @Hudson_Research are currently showcasing the team’s latest breakthroughs at the Oligonucleotide Therapeutics Society Annual Meeting in Barcelona. #biotech #Innovation #mRNA
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