
Biomolecular designer; currently postdoc @UWproteindesign; starting my lab @ISTAustria in March 2024 @flopraetorius.bsky.social
Seattle
Joined January 2023
- Tweets106
- Following203
- Followers688
- Likes288
Florian Praetorius retweeted
Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!
New research in Science represents a notable step forward in designing enzymes from scratch.
With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins.
Learn more: scim.ag/4hU7O1H
Florian Praetorius retweeted
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases.
I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known.
People can contact me directly at my first name (as written in my profile) at octant.bio.
Florian Praetorius retweeted
“Science is a human activity.”
The week before chemistry laureate David Baker visited Stockholm to receive his Nobel Prize, his 101st PhD student had just graduated from his lab. For Baker, doing great science is about collaboration – he puts great effort into fostering a diverse, vibrant and sociable community of scientists that he works with. One hundred and thirty of those students and researchers joined him in Stockholm – perhaps the ultimate lab celebration!
More about Baker and the 2024 Nobel Prize in Chemistry: bit.ly/4iz7B56
Florian Praetorius retweeted
After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton @hendrik_dietz
biorxiv.org/content/10.1101/…
Florian Praetorius retweeted
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…
Florian Praetorius retweeted
Finally, out in @ScienceMagazine today, our work on de novo protein design. Together with @HattoriLab , @sokrypton & @hendrik_dietz we showed how we can drastically improve AF2 based hallucination, surpassing, or reaching SOTA diffusion models
doi.org/10.1126/science.adq1…
Florian Praetorius retweeted
So delighted to have this finally online!
In our newest preprint we are detailing the computational design of a catalytically active helical barrel protein with a highly engineerable central channel. Check it out!
biorxiv.org/content/10.1101/…
Florian Praetorius retweeted
Excited to join the Gene Center at LMU @GeneCenter_LMU @LMU_Muenchen as a professor, looking forward to design some cool and unusual de novo proteins here!
🥳 We welcome Lukas Milles as new group leader🤗🤗!
Since July 2024, he's leading an Emmy Noether Research Group at MPI Biochemistry, now also affiliated with us! 💻🧪 His work focuses on protein design, deep learning & biophysics. genzentrum.uni-muenchen.de/r…
@LFMilles @MPI_Biochem
Florian Praetorius retweeted
I am looking for a partner in crime who actually understands biology in Vienna — join Aithyra to make some magic
oeaw.ac.at/aithyra/news/sear…
Florian Praetorius retweeted
#MERS vaccines built on our two-component protein nanoparticle platform induce robust neutralizing antibody responses and protect mice against vaccine-matched challenge.
This collaborative project was led by @chao_cara and is out now on @biorxivpreprint: biorxiv.org/content/10.1101/…
Florian Praetorius retweeted
Three @ISTAustria scientists have won @erc_research Starting Grants #ERCStG! A combined 4.8 million euros will go to @MMondelli, @aliciakmichael, and @lisa_Bugnet. Read more about the scientists and their projects 🔗 bit.ly/3XvfQXo
Florian Praetorius retweeted
Passionate about AI + Proteins? We are hiring deep-learning scientists at all levels. We are in a privileged location with extensive resources. Junior or senior, if this resonates with you, apply now!
recruitment.crg.eu/content/j…
Florian Praetorius retweeted
Our nanopore design paper is now published! We developed computational methods to design de novo pores with custom size, conductance and shape. We hope the technology will advance a range of sensing applications. @structbiolbxl @VIBLifeSciences @_VIB_AI science.org/doi/10.1126/scie…
Florian Praetorius retweeted
Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6
nature.com/articles/s41586-0…
Florian Praetorius retweeted
Our work validating designed membrane b-barrels in silico is published! It started as Elixir #3DBioinfo meeting discussion (I generated models instead of preparing my talk), then a fun exchange with @sokrypton. Thanks to all! @structbiolbxl @ELIXIRnodeBE onlinelibrary.wiley.com/doi/…
Florian Praetorius retweeted
Now online: We developed novel oligomers and turned them into FGFR agonists via binder induced receptor clustering. #denovo_proteins sciencedirect.com/science/ar…
Florian Praetorius retweeted
My group at @ISTAustria is recruiting a lab manager/research technician to join when we start in July! If you're passionate about science and thrive in a dynamic environment, apply here: ista.ac.at/en/job/?title=Res… #ResearchJobs #LabManagement #ScienceCareers
Florian Praetorius retweeted
My first paper at @OxfordChemistry is out in @NaturePhotonics: Single-protein optical holography! Big thanks to Emanuel Pfitzner and Philipp Kukura. We improved the sensitivity of optical holography by orders of magnitude to detect single proteins. 1/5 nature.com/articles/s41566-0…
Florian Praetorius retweeted
The Haselbach Lab is on the hunt for passionate PhD student to explore the mysteries of the ubiquitin proteasome system within gametes through cryoET, or dive into the dynamic world of E3 Ligases using time-resolved cryo-EM. Apply by April 15th.
Check out the Biochemistry, Biophysics and Structural groups that are offering fully funded positions in this call - we have 30 openings. Pass on or share with your colleagues!
ow.ly/UZAg50QJUer
@IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs @univienna @MedUni_Wien
Florian Praetorius retweeted
Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠
nature.com/articles/s41589-0…
Special thanks to @eaandrzejewska , Danny Sahtoe and David Baker


























