@FowlerLab

Laboratory for Cellular Architecture | Studying how actin dynamics builds cell and tissue structures in health and disease | The Scripps Research Institute

 La Jolla, San Diego
scripps.edu/fowler
Joined March 2018
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  • Following18
  • Followers69
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Just uploaded my first post with @preLights ! Read to learn more about an awesome system developed by @AshToye_Bristol and @thebaumlab to study malaria parasite invasion. prelights.biologists.com/hig…

Stable knockout and complementation of receptor expression using in vitro cell line derived...

CRISPR meets red blood cells – a new model system to illuminate the roles of host proteins in malaria parasite invasion

prelights.biologists.com
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#UltimaThule or enculeating erythroblast? You decide. Phone and confocal data courtesy of @RBNowak74
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How changing labs after grad school revealed a catalytic function for an eye lens protein long thought to be chemically inert @jbiolchem bit.ly/2BBRZLU via @asbmb @EurekAlert
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Our review article on the regulation of actin dynamics by tropomodulin 3 is now published! link.springer.com/article/10…
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Fowler Lab retweeted
Science Friday@scifri5 Oct 2018
Today at 2pm ET: For the first time ever, two female scientists won the #NobelPrize for both physics and chemistry. We'll be chatting with one of the recipients @francesarnold on #SciFriLive! scifri.me/os1
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Congratulations to Frances Arnold, George Smith, and Gregory Winter, whose Nobel-winning achievements have enabled such exciting science. Read some of their papers in JBC: bit.ly/2NgCNGw
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ARP2/3 COMPLEX IN ACTION Arp2/3 creates networks of branched actin filaments, and plays roles in endocytosis, membrane trafficking, cell motility, etc. But do not be fooled by the vast literature. We are only scratching the surface of how Arp2/3 functions in cells. #CellBiology
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Check out this very cheap TIRF scope! The site also has posts about other inexpensive/DIY lab equipment.
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SO MUCH EFFORT ..... SO LITTLE PROGRESS Are you working a lot and not getting anywhere? This epithelial cell knows how you feel. #CellBiology
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Our work on myosin in red blood cells was recently featured in @TheScientistLLC ! the-scientist.com/the-litera… Check out the original paper in @PNASNews here pnas.org/content/early/2018/…
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Read Justin and Velia's review to learn everything you need to know about Tmod3!
Justin Parreno@ParrenoJustin5 Sep 2018
My preprint has been published today in @PeerJPreprints peerj.com/preprints/27172 #Biochemistry #CellBiology #MolecularBiology

Multifunctional roles of Tropomodulin-3 in regulating actin dynamics

Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with...

peerj.com
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Happy Wednesday from the newest members of the Fowler lab - the giant podocyte, platelet, and red blood cells! Starting with the podocyte: 1,000,000x, 5,000,000x, 1,250,000x, and 750,000x actual size.
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Today marks the end of summer intern season in the Fowler lab! We hosted two high school students and one undergrad who made significant progress in our RBC myosin and lens tropomyosin projects. Thanks @hightechhigh @ScrippsRTI and @SD_LSSI for making these internships possible.
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Nominate your favorite female microscopists! There are only two in San Diego so far.
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We're looking for a postdoc synthetic/medicinal chemist to work with Jeff Kelly @scrippsresearch on hit-to-lead development of stabilizers of amyloid precursor proteins. Would suit a new PhD. Immediate start. Good facilities and resources, great weather. DM me. #chemjobs
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CANCER ON THE MOVE A #melanoma cell crawling in a culture dish sitting on a spinning disk confocal microscope. #CellBiology #cancer #cancerresearch
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Check out @ParrenoJustin 's paper on mechanical strain in the mouse eye lens in @MBoCjournal published online this week! Authors include Cathy Cheng and @RBNowak74 molbiolcell.org/doi/full/10.…
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Yes! The human eye can detect so much more information from grayscale images. xitter.cf/MAG2ART/status/1021412…
Dylan Burnette
@MAG2ART23 Jul 2018
DISPLAY DATA IN GRAYSCALE Don't get me wrong, I do love color overlays of microscopy #data. However, try to show each grayscale channel when possible (especially in figures). When it comes to data, more is more. Movie: crawling #cancer cell #CellBiology
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It's great to see so much recognition of wonderful female cell biologists at all career stages by @ASCBiology Congratulations to all the award winners! xitter.cf/DavidGDrubin/status/10…
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