@KingLabIPD

News from the King Lab @UW. Part of @UWproteindesign and @UWBiochemistry. Some assembly required.

 Seattle, WA
kinglab.ipd.uw.edu
Joined June 2018
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most protein design focuses on using the 20 amino acids for protein function. in biology, post-translational modifications such as glycosylations are essential to function. we program protein function through glycosylation👇
King Lab
@KingLabIPDOct 9
🚨 pre-print alert 🚨 Glycosylation has remained outside the reach of biomolecular design, but with new all-atom methods we are now able to control the types of glycans displayed on our de novo proteins. In our newest @biorxivpreprint, we present multiple structurally-encoded oligomannose-type glycoproteins, establishing glycans as a designable parameter! bit.ly/4s2qK4M

Programming N-linked glycan composition through de novo protein design

N-linked glycans are ubiquitous post-translational modifications that mediate diverse biological processes, including cell signaling and adhesion, molecular recognition, and host-pathogen interacti...

biorxiv.org
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🚨 pre-print alert 🚨 Glycosylation has remained outside the reach of biomolecular design, but with new all-atom methods we are now able to control the types of glycans displayed on our de novo proteins. In our newest @biorxivpreprint, we present multiple structurally-encoded oligomannose-type glycoproteins, establishing glycans as a designable parameter! bit.ly/4s2qK4M

Programming N-linked glycan composition through de novo protein design

N-linked glycans are ubiquitous post-translational modifications that mediate diverse biological processes, including cell signaling and adhesion, molecular recognition, and host-pathogen interacti...

biorxiv.org
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These glycoproteins engage immune lectins and pathogenic bacterial adhesins through their #glycans, showing that we can now design functional glycoproteins.
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🚨 new paper alert 🚨 Here we apply our protein nanoparticle vaccine platform toward a bacterial indication: uropathogenic E. coli, the primary causative agent of UTIs: bit.ly/4waDqaM

Frontiers | Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanopa...

Urinary tract infections, caused primarily by uropathogenic E. coli, are a significant public health burden, affecting approximately 50% of women worldwide. ...

frontiersin.org
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Last week, Grace Hendricks successfully defended her dissertation and earned her PhD!
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Excited to share our new preprint: “Computational design of membrane fusion proteins” Huge thanks to all collaborators, co-authors, @KingLabIPD, and everyone at @UWproteindesign who contributed to this work. Preprint: biorxiv.org/content/10.64898…
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.@KingLabIPD ski on a beautiful spring day at Crystal! I love my coworkers 💜💛 – at Seattle, WA
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A team presents vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. @KingLabIPD @anniedosey @UWBiochemistry scim.ag/4reeKei
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🚨 new paper alert 🚨 Here we demonstrate increased anti-RBS neutralizing responses elicited by stabilized influenza H5 immunogens: bit.ly/4u8UxJl
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Happy New Year! We are delighted to share with you our newest @biorxivpreprint, in which we describe the de novo design of protein nanoparticles with structures tailored to specific applications. Long a dream, it is now reality! biorxiv.org/content/10.64898…

De novo design of protein nanoparticles with integrated functional motifs

Computational design of self-assembling proteins has long relied on pre-existing structures and sequences, fundamentally limiting control over their structural and functional properties. Recent...

biorxiv.org
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Yesterday Dane Zambrano successfully defended her thesis on hybrid lipid-protein nanoparticles! Excellent work Dr. Dane!!
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🚨new paper alert🚨 Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks. Read more @PNASNews: doi.org/10.1073/pnas.2409566…
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🚨 new paper in @ScienceTM 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.

Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody...

Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.

science.org
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You can also learn more at our @UWproteindesign blog post: bit.ly/3KKnObo.
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mRNA vaccines 🤝 designed nanoparticle immunogens
Science Translational Medicine@ScienceTM15 Oct 2025
This week's issue of #ScienceTranslationalMedicine has arrived! New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. scim.ag/43lkZUm
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Couldn't have asked for a lovelier day to break ground in our new lab downtown!🌞
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Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!
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🚨 New paper alert! 🚨 Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM
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🚨 new paper alert 🚨 We present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances! This project was led by Dr. Sanela Rankovic is out now in Nature Materials: tinyurl.com/yj8t476d
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You can also learn more in the most recent @UWproteindesign blog post: ipd.uw.edu/2025/08/creating-…

Creating multi-protein systems with atomic precision – Institute for Protein Design

Protein design is expanding from building single molecules to generating entire systems from scratch with parts that work together in ways nature never explored.

ipd.uw.edu
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