Excited to share work by Emily Wang & Zhouyu Zhang, in a collab with PKU: Martini 3 CG sims overestimate lipid scrambling, predict it in proteins that don't, and give anomalous binding, from low headgroup polarity. But small parameter refinements fix it. tinyurl.com/m3scramble

Kudos to @ciara__wallis & @yiechanglin for their elegant publication testing #AlphaFold for predicting protein oligomeric states including advice on when it is likely to do well and when it can fail. 🌟🎉🌟🎉 #StructuralBiology #AI #Biophysics tiny.cc/oligos

Excited to share this paper from @yiechanglin showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bpj.2026.0…

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with @GantierLab shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ nature.com/articles/s41590-0…

Beginning 2026 with a flipping good paper🚀OSCA/TMEM63 proteins do double duty: they’re ion channels andmechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏@yiechanglin @Charles_D_Cox doi.org/10.1038/s41467-026-6…

Great to see this paper with @whoiselainetao out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated ion channel superfamily members #ionchannel #AI #StructuralBiology sciencedirect.com/science/ar…

2 yrs ago @yiechanglin sent me this of lipid scrambling by OSCA1.2. Now we show it’s common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @Charles_D_Cox &Zhang lab. tiny.cc/tmem63

Applications for this position close tomorrow. Don't miss out!

🌟We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids🌟 Join us at @ourANU with amazing collaborators and great working conditions! Apply: tiny.cc/corry. Us: karri.anu.edu.au

Also bittersweet to announce the final work of @whoiselainetao in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members 🤩 we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao 🎩 tiny.cc/VSD-AF2

Bittersweet to announce YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin 🤩

Thrilled to share our latest preprint from @yiechanglin & @ciara__wallis showing AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀) tiny.cc/oligomers

Big congratulations to the very sharp @whoiselainetao who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @ourANU @scienceANU 🔪🎆👩‍🔬👩‍🎓

Big congratulations to @Riottowow for winning an Anders Early Career Award at @LorneProteins #lorneproteins2025 ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel.

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection/permeation by a channel-like knock-kiss-kick mechanism 💻 @ciara__wallis @Riottowow tiny.cc/xpr1

Excited to start the year with this lovely paper with @whoiselainetao showing that drugs that inhibit sodium channels bind in a range of sites within the pore cavity rather having a single distinct pose. @JGenPhysiol @scienceANU @NCInews